Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator γ‐hydroxybutyrate

ABSTRACT γ‐Hydroxybutyrate (GHB) is an endogenous neuromodulator with therapeutical applications in anesthesia, sleep disorders, and drug addiction. We report the cloning of a GHB receptor from a rat hippocampal cDNA library. This receptor has a molecular mass of 56 kDa and belongs to the seven‐tran...

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Veröffentlicht in:	The FASEB journal 2003-09, Vol.17 (12), p.1691-1693
Hauptverfasser:	Andriamampandry, Christian, Taleb, Omar, Viry, Sandrine, Muller, Claude, Humbert, Jean Paul, Gobaille, Serge, Aunis, Dominique, Maitre, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Chemistry CHO Cells Cloning, Molecular Cricetinae drug of abuse GHB Humans Patch-Clamp Techniques Protein Structure, Secondary Rats receptor for neuromodulator Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism RNA, Messenger - analysis Sequence Homology, Amino Acid sleep regulation Sodium Oxybate - metabolism Transfection
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