Lifestyle-related risk factors for Parkinson's disease: a population-based study
Objectives – To investigate the association of major lifestyle‐related risk factors with the prevalent cases of Parkinson's disease (PD) identified by the Italian Longitudinal Study on Aging. Methods – A total of 5632 individuals randomly selected from the population registers of eight center...
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| Veröffentlicht in: | Acta neurologica Scandinavica 2003-10, Vol.108 (4), p.239-244 |
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| container_title | Acta neurologica Scandinavica |
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| creator | Baldereschi, M. Di Carlo, A. Vanni, P. Ghetti, A. Carbonin, P. Amaducci, L. Inzitari, D. |
| description | Objectives – To investigate the association of major lifestyle‐related risk factors with the prevalent cases of Parkinson's disease (PD) identified by the Italian Longitudinal Study on Aging.
Methods – A total of 5632 individuals randomly selected from the population registers of eight centers were screened for parkinsonism using both a questionnaire and a neurologic examination. Screened positives underwent a structured clinical work‐up for the diagnosis of parkinsonism and parkinsonism subtypes.
Results – We identified 113 prevalent cases of PD. Age, male gender, and pesticide‐use license were significantly related to PD. Heavy smoking was inversely related to PD. Age (OR = 1.1; 95% CI, 1.06–1.15) and pesticide‐use license (OR = 3.7; 95% CI, 1.6–8.6) kept their significant correlation with the disease in the multivariate analysis to adjust for all the variables under investigation. Multivariate analyses were made for men and women separately: pesticide exposure was positively associated with PD only in men.
Conclusions – Pesticide exposure might represent a candidate for environmental factors involved in PD. |
| doi_str_mv | 10.1034/j.1600-0404.2003.00128.x |
| format | Article |
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Methods – A total of 5632 individuals randomly selected from the population registers of eight centers were screened for parkinsonism using both a questionnaire and a neurologic examination. Screened positives underwent a structured clinical work‐up for the diagnosis of parkinsonism and parkinsonism subtypes.
Results – We identified 113 prevalent cases of PD. Age, male gender, and pesticide‐use license were significantly related to PD. Heavy smoking was inversely related to PD. Age (OR = 1.1; 95% CI, 1.06–1.15) and pesticide‐use license (OR = 3.7; 95% CI, 1.6–8.6) kept their significant correlation with the disease in the multivariate analysis to adjust for all the variables under investigation. Multivariate analyses were made for men and women separately: pesticide exposure was positively associated with PD only in men.
Conclusions – Pesticide exposure might represent a candidate for environmental factors involved in PD.</description><identifier>ISSN: 0001-6314</identifier><identifier>EISSN: 1600-0404</identifier><identifier>DOI: 10.1034/j.1600-0404.2003.00128.x</identifier><identifier>PMID: 12956856</identifier><identifier>CODEN: ANRSAS</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Aged ; Aged, 80 and over ; Aging - physiology ; Biological and medical sciences ; Cross-Sectional Studies ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Humans ; Italy - epidemiology ; Life Style ; Longitudinal Studies ; Male ; Medical sciences ; Neurology ; Parkinson Disease - epidemiology ; Parkinson Disease - etiology ; Parkinson Disease - physiopathology ; Parkinson's disease ; pesticide ; Prevalence ; Risk Factors ; Risk-Taking</subject><ispartof>Acta neurologica Scandinavica, 2003-10, Vol.108 (4), p.239-244</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4338-41ee36552f2efaa6801ccebe9161df9b53f4e182eec3b2e08b95ca2b8780444e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1034%2Fj.1600-0404.2003.00128.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1600-0404.2003.00128.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15106098$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12956856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baldereschi, M.</creatorcontrib><creatorcontrib>Di Carlo, A.</creatorcontrib><creatorcontrib>Vanni, P.</creatorcontrib><creatorcontrib>Ghetti, A.</creatorcontrib><creatorcontrib>Carbonin, P.</creatorcontrib><creatorcontrib>Amaducci, L.</creatorcontrib><creatorcontrib>Inzitari, D.</creatorcontrib><creatorcontrib>Italian Longitudinal Study on Aging Working Group</creatorcontrib><title>Lifestyle-related risk factors for Parkinson's disease: a population-based study</title><title>Acta neurologica Scandinavica</title><addtitle>Acta Neurol Scand</addtitle><description>Objectives – To investigate the association of major lifestyle‐related risk factors with the prevalent cases of Parkinson's disease (PD) identified by the Italian Longitudinal Study on Aging.
Methods – A total of 5632 individuals randomly selected from the population registers of eight centers were screened for parkinsonism using both a questionnaire and a neurologic examination. Screened positives underwent a structured clinical work‐up for the diagnosis of parkinsonism and parkinsonism subtypes.
Results – We identified 113 prevalent cases of PD. Age, male gender, and pesticide‐use license were significantly related to PD. Heavy smoking was inversely related to PD. Age (OR = 1.1; 95% CI, 1.06–1.15) and pesticide‐use license (OR = 3.7; 95% CI, 1.6–8.6) kept their significant correlation with the disease in the multivariate analysis to adjust for all the variables under investigation. Multivariate analyses were made for men and women separately: pesticide exposure was positively associated with PD only in men.
