Multidrug resistance proteins and topoisomerase IIalpha expression in colon cancer: association with metastatic potential
To investigate the role of multidrug resistance proteins and topoisomerase IIalpha in colon cancer. Tissue sections from 89 Dukes' stage B-D colon cancer patients were selected. The expression of multidrug resistance proteins and topoisomerase IIalpha in primary tumour cells was assessed by sta...
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| Veröffentlicht in: | Pathology 2003-08, Vol.35 (4), p.315-318 |
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| creator | Zorzos, Haralampos S Lazaris, Andreas C Korkolopoulou, Penelope A Kavantzas, Nikolaos G Tseleni-Balafouta, Sofia Patsouris, Efstratios S Tsavaris, Nikolaos V Davaris, Panagiotis S |
| description | To investigate the role of multidrug resistance proteins and topoisomerase IIalpha in colon cancer.
Tissue sections from 89 Dukes' stage B-D colon cancer patients were selected. The expression of multidrug resistance proteins and topoisomerase IIalpha in primary tumour cells was assessed by standard immunohistochemistry. The extent of their expression was measured by image analysis and was correlated with clinicopathological features of the patients.
P-glycoprotein was associated with the presence of lymph node metastasis (P=0.005), vessel invasion (P=0.0001) and perineural invasion (P=0.020).
P-glycoprotein is probably involved in the processes of local invasion and metastatic dissemination. |
| format | Article |
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Tissue sections from 89 Dukes' stage B-D colon cancer patients were selected. The expression of multidrug resistance proteins and topoisomerase IIalpha in primary tumour cells was assessed by standard immunohistochemistry. The extent of their expression was measured by image analysis and was correlated with clinicopathological features of the patients.
P-glycoprotein was associated with the presence of lymph node metastasis (P=0.005), vessel invasion (P=0.0001) and perineural invasion (P=0.020).
P-glycoprotein is probably involved in the processes of local invasion and metastatic dissemination.</description><identifier>ISSN: 0031-3025</identifier><identifier>PMID: 12959767</identifier><language>eng</language><publisher>England</publisher><subject>Adenocarcinoma - metabolism ; Adenocarcinoma - secondary ; Adenoma - metabolism ; Adenoma - pathology ; Adult ; Aged ; Antigens, Neoplasm ; ATP Binding Cassette Transporter, Subfamily B - metabolism ; Biomarkers, Tumor ; Colonic Neoplasms - metabolism ; Colonic Neoplasms - pathology ; DNA Topoisomerases, Type II - metabolism ; DNA-Binding Proteins ; Drug Resistance, Multiple - physiology ; Female ; Humans ; Immunoenzyme Techniques ; Lymph Nodes - metabolism ; Lymph Nodes - pathology ; Lymphatic Metastasis - physiopathology ; Male ; Middle Aged ; Multidrug Resistance-Associated Proteins - metabolism ; Neoplasm Invasiveness</subject><ispartof>Pathology, 2003-08, Vol.35 (4), p.315-318</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12959767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zorzos, Haralampos S</creatorcontrib><creatorcontrib>Lazaris, Andreas C</creatorcontrib><creatorcontrib>Korkolopoulou, Penelope A</creatorcontrib><creatorcontrib>Kavantzas, Nikolaos G</creatorcontrib><creatorcontrib>Tseleni-Balafouta, Sofia</creatorcontrib><creatorcontrib>Patsouris, Efstratios S</creatorcontrib><creatorcontrib>Tsavaris, Nikolaos V</creatorcontrib><creatorcontrib>Davaris, Panagiotis S</creatorcontrib><title>Multidrug resistance proteins and topoisomerase IIalpha expression in colon cancer: association with metastatic potential</title><title>Pathology</title><addtitle>Pathology</addtitle><description>To investigate the role of multidrug resistance proteins and topoisomerase IIalpha in colon cancer.
Tissue sections from 89 Dukes' stage B-D colon cancer patients were selected. The expression of multidrug resistance proteins and topoisomerase IIalpha in primary tumour cells was assessed by standard immunohistochemistry. The extent of their expression was measured by image analysis and was correlated with clinicopathological features of the patients.
P-glycoprotein was associated with the presence of lymph node metastasis (P=0.005), vessel invasion (P=0.0001) and perineural invasion (P=0.020).
