Expression of Smad4 and Smad7 in human thyroid follicular carcinoma cell lines

Smad proteins have been shown tomediate the signal transduction pathway downstream of the transforming growth factor beta (TGFbeta). TGFbeta induces the phosphorylation of Smad2 and Smad3 which associate with Smad4 and translocate to the nucleus where they regulate gene transcription; besides these...

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Veröffentlicht in:	Journal of endocrinological investigation 2003-06, Vol.26 (6), p.516-521
Hauptverfasser:	CERUTTI, J. M, EBINA, K. N, MATSUO, S. E, MARTINS, L, MACIEL, R. M. B, KIMURA, E. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Follicular - metabolism Biological and medical sciences Carcinoma - metabolism Carcinoma, Papillary - metabolism Cell Line, Tumor DNA-Binding Proteins - metabolism Endocrinopathies Humans Immunohistochemistry Malignant tumors Medical sciences Phosphoproteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Smad4 Protein Smad5 Protein Thyroid Neoplasms - metabolism Thyroid. Thyroid axis (diseases) Trans-Activators - metabolism
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