Effect of chronic vitamin D deficiency on chick heart mitochondrial oxidative phosphorylation
Chicks were raised for 3 to 4 weeks either on a normal (vitamin D supplemented) or a rachitogenic diet. The Ca 2+ content of the serum, heart tissue and heart mitochondria was significantly decreased in chicks raised on a rachitogenic diet. In mitochondria isolated from calcium deficient hearts, the...
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| Veröffentlicht in: | Journal of molecular and cellular cardiology 1981-02, Vol.13 (2), p.171-183 |
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| container_title | Journal of molecular and cellular cardiology |
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| creator | Mukherjee, Amal Zetwekh, Joseph E. Nicar, Michael J. McCoy, Kenneth Buja, L.Maximilian |
| description | Chicks were raised for 3 to 4 weeks either on a normal (vitamin D supplemented) or a rachitogenic diet. The Ca
2+ content of the serum, heart tissue and heart mitochondria was significantly decreased in chicks raised on a rachitogenic diet. In mitochondria isolated from calcium deficient hearts, the rate of ADP induced state 3 respiration and 2,4-DNP uncoupled respiration were significantly decreased. Furthermore, the ATP content of heart tissue was significantly decreased in calcium deficient hearts. These data suggest that an overall deficiency in energy production via oxidative phosphorylation exists in chronic calcium deficiency secondary to vitamin D deficiency. When vitamin D deficient chicks were orally dosed with vitamin D
3, serum calcium level and state 3 respiration rate returned to normal indicating that the above changes are reversible. Although previous studies have indicated that excess Ca
2+ has deleterious effects on mitochondria, the results of the present study suggest that optimal mitochondrial function is dependent upon vitamin D dependent phenomena, including maintenance of calcium concentration within a relatively narrow range. |
| doi_str_mv | 10.1016/0022-2828(81)90214-5 |
| format | Article |
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3, serum calcium level and state 3 respiration rate returned to normal indicating that the above changes are reversible. Although previous studies have indicated that excess Ca
2+ has deleterious effects on mitochondria, the results of the present study suggest that optimal mitochondrial function is dependent upon vitamin D dependent phenomena, including maintenance of calcium concentration within a relatively narrow range.</description><identifier>ISSN: 0022-2828</identifier><identifier>EISSN: 1095-8584</identifier><identifier>DOI: 10.1016/0022-2828(81)90214-5</identifier><identifier>PMID: 6115063</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adenosine Triphosphate - metabolism ; Animals ; Calcium - analysis ; Calcium - blood ; Calcium deficiency ; Chickens ; Cytochrome c Group - metabolism ; Glutamates - metabolism ; Glutamic Acid ; Heart mitochondria ; Malates - metabolism ; Male ; Mitochondria, Heart - metabolism ; Mitochondria, Heart - ultrastructure ; Myocardium - pathology ; Oxidative Phosphorylation ; Oxygen Consumption ; Vitamin D deficiency ; Vitamin D Deficiency - metabolism</subject><ispartof>Journal of molecular and cellular cardiology, 1981-02, Vol.13 (2), p.171-183</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-1d7b4d4b0caab53aa4d14d36c334a1131674d8a4aebf9f5be8966cec0adaef993</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-2828(81)90214-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6115063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mukherjee, Amal</creatorcontrib><creatorcontrib>Zetwekh, Joseph E.</creatorcontrib><creatorcontrib>Nicar, Michael J.</creatorcontrib><creatorcontrib>McCoy, Kenneth</creatorcontrib><creatorcontrib>Buja, L.Maximilian</creatorcontrib><title>Effect of chronic vitamin D deficiency on chick heart mitochondrial oxidative phosphorylation</title><title>Journal of molecular and cellular cardiology</title><addtitle>J Mol Cell Cardiol</addtitle><description>Chicks were raised for 3 to 4 weeks either on a normal (vitamin D supplemented) or a rachitogenic diet. The Ca
2+ content of the serum, heart tissue and heart mitochondria was significantly decreased in chicks raised on a rachitogenic diet. In mitochondria isolated from calcium deficient hearts, the rate of ADP induced state 3 respiration and 2,4-DNP uncoupled respiration were significantly decreased. Furthermore, the ATP content of heart tissue was significantly decreased in calcium deficient hearts. These data suggest that an overall deficiency in energy production via oxidative phosphorylation exists in chronic calcium deficiency secondary to vitamin D deficiency. When vitamin D deficient chicks were orally dosed with vitamin D
3, serum calcium level and state 3 respiration rate returned to normal indicating that the above changes are reversible. Although previous studies have indicated that excess Ca
