In Vivo Antitumor Activity of NKT Cells Activated by the Combination of IL-12 and IL-18

Interleukin-12 and IL-18 have been demonstrated to potentiate innate immunity in a variety of experimental tumor models, but the functional roles of NK and/or NKT cells and their mechanism of action in these models have not been fully addressed. Through adoptive transfer of NKT cells activated in vi...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-09, Vol.171 (6), p.2953-2959
Hauptverfasser:	Baxevanis, Constantin N, Gritzapis, Angelos D, Papamichail, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Antigens - biosynthesis Antigens, Surface Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - pharmacology CD3 Complex - biosynthesis Cell Line, Tumor Cells, Cultured Cytotoxicity, Immunologic Fibrosarcoma - pathology Fibrosarcoma - prevention & control Growth Inhibitors - administration & dosage Growth Inhibitors - pharmacology Interferon-gamma - biosynthesis Interferon-gamma - physiology Interleukin-12 - administration & dosage Interleukin-12 - pharmacology Interleukin-18 - administration & dosage Interleukin-18 - pharmacology Interleukin-2 - biosynthesis Interleukin-2 - physiology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Killer Cells, Natural - transplantation Lectins, C-Type Lymphocyte Activation - immunology Lymphoma, T-Cell - immunology Lymphoma, T-Cell - pathology Lymphoma, T-Cell - prevention & control Mice Mice, Inbred C57BL Mice, SCID Neoplasm Transplantation NK Cell Lectin-Like Receptor Subfamily B Protein Biosynthesis Proteins T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - transplantation
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