The Amyloid β Peptide (Aβ1 - 40) Is Thermodynamically Soluble at Physiological Concentrations

Precipitation of the 39−43-residue amyloid β peptide (Aβ) is a crucial factor in Alzheimer's disease (AD). In normal as well as in AD-afflicted brain, the Aβ concentration is estimated to be a few nanomolar. Here we show that Aβ1 - 40 precipitates in vitro only if the dissolved concentration is...

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Veröffentlicht in:	Biochemistry (Easton) 2003-09, Vol.42 (35), p.10506-10513
Hauptverfasser:	Sengupta, Parijat, Garai, K, Sahoo, B, Shi, Yuan, Callaway, David J. E, Maiti, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism Animals Chemical Precipitation Humans Mathematics Peptide Fragments - chemistry Peptide Fragments - metabolism Solubility Spectrometry, Fluorescence Thermodynamics Tyrosine - metabolism
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