Stereochemical heterogeneity of hepatic UDP-glucuronosyltransferase activity in rat liver microsomes

Rat liver UDP glucuronosyltransferase activities may be divided into at least two groups with differential responses towards substrates. This paper deals with an attempt to describe on what chemical basis the two groups may be distinguished. We studied the glucuronidation of 24 substrates in liver-m...

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Veröffentlicht in:	Biochemical pharmacology 1981-06, Vol.30 (12), p.1457-1461
Hauptverfasser:	Okulicz-Kozaryn, Iréna, Schaefer, Michel, Batt, Anne-Marie, Siest, Gérard, Loppinet, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Glucuronosyltransferase - metabolism In Vitro Techniques Male Methylcholanthrene - pharmacology Microsomes, Liver - drug effects Microsomes, Liver - enzymology Molecular Conformation Phenobarbital - pharmacology Rats Stereoisomerism Structure-Activity Relationship Substrate Specificity
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