Reduced β-Catenin Expression in the Cytoplasm of Advanced-Stage Superficial Spreading Malignant Melanoma
Purpose: The purpose of the present work was to analyze the expression of β-catenin in a panel of superficial and nodular spreading primary and metastatic melanomas, and to correlate the level of immunohistochemical staining to clinicopathological parameters. Experimental Design: Expression of β-cat...
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| Veröffentlicht in: | Clinical cancer research 2003-08, Vol.9 (9), p.3383-3388 |
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| creator | MAELANDSMO, Gunhild M HOLM, Ruth NESLAND, Jahn M FODSTAD, Øystein FLØRENES, Vivi Ann |
| description | Purpose: The purpose of the present work was to analyze the expression of β-catenin in a panel of superficial and nodular spreading
primary and metastatic melanomas, and to correlate the level of immunohistochemical staining to clinicopathological parameters.
Experimental Design: Expression of β-catenin was examined by immunohistochemistry in 106 superficial and 58 nodular spreading primary melanomas,
as well as in 66 metastatic lesions.
Results: Membrane-associated staining was detected in nearly all of the cases, and no association to clinical parameters could be
revealed. When cytoplasmic localization of the protein was recorded, a significant higher fraction of the superficial than
the nodular spreading primary lesions expressed the protein in the majority of the cells ( P < 0.0001). Interestingly, metastatic lesions from superficial melanomas demonstrated down-regulated expression of the protein,
and in agreement with this a significant inverse correlation between protein expression and the vertical thickness of the
primary lesion was detected ( P = 0.012). Furthermore, a significant correlation between cytoplasmic localization and disease-free survival ( P = 0.0006) was revealed, but β-catenin did not have any significant impact on overall survival for this group of patients
( P = 0.0824). No association was detected between β-catenin expression and clinicopathological parameters in the nodular subgroup
of melanomas, indicating that the protein may play different roles in the malignant progression of the two main types of melanomas.
Conclusion: In summary, we hypothesize that cytoplasmic β-catenin has a protective role in early melanoma development. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_73626322</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73626322</sourcerecordid><originalsourceid>FETCH-LOGICAL-h269t-74c9c5e535711d00c64b8376a2e9f55f3bfe87df699b0c30bb6a8ae295a709af3</originalsourceid><addsrcrecordid>eNpFkNlKxTAQhoso7q8guVGvClmatLmUgxscETx6Xabp5DTSzaR1eS0fxGcy4hGZi5mB7x_--beSfSZlngqu5HacaV6kNBN8LzkI4ZlSljGa7SZ7jGtFGVf7iXvAejZYk6_PdAET9q4nl--jxxDc0JO4TQ2Sxcc0jC2EjgyWXNSv0EdJuppgjWQ1j-itMw5asopCqF2_JnfQunUP_UTusIV-6OAo2bHQBjze9MPk6erycXGTLu-vbxcXy7ThSk9pnhltJEohc8ZqSo3KqkLkCjhqK6UVlcUir63SuqJG0KpSUAByLSGnGqw4TM5-745-eJkxTGXngsE2usBhDmUuFFeC8wiebMC56rAuR-868B_lXzgRON0AEAy01se3XfjnJKNKCha581-ucevmzXkszU9APoaI4E1T6lhCFEJ8A_WNfYg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73626322</pqid></control><display><type>article</type><title>Reduced β-Catenin Expression in the Cytoplasm of Advanced-Stage Superficial Spreading Malignant Melanoma</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>MAELANDSMO, Gunhild M ; HOLM, Ruth ; NESLAND, Jahn M ; FODSTAD, Øystein ; FLØRENES, Vivi Ann</creator><creatorcontrib>MAELANDSMO, Gunhild M ; HOLM, Ruth ; NESLAND, Jahn M ; FODSTAD, Øystein ; FLØRENES, Vivi Ann</creatorcontrib><description>Purpose: The purpose of the present work was to analyze the expression of β-catenin in a panel of superficial and nodular spreading
primary and metastatic melanomas, and to correlate the level of immunohistochemical staining to clinicopathological parameters.
Experimental Design: Expression of β-catenin was examined by immunohistochemistry in 106 superficial and 58 nodular spreading primary melanomas,
as well as in 66 metastatic lesions.
Results: Membrane-associated staining was detected in nearly all of the cases, and no association to clinical parameters could be
revealed. When cytoplasmic localization of the protein was recorded, a significant higher fraction of the superficial than
the nodular spreading primary lesions expressed the protein in the majority of the cells ( P < 0.0001). Interestingly, metastatic lesions from superficial melanomas demonstrated down-regulated expression of the protein,
and in agreement with this a significant inverse correlation between protein expression and the vertical thickness of the
primary lesion was detected ( P = 0.012). Furthermore, a significant correlation between cytoplasmic localization and disease-free survival ( P = 0.0006) was revealed, but β-catenin did not have any significant impact on overall survival for this group of patients
( P = 0.0824). No association was detected between β-catenin expression and clinicopathological parameters in the nodular subgroup
of melanomas, indicating that the protein may play different roles in the malignant progression of the two main types of melanomas.
