Comparison of Hyperbaric Oxygen and Misonidazole in Fractionated Irradiation of Murine Tumors
The enhancement ratios for hyperbaric oxygen (${\rm O}_{2}3{\rm ATA}$) and for misonidazole (0.3 mg/g body wt) for fractionated irradiation (5 or 10 equal doses) of two spontaneous tumors and of normal skin of the C3H mouse have been determined. The two tumors were a C3H mouse mammary carcinoma and...
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| Veröffentlicht in: | Radiation research 1981-08, Vol.87 (2), p.360-367 |
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| container_title | Radiation research |
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| creator | Suit, Herman D. Maimonis, Peter Michaels, Howard B. Sedlacek, Robert |
| description | The enhancement ratios for hyperbaric oxygen (${\rm O}_{2}3{\rm ATA}$) and for misonidazole (0.3 mg/g body wt) for fractionated irradiation (5 or 10 equal doses) of two spontaneous tumors and of normal skin of the C3H mouse have been determined. The two tumors were a C3H mouse mammary carcinoma and a squamous cell carcinoma; they were used as third-generation isotransplants and were 8 and 6 mm in diameter, respectively, and grew in the right leg. Acute skin reactions were scored for mice irradiated 18 days after plucking hair from the leg. Enhancement ratios for the ${\rm TCD}_{50}$ values were virtually the same for ${\rm O}_{2}3{\rm ATA}$ and misonidazole, 1.45-1.55. For acute skin reaction the enhancement ratio was higher for ${\rm O}_{2}3{\rm ATA}$, i.e., 1.94 vs 1.54 for misonidazole. |
| doi_str_mv | 10.2307/3575590 |
| format | Article |
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The two tumors were a C3H mouse mammary carcinoma and a squamous cell carcinoma; they were used as third-generation isotransplants and were 8 and 6 mm in diameter, respectively, and grew in the right leg. Acute skin reactions were scored for mice irradiated 18 days after plucking hair from the leg. Enhancement ratios for the ${\rm TCD}_{50}$ values were virtually the same for ${\rm O}_{2}3{\rm ATA}$ and misonidazole, 1.45-1.55. For acute skin reaction the enhancement ratio was higher for ${\rm O}_{2}3{\rm ATA}$, i.e., 1.94 vs 1.54 for misonidazole.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3575590</identifier><identifier>PMID: 7268001</identifier><language>eng</language><publisher>United States: Academic Press, Inc</publisher><subject>Animals ; Cancer ; Carcinoma ; Carcinoma, Squamous Cell - radiotherapy ; Dose fractionation ; Female ; Hyperbaric Oxygenation ; Hypoxia ; Irradiation ; Male ; Mammary Neoplasms, Experimental - radiotherapy ; Mice ; Mice, Inbred C3H ; Misonidazole - pharmacology ; Neoplasm Transplantation ; Nitroimidazoles - pharmacology ; Oxygen ; Radiotherapy ; Skin - radiation effects ; Space life sciences ; Squamous cell carcinoma ; Tumors</subject><ispartof>Radiation research, 1981-08, Vol.87 (2), p.360-367</ispartof><rights>Copyright 1981 Academic Press, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-eee0ca6f5c3d937a4fcd83fb7e8c6ecb0fcb605bca3c1e39efd06c5a9a013f913</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3575590$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3575590$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7268001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suit, Herman D.</creatorcontrib><creatorcontrib>Maimonis, Peter</creatorcontrib><creatorcontrib>Michaels, Howard B.</creatorcontrib><creatorcontrib>Sedlacek, Robert</creatorcontrib><title>Comparison of Hyperbaric Oxygen and Misonidazole in Fractionated Irradiation of Murine Tumors</title><title>Radiation research</title><addtitle>Radiat Res</addtitle><description>The enhancement ratios for hyperbaric oxygen (${\rm O}_{2}3{\rm ATA}$) and for misonidazole (0.3 mg/g body wt) for fractionated irradiation (5 or 10 equal doses) of two spontaneous tumors and of normal skin of the C3H mouse have been determined. The two tumors were a C3H mouse mammary carcinoma and a squamous cell carcinoma; they were used as third-generation isotransplants and were 8 and 6 mm in diameter, respectively, and grew in the right leg. Acute skin reactions were scored for mice irradiated 18 days after plucking hair from the leg. Enhancement ratios for the ${\rm TCD}_{50}$ values were virtually the same for ${\rm O}_{2}3{\rm ATA}$ and misonidazole, 1.45-1.55. For acute skin reaction the enhancement ratio was higher for ${\rm O}_{2}3{\rm ATA}$, i.e., 1.94 vs 1.54 for misonidazole.