Low density lipoprotein receptor deficiency in cultured hepatocytes of the WHHL rabbit. Further evidence of two pathways for catabolism of exogenous proteins

We have studied hepatocytes cultured from Watanabe-heritable hyperlipidemic (WHHL) rabbits, animals that display striking elevation of plasma low density lipoprotein (LDL), spontaneous atherosclerosis, and an absence of LDL receptor activity in cultured fibroblasts. Degradation of LDL by WHHL hepato...

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Veröffentlicht in:	The Journal of biological chemistry 1981-10, Vol.256 (19), p.9789-9792
Hauptverfasser:	Attie, A D, Pittman, R C, Watanabe, Y, Steinberg, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Chloroquine - pharmacology Colchicine - pharmacology Female Hydroxymethylglutaryl CoA Reductases - metabolism Hyperlipidemias - genetics Hyperlipidemias - metabolism Kinetics Lipoproteins, LDL - metabolism Lipoproteins, LDL - pharmacology Liver - drug effects Liver - metabolism Rabbits Receptors, Cell Surface - metabolism Receptors, LDL
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