Inhibition of experimental choroidal neovascularization by an anti-growth agent inhibiting vascular endothelial development

Purpose: To determine whether FR118487, a recently developed angiogenesis inhibitor, affects experimental choroidal neovascularization (CNV) induced by laser photocoagulation in pigmented rats. Methods: Focal laser photocoagulation (argon green 50 mW, 0.04 seconds, 200 μm) was applied to the retinoc...

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Veröffentlicht in:	Japanese journal of ophthalmology 2003-09, Vol.47 (5), p.454-458
Hauptverfasser:	Matsuo, Yoko, Li, Yutao, Taniguchi, Hiroyasu, Motoda, Masanori, Amemiya, Tsugio
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis inhibitor Angiogenesis Inhibitors - pharmacology Animals Biological and medical sciences Capillaries - ultrastructure choroidal neovascularization Choroidal Neovascularization - etiology Choroidal Neovascularization - prevention & control corrosion cast Corrosion Casting Drug Administration Schedule Endothelium, Vascular - drug effects Endothelium, Vascular - growth & development Eye inhibition effect Laser Coagulation laser photocoagulation Medical sciences Microscopy, Electron, Scanning Pharmacology. Drug treatments Rats Rats, Inbred BN Spiro Compounds - administration & dosage Spiro Compounds - pharmacology
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