</description><subject>Animals</subject><subject>Cancer</subject><subject>Carcinoma</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Dose fractionation</subject><subject>Female</subject><subject>Hyperbaric Oxygenation</subject><subject>Hypoxia</subject><subject>Irradiation</subject><subject>Male</subject><subject>Mammary Neoplasms, Experimental - radiotherapy</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Misonidazole - pharmacology</subject><subject>Neoplasm Transplantation</subject><subject>Nitroimidazoles - pharmacology</subject><subject>Oxygen</subject><subject>Radiotherapy</subject><subject>Skin - radiation effects</subject><subject>Space life sciences</subject><subject>Squamous cell carcinoma</subject><subject>Tumors</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFLwzAchYMoc07xLxByED1Vk6ZJmqMMp4ONXeZRSpr-Ih1tM5MWnH-9LSvexNPj8T6-w0PompKHmBH5yLjkXJETNKWKpRFPSHKKpoQwFkmeynN0EcKO9J0KNUETGYuUEDpF73NX77Uvg2uws_j1sAef993gzdfhAxqsmwKvh7ks9LerAJcNXnht2tI1uoUCL73XRamHPhjWnS8bwNuudj5cojOrqwBXY87Q2-J5O3-NVpuX5fxpFZmExG0EAMRoYblhhWJSJ9YUKbO5hNQIMDmxJheE50YzQ4EpsAURhmulCWVWUTZDd0fv3rvPDkKb1WUwUFW6AdeFTDJBFaXsX5DyOBVSJT14fwSNdyF4sNnel7X2h4ySbHg8Gx_vyZtR2eU1FL_ceHG_3x73XWid_1PzAwphh9Y</recordid><startdate>198108</startdate><enddate>198108</enddate><creator>Suit, Herman D.</creator><creator>Maimonis, Peter</creator><creator>Michaels, Howard B.</creator><creator>Sedlacek, Robert</creator><general>Academic Press, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>198108</creationdate><title>Comparison of Hyperbaric Oxygen and Misonidazole in Fractionated Irradiation of Murine Tumors</title><author>Suit, Herman D. ; Maimonis, Peter ; Michaels, Howard B. ; Sedlacek, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-eee0ca6f5c3d937a4fcd83fb7e8c6ecb0fcb605bca3c1e39efd06c5a9a013f913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Cancer</topic><topic>Carcinoma</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Dose fractionation</topic><topic>Female</topic><topic>Hyperbaric Oxygenation</topic><topic>Hypoxia</topic><topic>Irradiation</topic><topic>Male</topic><topic>Mammary Neoplasms, Experimental - radiotherapy</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Misonidazole - pharmacology</topic><topic>Neoplasm Transplantation</topic><topic>Nitroimidazoles - pharmacology</topic><topic>Oxygen</topic><topic>Radiotherapy</topic><topic>Skin - radiation effects</topic><topic>Space life sciences</topic><topic>Squamous cell carcinoma</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suit, Herman D.</creatorcontrib><creatorcontrib>Maimonis, Peter</creatorcontrib><creatorcontrib>Michaels, Howard B.</creatorcontrib><creatorcontrib>Sedlacek, Robert</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suit, Herman D.</au><au>Maimonis, Peter</au><au>Michaels, Howard B.</au><au>Sedlacek, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Hyperbaric Oxygen and Misonidazole in Fractionated Irradiation of Murine Tumors</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>1981-08</date><risdate>1981</risdate><volume>87</volume><issue>2</issue><spage>360</spage><epage>367</epage><pages>360-367</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>The enhancement ratios for hyperbaric oxygen (${\rm O}_{2}3{\rm ATA}$) and for misonidazole (0.3 mg/g body wt) for fractionated irradiation (5 or 10 equal doses) of two spontaneous tumors and of normal skin of the C3H mouse have been determined. The two tumors were a C3H mouse mammary carcinoma and a squamous cell carcinoma; they were used as third-generation isotransplants and were 8 and 6 mm in diameter, respectively, and grew in the right leg. Acute skin reactions were scored for mice irradiated 18 days after plucking hair from the leg. Enhancement ratios for the ${\rm TCD}_{50}$ values were virtually the same for ${\rm O}_{2}3{\rm ATA}$ and misonidazole, 1.45-1.55. For acute skin reaction the enhancement ratio was higher for ${\rm O}_{2}3{\rm ATA}$, i.e., 1.94 vs 1.54 for misonidazole.</abstract><cop>United States</cop><pub>Academic Press, Inc</pub><pmid>7268001</pmid><doi>10.2307/3575590</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-7587 |
| ispartof | Radiation research, 1981-08, Vol.87 (2), p.360-367 |
| issn | 0033-7587 1938-5404 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73619113 |
| source | Jstor Complete Legacy; MEDLINE |
| subjects | Animals Cancer Carcinoma Carcinoma, Squamous Cell - radiotherapy Dose fractionation Female Hyperbaric Oxygenation Hypoxia Irradiation Male Mammary Neoplasms, Experimental - radiotherapy Mice Mice, Inbred C3H Misonidazole - pharmacology Neoplasm Transplantation Nitroimidazoles - pharmacology Oxygen Radiotherapy Skin - radiation effects Space life sciences Squamous cell carcinoma Tumors |
| title | Comparison of Hyperbaric Oxygen and Misonidazole in Fractionated Irradiation of Murine Tumors |
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