Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition

Background & Aims : The mechanical origins of the obstruction in sinusoidal obstruction syndrome are initiated by dehiscence of sinusoidal endothelial cells from the space of Disse. The biochemical changes that permit the dehiscence of the sinusoidal endothelial cells were investigated. Methods...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2003-09, Vol.125 (3), p.882-890
Hauptverfasser:	DeLeve, Laurie D., Wang, Xiangdong, Tsai, Jeffrey, Kanel, Gary, Strasberg, Steven, Tokes, Zoltan A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - chemistry Animals Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Hepatic Veno-Occlusive Disease - prevention & control Male Matrix Metalloproteinase Inhibitors Medical sciences Monocrotaline Protease Inhibitors - therapeutic use Rats Rats, Sprague-Dawley
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