Localization and characterization of N-ethylmaleimide sensitive inhibitor(s) of thiol cathepsin activity from cultured nil and polyoma virus-transformed Nil hamster cells

Exposure of cultured Nil (a stable line of fibroblast cells from Syrian hamsters) or polyoma virus‐transformed (PyNil) hamster fibroblasts to 0.5 mM N‐ethylmaleimide for 5 minutes resulted in striking increases in thiol cathepsin activity in unfractionated cell‐free lysates. The paradoxical increase...

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