P-glycoprotein is probably involved in the processes of local invasion and metastatic dissemination.</description><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - secondary</subject><subject>Adenoma - metabolism</subject><subject>Adenoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Antigens, Neoplasm</subject><subject>ATP Binding Cassette Transporter, Subfamily B - metabolism</subject><subject>Biomarkers, Tumor</subject><subject>Colonic Neoplasms - metabolism</subject><subject>Colonic Neoplasms - pathology</subject><subject>DNA Topoisomerases, Type II - metabolism</subject><subject>DNA-Binding Proteins</subject><subject>Drug Resistance, Multiple - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Lymph Nodes - metabolism</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multidrug Resistance-Associated Proteins - metabolism</subject><subject>Neoplasm Invasiveness</subject><issn>0031-3025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1OwzAQhH0A0VJ4BeQTt0h27MQ1N1TxU6mIS-_R1tlSI8c2tiPo25OKctrV7MwnzV6QOWOCV4LVzYxc5_zJGJPL5fKKzHitG61aNSfHt9EV26fxgybMNhfwBmlMoaD1mYLvaQkx2BwGTJCRrtfg4gEo_sQpkG3w1HpqgpsWcwqnBwo5B2OhnI7fthzogAUmdLGGxonsiwV3Qy734DLenueCbJ-ftqvXavP-sl49bqrYSFUJaIUQe65BSNZjr4AZZVrdoJESmdhJqXqotW74pAsExvcGawCUHNWuEQty_4edOn2NmEs32GzQOfAYxtwp0daaq5Px7mwcdwP2XUx2gHTs_n8lfgG6EGhr</recordid><startdate>200308</startdate><enddate>200308</enddate><creator>Zorzos, Haralampos S</creator><creator>Lazaris, Andreas C</creator><creator>Korkolopoulou, Penelope A</creator><creator>Kavantzas, Nikolaos G</creator><creator>Tseleni-Balafouta, Sofia</creator><creator>Patsouris, Efstratios S</creator><creator>Tsavaris, Nikolaos V</creator><creator>Davaris, Panagiotis S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200308</creationdate><title>Multidrug resistance proteins and topoisomerase IIalpha expression in colon cancer: association with metastatic potential</title><author>Zorzos, Haralampos S ; Lazaris, Andreas C ; Korkolopoulou, Penelope A ; Kavantzas, Nikolaos G ; Tseleni-Balafouta, Sofia ; Patsouris, Efstratios S ; Tsavaris, Nikolaos V ; Davaris, Panagiotis S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p547-3a6333f19a340ded7a0c7c695ec44e03b447da29951c7c3ea01fce2aae41e7b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - secondary</topic><topic>Adenoma - metabolism</topic><topic>Adenoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Antigens, Neoplasm</topic><topic>ATP Binding Cassette Transporter, Subfamily B - metabolism</topic><topic>Biomarkers, Tumor</topic><topic>Colonic Neoplasms - metabolism</topic><topic>Colonic Neoplasms - pathology</topic><topic>DNA Topoisomerases, Type II - metabolism</topic><topic>DNA-Binding Proteins</topic><topic>Drug Resistance, Multiple - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Lymph Nodes - metabolism</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multidrug Resistance-Associated Proteins - metabolism</topic><topic>Neoplasm Invasiveness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zorzos, Haralampos S</creatorcontrib><creatorcontrib>Lazaris, Andreas C</creatorcontrib><creatorcontrib>Korkolopoulou, Penelope A</creatorcontrib><creatorcontrib>Kavantzas, Nikolaos G</creatorcontrib><creatorcontrib>Tseleni-Balafouta, Sofia</creatorcontrib><creatorcontrib>Patsouris, Efstratios S</creatorcontrib><creatorcontrib>Tsavaris, Nikolaos V</creatorcontrib><creatorcontrib>Davaris, Panagiotis S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zorzos, Haralampos S</au><au>Lazaris, Andreas C</au><au>Korkolopoulou, Penelope A</au><au>Kavantzas, Nikolaos G</au><au>Tseleni-Balafouta, Sofia</au><au>Patsouris, Efstratios S</au><au>Tsavaris, Nikolaos V</au><au>Davaris, Panagiotis S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multidrug resistance proteins and topoisomerase IIalpha expression in colon cancer: association with metastatic potential</atitle><jtitle>Pathology</jtitle><addtitle>Pathology</addtitle><date>2003-08</date><risdate>2003</risdate><volume>35</volume><issue>4</issue><spage>315</spage><epage>318</epage><pages>315-318</pages><issn>0031-3025</issn><abstract>To investigate the role of multidrug resistance proteins and topoisomerase IIalpha in colon cancer.
Tissue sections from 89 Dukes' stage B-D colon cancer patients were selected. The expression of multidrug resistance proteins and topoisomerase IIalpha in primary tumour cells was assessed by standard immunohistochemistry. The extent of their expression was measured by image analysis and was correlated with clinicopathological features of the patients.
P-glycoprotein was associated with the presence of lymph node metastasis (P=0.005), vessel invasion (P=0.0001) and perineural invasion (P=0.020).
P-glycoprotein is probably involved in the processes of local invasion and metastatic dissemination.</abstract><cop>England</cop><pmid>12959767</pmid><tpages>4</tpages></addata></record> |
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| source | Taylor & Francis:Master (3349 titles); MEDLINE; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - metabolism Adenocarcinoma - secondary Adenoma - metabolism Adenoma - pathology Adult Aged Antigens, Neoplasm ATP Binding Cassette Transporter, Subfamily B - metabolism Biomarkers, Tumor Colonic Neoplasms - metabolism Colonic Neoplasms - pathology DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins Drug Resistance, Multiple - physiology Female Humans Immunoenzyme Techniques Lymph Nodes - metabolism Lymph Nodes - pathology Lymphatic Metastasis - physiopathology Male Middle Aged Multidrug Resistance-Associated Proteins - metabolism Neoplasm Invasiveness |
| title | Multidrug resistance proteins and topoisomerase IIalpha expression in colon cancer: association with metastatic potential |
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