Morphometric intratumoral microvessel area evaluation could be a useful indicator for coadjuvant therapy in ressected NSCLC
To accomplish the tumor vascular area measure and the microvessel count, shown by immunohistochemistry, in non small cell lung cancer (NSCLC) microscopic images, and verify the correlation between these measurements and patients survival. cross-sectional and observational. The material was deriving...
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| Veröffentlicht in: | Revista portuguesa de pneumologia 2003-01, Vol.9 (1), p.19-32 |
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| creator | Irion, Luciane Cristina Dreher Prolla, João Carlos Hartmann, Antônio Atalíbio da Silva, Vinícius Duval |
| description | To accomplish the tumor vascular area measure and the microvessel count, shown by immunohistochemistry, in non small cell lung cancer (NSCLC) microscopic images, and verify the correlation between these measurements and patients survival.
cross-sectional and observational.
The material was deriving from 107 NSCLC surgical specimens in Pavilhão Pereira Filho Santa Casa, Porto Alegre. Immunohistochemistry with anti-CD 34 monoclonal antibody (QB-End10; DAKO Corporation) was performed on paraffin-embedded tissue sections. The tumoral vascular area and the microvessel count were obtained by Image Pro Plus 3.0 program.
The 5-year survival rate of high vascular area group (the cut-off was the mean of areas) was 21.7 months +/- 2.5, significantly lower (P < 0.0001) than the low vascular area cases, 38.9 months +/- 3.0. The correlation coefficient between microvessel area and microvessel count was 0.5 (P = 0.001). The tumoral vascular area shown higher correlation to survival (correlation coefficient: 0.48 / P = 0.001) than the tumoral microvessel count (correlation coefficient: 0.2 / P = 0.03). There was not any significant correlation between the microvessel areas and the histological type, the TNM, the lymph nodes status and the clinical staging.
The tumoral vascular area measurement, with computed assistance, can be used as a prognostic marker in NSCLC. |
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cross-sectional and observational.
The material was deriving from 107 NSCLC surgical specimens in Pavilhão Pereira Filho Santa Casa, Porto Alegre. Immunohistochemistry with anti-CD 34 monoclonal antibody (QB-End10; DAKO Corporation) was performed on paraffin-embedded tissue sections. The tumoral vascular area and the microvessel count were obtained by Image Pro Plus 3.0 program.
The 5-year survival rate of high vascular area group (the cut-off was the mean of areas) was 21.7 months +/- 2.5, significantly lower (P < 0.0001) than the low vascular area cases, 38.9 months +/- 3.0. The correlation coefficient between microvessel area and microvessel count was 0.5 (P = 0.001). The tumoral vascular area shown higher correlation to survival (correlation coefficient: 0.48 / P = 0.001) than the tumoral microvessel count (correlation coefficient: 0.2 / P = 0.03). There was not any significant correlation between the microvessel areas and the histological type, the TNM, the lymph nodes status and the clinical staging.
The tumoral vascular area measurement, with computed assistance, can be used as a prognostic marker in NSCLC.</description><identifier>ISSN: 0873-2159</identifier><identifier>PMID: 12958665</identifier><language>por</language><publisher>Spain</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung - blood supply ; Carcinoma, Non-Small-Cell Lung - mortality ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Non-Small-Cell Lung - surgery ; Combined Modality Therapy ; Female ; Humans ; Lung Neoplasms - blood supply ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Lung Neoplasms - surgery ; Male ; Microcirculation ; Middle Aged ; Survival Rate</subject><ispartof>Revista portuguesa de pneumologia, 2003-01, Vol.9 (1), p.19-32</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12958665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Irion, Luciane Cristina Dreher</creatorcontrib><creatorcontrib>Prolla, João Carlos</creatorcontrib><creatorcontrib>Hartmann, Antônio Atalíbio</creatorcontrib><creatorcontrib>da Silva, Vinícius Duval</creatorcontrib><title>Morphometric intratumoral microvessel area evaluation could be a useful indicator for coadjuvant therapy in ressected NSCLC</title><title>Revista portuguesa de pneumologia</title><addtitle>Rev Port Pneumol</addtitle><description>To accomplish the tumor vascular area measure and the microvessel count, shown by immunohistochemistry, in non small cell lung cancer (NSCLC) microscopic images, and verify the correlation between these measurements and patients survival.
cross-sectional and observational.
The material was deriving from 107 NSCLC surgical specimens in Pavilhão Pereira Filho Santa Casa, Porto Alegre. Immunohistochemistry with anti-CD 34 monoclonal antibody (QB-End10; DAKO Corporation) was performed on paraffin-embedded tissue sections. The tumoral vascular area and the microvessel count were obtained by Image Pro Plus 3.0 program.
The 5-year survival rate of high vascular area group (the cut-off was the mean of areas) was 21.7 months +/- 2.5, significantly lower (P < 0.0001) than the low vascular area cases, 38.9 months +/- 3.0. The correlation coefficient between microvessel area and microvessel count was 0.5 (P = 0.001). The tumoral vascular area shown higher correlation to survival (correlation coefficient: 0.48 / P = 0.001) than the tumoral microvessel count (correlation coefficient: 0.2 / P = 0.03). There was not any significant correlation between the microvessel areas and the histological type, the TNM, the lymph nodes status and the clinical staging.
