Kinetic Study of DNA Condensation by Cationic Peptides Used in Nonviral Gene Therapy:  Analogy of DNA Condensation to Protein Folding

Synthetic nonviral vector systems are attractive because of their apparent simplicity of preparation and use. However, there are many barriers to success at the moment, including the formulation of uniform and reproducible particles of transfection competent, condensed nucleic acids such as plasmid...

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Veröffentlicht in:	Biochemistry (Easton) 2003-09, Vol.42 (35), p.10343-10347
Hauptverfasser:	Tecle, Miriam, Preuss, Monika, Miller, Andrew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cations - metabolism DNA - chemistry DNA - metabolism Ethidium - metabolism Fluorescent Dyes - metabolism Genetic Therapy - methods Macromolecular Substances Molecular Sequence Data Peptides - metabolism Protein Folding
Online-Zugang:	Volltext
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