The pkr kinase promoter binds both Sp1 and Sp3, but only Sp3 functions as part of the interferon-inducible complex with ISGF-3 proteins

The protein kinase regulated by RNA (PKR) is an important mediator of the antiviral and antiproliferative actions of interferon (IFN). The promoter of the PKR gene contains a novel 15-bp element designated KCS that is required for both basal and IFN-inducible transcription, with KCS function depende...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2003-09, Vol.313 (2), p.553-566
Hauptverfasser:	Ward, Simone Visosky, Samuel, Charles E
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism eIF-2 Kinase - genetics eIF-2 Kinase - metabolism Humans Interferon-alpha - pharmacology Interferon-gamma - pharmacology Interferon-Stimulated Gene Factor 3 Interferon-Stimulated Gene Factor 3, gamma Subunit Interferons - pharmacology Promoter Regions, Genetic Signal Transduction Sp1 Transcription Factor - metabolism Sp3 Transcription Factor STAT1 Transcription Factor STAT2 Transcription Factor Trans-Activators - metabolism Transcription Factors - chemistry Transcription Factors - metabolism
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