Conclusion: In summary, we hypothesize that cytoplasmic β-catenin has a protective role in early melanoma development.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>PMID: 12960126</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Aged ; Aged, 80 and over ; beta Catenin ; Biological and medical sciences ; Cell Cycle Proteins - biosynthesis ; Cell Line, Tumor ; Cell Membrane - metabolism ; Cyclin D1 - biosynthesis ; Cyclin-Dependent Kinase Inhibitor p27 ; Cytoplasm - metabolism ; Cytoskeletal Proteins - biosynthesis ; Cytoskeletal Proteins - metabolism ; Dermatology ; Disease-Free Survival ; Humans ; Immunohistochemistry ; Medical sciences ; Melanoma - metabolism ; Melanoma - mortality ; Melanoma - pathology ; Middle Aged ; Neoplasm Metastasis ; Recurrence ; Skin Neoplasms - metabolism ; Skin Neoplasms - mortality ; Skin Neoplasms - pathology ; Time Factors ; Trans-Activators - biosynthesis ; Trans-Activators - metabolism ; Tumor Suppressor Proteins - biosynthesis ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Clinical cancer research, 2003-08, Vol.9 (9), p.3383-3388</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15106531$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12960126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MAELANDSMO, Gunhild M</creatorcontrib><creatorcontrib>HOLM, Ruth</creatorcontrib><creatorcontrib>NESLAND, Jahn M</creatorcontrib><creatorcontrib>FODSTAD, Øystein</creatorcontrib><creatorcontrib>FLØRENES, Vivi Ann</creatorcontrib><title>Reduced β-Catenin Expression in the Cytoplasm of Advanced-Stage Superficial Spreading Malignant Melanoma</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Purpose: The purpose of the present work was to analyze the expression of β-catenin in a panel of superficial and nodular spreading
primary and metastatic melanomas, and to correlate the level of immunohistochemical staining to clinicopathological parameters.
Experimental Design: Expression of β-catenin was examined by immunohistochemistry in 106 superficial and 58 nodular spreading primary melanomas,
as well as in 66 metastatic lesions.
Results: Membrane-associated staining was detected in nearly all of the cases, and no association to clinical parameters could be
revealed. When cytoplasmic localization of the protein was recorded, a significant higher fraction of the superficial than
the nodular spreading primary lesions expressed the protein in the majority of the cells ( P < 0.0001). Interestingly, metastatic lesions from superficial melanomas demonstrated down-regulated expression of the protein,
and in agreement with this a significant inverse correlation between protein expression and the vertical thickness of the
primary lesion was detected ( P = 0.012). Furthermore, a significant correlation between cytoplasmic localization and disease-free survival ( P = 0.0006) was revealed, but β-catenin did not have any significant impact on overall survival for this group of patients
( P = 0.0824). No association was detected between β-catenin expression and clinicopathological parameters in the nodular subgroup
of melanomas, indicating that the protein may play different roles in the malignant progression of the two main types of melanomas.
Conclusion: In summary, we hypothesize that cytoplasmic β-catenin has a protective role in early melanoma development.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>beta Catenin</subject><subject>Biological and medical sciences</subject><subject>Cell Cycle Proteins - biosynthesis</subject><subject>Cell Line, Tumor</subject><subject>Cell Membrane - metabolism</subject><subject>Cyclin D1 - biosynthesis</subject><subject>Cyclin-Dependent Kinase Inhibitor p27</subject><subject>Cytoplasm - metabolism</subject><subject>Cytoskeletal Proteins - biosynthesis</subject><subject>Cytoskeletal Proteins - metabolism</subject><subject>Dermatology</subject><subject>Disease-Free Survival</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Melanoma - metabolism</subject><subject>Melanoma - mortality</subject><subject>Melanoma - pathology</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Recurrence</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - mortality</subject><subject>Skin Neoplasms - pathology</subject><subject>Time Factors</subject><subject>Trans-Activators - biosynthesis</subject><subject>Trans-Activators - metabolism</subject><subject>Tumor Suppressor Proteins - biosynthesis</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkNlKxTAQhoso7q8guVGvClmatLmUgxscETx6Xabp5DTSzaR1eS0fxGcy4hGZi5mB7x_--beSfSZlngqu5HacaV6kNBN8LzkI4ZlSljGa7SZ7jGtFGVf7iXvAejZYk6_PdAET9q4nl--jxxDc0JO4TQ2Sxcc0jC2EjgyWXNSv0EdJuppgjWQ1j-itMw5asopCqF2_JnfQunUP_UTusIV-6OAo2bHQBjze9MPk6erycXGTLu-vbxcXy7ThSk9pnhltJEohc8ZqSo3KqkLkCjhqK6UVlcUir63SuqJG0KpSUAByLSGnGqw4TM5-745-eJkxTGXngsE2usBhDmUuFFeC8wiebMC56rAuR-868B_lXzgRON0AEAy01se3XfjnJKNKCha581-ucevmzXkszU9APoaI4E1T6lhCFEJ8A_WNfYg</recordid><startdate>20030815</startdate><enddate>20030815</enddate><creator>MAELANDSMO, Gunhild M</creator><creator>HOLM, Ruth</creator><creator>NESLAND, Jahn