The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness

RON is a member of the receptor tyrosine kinase gene family that includes the MET oncogene, whose germline mutations have been causally related to human tumorigenesis. In vitro, RON and MET receptors cross-talk, synergize in intracellular signaling, and cooperate in inducing morphogenic responses. H...

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Veröffentlicht in:	Experimental cell research 2003-08, Vol.288 (2), p.382-389
Hauptverfasser:	Maggiora, Piera, Lorenzato, Annalisa, Fracchioli, Stefano, Costa, Barbara, Castagnaro, Massimo, Arisio, Riccardo, Katsaros, Dionyssios, Massobrio, Marco, Comoglio, Paolo M, Flavia Di Renzo, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Female Hepatocyte growth factor Hepatocyte Growth Factor - metabolism Hepatocyte growth factor receptor Human ovary Humans Ligands Macrophage stimulating protein MET oncogene Middle Aged Oncogenes Ovarian neoplasm Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Receptor tyrosine kinase RON gene Tumor Cells, Cultured
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