Synthesis of the Antifungal Macrolide Antibiotic (+)-Roxaticin

The total synthesis of the antifungal macrolide antibiotic roxaticin has been accomplished. The synthesis relies principally on aldol and directed reduction steps to construct the extended 1,3-polyol array present in the natural product. Three principal nonpolyene containing fragments were assembled...

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Veröffentlicht in:	Journal of the American Chemical Society 2003-09, Vol.125 (36), p.10899-10905
Hauptverfasser:	Evans, David A, Connell, Brian T
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Biological and medical sciences Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Macrolides - chemical synthesis Macrolides - chemistry Medical sciences Organic chemistry Pharmacology. Drug treatments Preparations and properties Stereoisomerism Streptomyces - chemistry
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