Membrane fusion: a structural perspective on the interplay of lipids and proteins
The fusion of biological membranes is governed by the carefully orchestrated interplay of membrane proteins and lipids. Recently determined structures of fusion proteins, individual domains of fusion proteins and their complexes with regulatory proteins and membrane lipids have yielded much suggesti...
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| Veröffentlicht in: | Current opinion in structural biology 2003-08, Vol.13 (4), p.453-466 |
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| container_title | Current opinion in structural biology |
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| creator | Tamm, Lukas K Crane, Jonathan Kiessling, Volker |
| description | The fusion of biological membranes is governed by the carefully orchestrated interplay of membrane proteins and lipids. Recently determined structures of fusion proteins, individual domains of fusion proteins and their complexes with regulatory proteins and membrane lipids have yielded much suggestive insight into how viral and intracellular membrane fusion might proceed. These structures may be combined with new knowledge on the fusion of pure lipid bilayer membranes in an attempt to begin to piece together the complex puzzle of how biological membrane fusion machines operate on membranes. |
| doi_str_mv | 10.1016/S0959-440X(03)00107-6 |
| format | Article |
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| ispartof | Current opinion in structural biology, 2003-08, Vol.13 (4), p.453-466 |
| issn | 0959-440X 1879-033X |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Lipids - chemistry Lipids - physiology Membrane Fusion - physiology Membrane Proteins - chemistry Membrane Proteins - physiology Orthomyxoviridae - chemistry Orthomyxoviridae - physiology SNARE Proteins Vesicular Transport Proteins |
| title | Membrane fusion: a structural perspective on the interplay of lipids and proteins |
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