Glycolysis and glucose transporter 1 as markers of response to hormonal therapy in breast cancer

Estrogen plays a key role in the development and progression of breast cancer; hence, antiestrogens, such as tamoxifen, have a marked impact on the treatment and outcome of breast cancer patients. Estrogen‐induced growth requires continuous replenishment of energy, predominantly generated by glycoly...

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Veröffentlicht in:	International journal of cancer 2003-11, Vol.107 (2), p.177-182
Hauptverfasser:	Rivenzon‐Segal, Dalia, Boldin‐Adamsky, Swetlana, Seger, Dalia, Seger, Rony, Degani, Hadassa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents, Hormonal - therapeutic use Biological and medical sciences Biomarkers, Tumor - metabolism breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cell Division - drug effects Chemotherapy Disease Models, Animal Down-Regulation estrogen Estrogens - therapeutic use Female glucose Glucose - metabolism Glucose Transporter Type 1 Glycolysis Humans lactate Magnetic Resonance Imaging magnetic resonance spectroscopy Medical sciences Mice Mice, Nude Monosaccharide Transport Proteins - metabolism Neoplasms, Hormone-Dependent - drug therapy Neoplasms, Hormone-Dependent - metabolism Pharmacology. Drug treatments tamoxifen Tamoxifen - therapeutic use Transplantation, Heterologous Tumor Cells, Cultured
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