Angiogenesis in glioma: molecular mechanisms and roadblocks to translation

Gliomas are characterized by very high levels of neo-vascularization holding out the hope that therapies aimed at angiogenesis will have a significant impact on this intractable family of tumors. Intense research into the molecular mechanisms that drive the formation of new blood vessels in response...

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Veröffentlicht in:	The cancer journal (Sudbury, Mass.) Mass.), 2003-05, Vol.9 (3), p.205-213
Hauptverfasser:	Bögler, Oliver, Mikkelsen, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Drug Delivery Systems Glioma - drug therapy Glioma - metabolism Humans Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - prevention & control Signal Transduction - drug effects
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