Reversal of neuromuscular blockade and simultaneous increase in plasma Rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969

The purpose of this study was to determine the changes in the plasma concentration of rocuronium and the reversal of its neuromuscular blockade after the intravenous infusion of Org 25969, the novel neuromuscular block-reversal agent, in anesthetized guinea pigs. Rocuronium was infused for 1 h at a...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2003-09, Vol.99 (3), p.632-637
Hauptverfasser:	EPEMOLU, Ola, BOM, Anton, HOPE, Frank, MASON, Rona
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstanols - antagonists & inhibitors Androstanols - blood Androstanols - pharmacology Anesthesia Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Blood Pressure - drug effects Body Weight - physiology Chromatography, High Pressure Liquid Cyclodextrins - administration & dosage Cyclodextrins - pharmacology gamma-Cyclodextrins Guinea Pigs Heart Rate - drug effects Infusions, Intravenous Male Mass Spectrometry Medical sciences Muscle Contraction - drug effects Neuromuscular Nondepolarizing Agents - antagonists & inhibitors Neuromuscular Nondepolarizing Agents - blood Neuromuscular Nondepolarizing Agents - pharmacology Neuropharmacology Pharmaceutical Vehicles Pharmacology. Drug treatments Rocuronium Sugammadex
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