Role of apoptosis-inducing factor in myocardial cell death by ischemia–reperfusion

Although apoptosis contributes to myocardial cell death in the ischemia–reperfused heart, the molecular basis of apoptosis is poorly understood. Apoptosis-inducing factor (AIF) has been characterized as a caspase-independent death effector. Upon the induction of apoptosis, mitochondrial AIF is relea...

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