Conclusions – Pesticide exposure might represent a candidate for environmental factors involved in PD.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Life Style</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson Disease - etiology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>pesticide</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Risk-Taking</subject><issn>0001-6314</issn><issn>1600-0404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1v1DAQhi0EotvCX0C-AKcEf8dBXKrSlo-l7AG0EhfLccaSt9lksROx--9x2KU9zWjmeUea90UIU1JSwsW7TUkVIQURRJSMEF4SQpku90_Q4mHxFC1IHheKU3GGzlPazFAlxHN0RlktlZZqgVbL4CGNhw6KCJ0docUxpHvsrRuHmLAfIl7ZeB_6NPRvE25DApvgPbZ4N-ymrAhDXzR51OI0Tu3hBXrmbZfg5aleoJ831z-uPhXL77efry6XhROc60JQAK6kZJ6Bt1ZpQp2DBmqqaOvrRnIvgGoG4HjDgOimls6yRleaCCGAX6A3x7u7OPye8gtmG5KDrrM9DFMyFVdMUqky-OoETs0WWrOLYWvjwfz3IAOvT4BNznY-2t6F9MhJShSpdeY-HLk_oYPD456YOROzMbP1ZrbezJmYf5mYvbm8u85NlhdHeUgj7B_k2VujKl5Js767Nd_WH7-uf9EvZsX_AkiSjj8</recordid><startdate>200310</startdate><enddate>200310</enddate><creator>Baldereschi, M.</creator><creator>Di Carlo, A.</creator><creator>Vanni, P.</creator><creator>Ghetti, A.</creator><creator>Carbonin, P.</creator><creator>Amaducci, L.</creator><creator>Inzitari, D.</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200310</creationdate><title>Lifestyle-related risk factors for Parkinson's disease: a population-based study</title><author>Baldereschi, M. ; Di Carlo, A. ; Vanni, P. ; Ghetti, A. ; Carbonin, P. ; Amaducci, L. ; Inzitari, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4338-41ee36552f2efaa6801ccebe9161df9b53f4e182eec3b2e08b95ca2b8780444e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Italy - epidemiology</topic><topic>Life Style</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson Disease - etiology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson's disease</topic><topic>pesticide</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Risk-Taking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baldereschi, M.</creatorcontrib><creatorcontrib>Di Carlo, A.</creatorcontrib><creatorcontrib>Vanni, P.</creatorcontrib><creatorcontrib>Ghetti, A.</creatorcontrib><creatorcontrib>Carbonin, P.</creatorcontrib><creatorcontrib>Amaducci, L.</creatorcontrib><creatorcontrib>Inzitari, D.</creatorcontrib><creatorcontrib>Italian Longitudinal Study on Aging Working Group</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neurologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baldereschi, M.</au><au>Di Carlo, A.</au><au>Vanni, P.</au><au>Ghetti, A.</au><au>Carbonin, P.</au><au>Amaducci, L.</au><au>Inzitari, D.</au><aucorp>Italian Longitudinal Study on Aging Working Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lifestyle-related risk factors for Parkinson's disease: a population-based study</atitle><jtitle>Acta neurologica Scandinavica</jtitle><addtitle>Acta Neurol Scand</addtitle><date>2003-10</date><risdate>2003</risdate><volume>108</volume><issue>4</issue><spage>239</spage><epage>244</epage><pages>239-244</pages><issn>0001-6314</issn><eissn>1600-0404</eissn><coden>ANRSAS</coden><abstract>Objectives – To investigate the association of major lifestyle‐related risk factors with the prevalent cases of Parkinson's disease (PD) identified by the Italian Longitudinal Study on Aging.
Methods – A total of 5632 individuals randomly selected from the population registers of eight centers were screened for parkinsonism using both a questionnaire and a neurologic examination. Screened positives underwent a structured clinical work‐up for the diagnosis of parkinsonism and parkinsonism subtypes.
Results – We identified 113 prevalent cases of PD. Age, male gender, and pesticide‐use license were significantly related to PD. Heavy smoking was inversely related to PD. Age (OR = 1.1; 95% CI, 1.06–1.15) and pesticide‐use license (OR = 3.7; 95% CI, 1.6–8.6) kept their significant correlation with the disease in the multivariate analysis to adjust for all the variables under investigation. Multivariate analyses were made for men and women separately: pesticide exposure was positively associated with PD only in men.
Conclusions – Pesticide exposure might represent a candidate for environmental factors involved in PD.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>12956856</pmid><doi>10.1034/j.1600-0404.2003.00128.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Aged, 80 and over Aging - physiology Biological and medical sciences Cross-Sectional Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Italy - epidemiology Life Style Longitudinal Studies Male Medical sciences Neurology Parkinson Disease - epidemiology Parkinson Disease - etiology Parkinson Disease - physiopathology Parkinson's disease pesticide Prevalence Risk Factors Risk-Taking |
| title | Lifestyle-related risk factors for Parkinson's disease: a population-based study |
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