The tumoral vascular area measurement, with computed assistance, can be used as a prognostic marker in NSCLC.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Non-Small-Cell Lung - blood supply</subject><subject>Carcinoma, Non-Small-Cell Lung - mortality</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - surgery</subject><subject>Combined Modality Therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - blood supply</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Microcirculation</subject><subject>Middle Aged</subject><subject>Survival Rate</subject><issn>0873-2159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kDtPwzAUhTOAaCn8BeSJLZIfcRKPKOIlFRjoHt3YN2oqJw5-VKr48wRRhqOzfOcbzkW2pnUlcs6kWmXXIRwoLWTFq6tsxbiSdVnKdfb95vy8dyNGP2gyTNFDTKPzYMk4aO-OGAJaAh6B4BFsgji4iWiXrCEdEiApYJ_sMjWDhug86ZdoB-aQjjBFEvfoYT4tAPG_Mh3RkPfPZtvcZJc92IC3595ku6fHXfOSbz-eX5uHbT7LQuYgeKkKJqkUUnDaK6QVaORaUNbVpqiV0LLsJWOoOqRF1RsJqip6U1RMGyY22f2fdvbuK2GI7TgEjdbChC6FthIl51wVC3h3BlM3omlnP4zgT-3_W-IHwXZnUg</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Irion, Luciane Cristina Dreher</creator><creator>Prolla, João Carlos</creator><creator>Hartmann, Antônio Atalíbio</creator><creator>da Silva, Vinícius Duval</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200301</creationdate><title>Morphometric intratumoral microvessel area evaluation could be a useful indicator for coadjuvant therapy in ressected NSCLC</title><author>Irion, Luciane Cristina Dreher ; Prolla, João Carlos ; Hartmann, Antônio Atalíbio ; da Silva, Vinícius Duval</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p545-a32694150535320f9e07ace2c301b8d4893c56f511e9be047fd5a974fd471cd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>por</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Non-Small-Cell Lung - blood supply</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Non-Small-Cell Lung - surgery</topic><topic>Combined Modality Therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - blood supply</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Microcirculation</topic><topic>Middle Aged</topic><topic>Survival Rate</topic><toplevel>online_resources</toplevel><creatorcontrib>Irion, Luciane Cristina Dreher</creatorcontrib><creatorcontrib>Prolla, João Carlos</creatorcontrib><creatorcontrib>Hartmann, Antônio Atalíbio</creatorcontrib><creatorcontrib>da Silva, Vinícius Duval</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Revista portuguesa de pneumologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Irion, Luciane Cristina Dreher</au><au>Prolla, João Carlos</au><au>Hartmann, Antônio Atalíbio</au><au>da Silva, Vinícius Duval</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphometric intratumoral microvessel area evaluation could be a useful indicator for coadjuvant therapy in ressected NSCLC</atitle><jtitle>Revista portuguesa de pneumologia</jtitle><addtitle>Rev Port Pneumol</addtitle><date>2003-01</date><risdate>2003</risdate><volume>9</volume><issue>1</issue><spage>19</spage><epage>32</epage><pages>19-32</pages><issn>0873-2159</issn><abstract>To accomplish the tumor vascular area measure and the microvessel count, shown by immunohistochemistry, in non small cell lung cancer (NSCLC) microscopic images, and verify the correlation between these measurements and patients survival.
cross-sectional and observational.
The material was deriving from 107 NSCLC surgical specimens in Pavilhão Pereira Filho Santa Casa, Porto Alegre. Immunohistochemistry with anti-CD 34 monoclonal antibody (QB-End10; DAKO Corporation) was performed on paraffin-embedded tissue sections. The tumoral vascular area and the microvessel count were obtained by Image Pro Plus 3.0 program.
The 5-year survival rate of high vascular area group (the cut-off was the mean of areas) was 21.7 months +/- 2.5, significantly lower (P < 0.0001) than the low vascular area cases, 38.9 months +/- 3.0. The correlation coefficient between microvessel area and microvessel count was 0.5 (P = 0.001). The tumoral vascular area shown higher correlation to survival (correlation coefficient: 0.48 / P = 0.001) than the tumoral microvessel count (correlation coefficient: 0.2 / P = 0.03). There was not any significant correlation between the microvessel areas and the histological type, the TNM, the lymph nodes status and the clinical staging.
The tumoral vascular area measurement, with computed assistance, can be used as a prognostic marker in NSCLC.</abstract><cop>Spain</cop><pmid>12958665</pmid><tpages>14</tpages></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Carcinoma, Non-Small-Cell Lung - blood supply Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Combined Modality Therapy Female Humans Lung Neoplasms - blood supply Lung Neoplasms - mortality Lung Neoplasms - pathology Lung Neoplasms - surgery Male Microcirculation Middle Aged Survival Rate |
| title | Morphometric intratumoral microvessel area evaluation could be a useful indicator for coadjuvant therapy in ressected NSCLC |
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