M</creator><creator>FODSTAD, Øystein</creator><creator>FLØRENES, Vivi Ann</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20030815</creationdate><title>Reduced β-Catenin Expression in the Cytoplasm of Advanced-Stage Superficial Spreading Malignant Melanoma</title><author>MAELANDSMO, Gunhild M ; HOLM, Ruth ; NESLAND, Jahn M ; FODSTAD, Øystein ; FLØRENES, Vivi Ann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h269t-74c9c5e535711d00c64b8376a2e9f55f3bfe87df699b0c30bb6a8ae295a709af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>beta Catenin</topic><topic>Biological and medical sciences</topic><topic>Cell Cycle Proteins - biosynthesis</topic><topic>Cell Line, Tumor</topic><topic>Cell Membrane - metabolism</topic><topic>Cyclin D1 - biosynthesis</topic><topic>Cyclin-Dependent Kinase Inhibitor p27</topic><topic>Cytoplasm - metabolism</topic><topic>Cytoskeletal Proteins - biosynthesis</topic><topic>Cytoskeletal Proteins - metabolism</topic><topic>Dermatology</topic><topic>Disease-Free Survival</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>Melanoma - metabolism</topic><topic>Melanoma - mortality</topic><topic>Melanoma - pathology</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Recurrence</topic><topic>Skin Neoplasms - metabolism</topic><topic>Skin Neoplasms - mortality</topic><topic>Skin Neoplasms - pathology</topic><topic>Time Factors</topic><topic>Trans-Activators - biosynthesis</topic><topic>Trans-Activators - metabolism</topic><topic>Tumor Suppressor Proteins - biosynthesis</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAELANDSMO, Gunhild M</creatorcontrib><creatorcontrib>HOLM, Ruth</creatorcontrib><creatorcontrib>NESLAND, Jahn M</creatorcontrib><creatorcontrib>FODSTAD, Øystein</creatorcontrib><creatorcontrib>FLØRENES, Vivi Ann</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MAELANDSMO, Gunhild M</au><au>HOLM, Ruth</au><au>NESLAND, Jahn M</au><au>FODSTAD, Øystein</au><au>FLØRENES, Vivi Ann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced β-Catenin Expression in the Cytoplasm of Advanced-Stage Superficial Spreading Malignant Melanoma</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2003-08-15</date><risdate>2003</risdate><volume>9</volume><issue>9</issue><spage>3383</spage><epage>3388</epage><pages>3383-3388</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Purpose: The purpose of the present work was to analyze the expression of β-catenin in a panel of superficial and nodular spreading
primary and metastatic melanomas, and to correlate the level of immunohistochemical staining to clinicopathological parameters.
Experimental Design: Expression of β-catenin was examined by immunohistochemistry in 106 superficial and 58 nodular spreading primary melanomas,
as well as in 66 metastatic lesions.
Results: Membrane-associated staining was detected in nearly all of the cases, and no association to clinical parameters could be
revealed. When cytoplasmic localization of the protein was recorded, a significant higher fraction of the superficial than
the nodular spreading primary lesions expressed the protein in the majority of the cells ( P < 0.0001). Interestingly, metastatic lesions from superficial melanomas demonstrated down-regulated expression of the protein,
and in agreement with this a significant inverse correlation between protein expression and the vertical thickness of the
primary lesion was detected ( P = 0.012). Furthermore, a significant correlation between cytoplasmic localization and disease-free survival ( P = 0.0006) was revealed, but β-catenin did not have any significant impact on overall survival for this group of patients
( P = 0.0824). No association was detected between β-catenin expression and clinicopathological parameters in the nodular subgroup
of melanomas, indicating that the protein may play different roles in the malignant progression of the two main types of melanomas.
Conclusion: In summary, we hypothesize that cytoplasmic β-catenin has a protective role in early melanoma development.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>12960126</pmid><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over beta Catenin Biological and medical sciences Cell Cycle Proteins - biosynthesis Cell Line, Tumor Cell Membrane - metabolism Cyclin D1 - biosynthesis Cyclin-Dependent Kinase Inhibitor p27 Cytoplasm - metabolism Cytoskeletal Proteins - biosynthesis Cytoskeletal Proteins - metabolism Dermatology Disease-Free Survival Humans Immunohistochemistry Medical sciences Melanoma - metabolism Melanoma - mortality Melanoma - pathology Middle Aged Neoplasm Metastasis Recurrence Skin Neoplasms - metabolism Skin Neoplasms - mortality Skin Neoplasms - pathology Time Factors Trans-Activators - biosynthesis Trans-Activators - metabolism Tumor Suppressor Proteins - biosynthesis Tumors of the skin and soft tissue. Premalignant lesions |
| title | Reduced β-Catenin Expression in the Cytoplasm of Advanced-Stage Superficial Spreading Malignant Melanoma |
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