Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization

Mdm2 is a nucleoplasmic and nucleolar protein interacting with p53 and alternative reading frame (ARF) tumor suppressor proteins. Here we demonstrate relocalization and novel interactions of Mdm2 with the promyelocytic leukemia (PML) protein following cellular stress and DNA damage. We show that Mdm...

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Veröffentlicht in:	Journal of cell science 2003-10, Vol.116 (Pt 19), p.3917-3925
Hauptverfasser:	Kurki, Sari, Latonen, Leena, Laiho, Marikki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenicals - pharmacology Cells, Cultured Cyclin-Dependent Kinase Inhibitor p16 DNA Damage - physiology DNA Damage - radiation effects Humans Mice Microscopy, Fluorescence Nuclear Matrix - drug effects Nuclear Matrix - metabolism Nuclear Matrix - radiation effects Nuclear Proteins - metabolism Oxides - pharmacology Protein Binding - drug effects Protein Binding - radiation effects Protein Structure, Tertiary Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-mdm2 Tumor Suppressor Protein p14ARF - metabolism Tumor Suppressor Protein p53 - metabolism Ultraviolet Rays
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