2+ has deleterious effects on mitochondria, the results of the present study suggest that optimal mitochondrial function is dependent upon vitamin D dependent phenomena, including maintenance of calcium concentration within a relatively narrow range.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Animals</subject><subject>Calcium - analysis</subject><subject>Calcium - blood</subject><subject>Calcium deficiency</subject><subject>Chickens</subject><subject>Cytochrome c Group - metabolism</subject><subject>Glutamates - metabolism</subject><subject>Glutamic Acid</subject><subject>Heart mitochondria</subject><subject>Malates - metabolism</subject><subject>Male</subject><subject>Mitochondria, Heart - metabolism</subject><subject>Mitochondria, Heart - ultrastructure</subject><subject>Myocardium - pathology</subject><subject>Oxidative Phosphorylation</subject><subject>Oxygen Consumption</subject><subject>Vitamin D deficiency</subject><subject>Vitamin D Deficiency - metabolism</subject><issn>0022-2828</issn><issn>1095-8584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gUJOoofVZJPsx0WQWj-g4EWPErLJhI3ubmqyLfbfu7WlRw_DMLzvO8M8CJ1TckMJzW4JSdMkLdLiqqDXJUkpT8QBGlNSiqQQBT9E473lGJ3E-EkIKTljIzTKKBUkY2P0MbMWdI-9xboOvnMar1yvWtfhB2zAOu2g02vsu0F3-gvXoEKPW9d7XfvOBKca7H-cUb1bAV7UPg4V1s0w--4UHVnVRDjb9Ql6f5y9TZ-T-evTy_R-nmgm8j6hJq-44RXRSlWCKcUN5YZlmjGuKGU0y7kpFFdQ2dKKCooyyzRooowCW5Zsgi63exfBfy8h9rJ1UUPTqA78MsqcZZQIxgYj3xp18DEGsHIRXKvCWlIiN1TlBpncIJMFlX9UpRhiF7v9y6oFsw_tMA763VaH4cmVgyDjHzcwLgx0pfHu_wO_mlqIgg</recordid><startdate>198102</startdate><enddate>198102</enddate><creator>Mukherjee, Amal</creator><creator>Zetwekh, Joseph E.</creator><creator>Nicar, Michael J.</creator><creator>McCoy, Kenneth</creator><creator>Buja, L.Maximilian</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198102</creationdate><title>Effect of chronic vitamin D deficiency on chick heart mitochondrial oxidative phosphorylation</title><author>Mukherjee, Amal ; Zetwekh, Joseph E. ; Nicar, Michael J. ; McCoy, Kenneth ; Buja, L.Maximilian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-1d7b4d4b0caab53aa4d14d36c334a1131674d8a4aebf9f5be8966cec0adaef993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Animals</topic><topic>Calcium - analysis</topic><topic>Calcium - blood</topic><topic>Calcium deficiency</topic><topic>Chickens</topic><topic>Cytochrome c Group - metabolism</topic><topic>Glutamates - metabolism</topic><topic>Glutamic Acid</topic><topic>Heart mitochondria</topic><topic>Malates - metabolism</topic><topic>Male</topic><topic>Mitochondria, Heart - metabolism</topic><topic>Mitochondria, Heart - ultrastructure</topic><topic>Myocardium - pathology</topic><topic>Oxidative Phosphorylation</topic><topic>Oxygen Consumption</topic><topic>Vitamin D deficiency</topic><topic>Vitamin D Deficiency - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mukherjee, Amal</creatorcontrib><creatorcontrib>Zetwekh, Joseph E.</creatorcontrib><creatorcontrib>Nicar, Michael J.</creatorcontrib><creatorcontrib>McCoy, Kenneth</creatorcontrib><creatorcontrib>Buja, L.Maximilian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular and cellular cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mukherjee, Amal</au><au>Zetwekh, Joseph E.</au><au>Nicar, Michael J.</au><au>McCoy, Kenneth</au><au>Buja, L.Maximilian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of chronic vitamin D deficiency on chick heart mitochondrial oxidative phosphorylation</atitle><jtitle>Journal of molecular and cellular cardiology</jtitle><addtitle>J Mol Cell Cardiol</addtitle><date>1981-02</date><risdate>1981</risdate><volume>13</volume><issue>2</issue><spage>171</spage><epage>183</epage><pages>171-183</pages><issn>0022-2828</issn><eissn>1095-8584</eissn><abstract>Chicks were raised for 3 to 4 weeks either on a normal (vitamin D supplemented) or a rachitogenic diet. The Ca
2+ content of the serum, heart tissue and heart mitochondria was significantly decreased in chicks raised on a rachitogenic diet. In mitochondria isolated from calcium deficient hearts, the rate of ADP induced state 3 respiration and 2,4-DNP uncoupled respiration were significantly decreased. Furthermore, the ATP content of heart tissue was significantly decreased in calcium deficient hearts. These data suggest that an overall deficiency in energy production via oxidative phosphorylation exists in chronic calcium deficiency secondary to vitamin D deficiency. When vitamin D deficient chicks were orally dosed with vitamin D
3, serum calcium level and state 3 respiration rate returned to normal indicating that the above changes are reversible. Although previous studies have indicated that excess Ca
2+ has deleterious effects on mitochondria, the results of the present study suggest that optimal mitochondrial function is dependent upon vitamin D dependent phenomena, including maintenance of calcium concentration within a relatively narrow range.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>6115063</pmid><doi>10.1016/0022-2828(81)90214-5</doi><tpages>13</tpages></addata></record> |
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| ispartof | Journal of molecular and cellular cardiology, 1981-02, Vol.13 (2), p.171-183 |
| issn | 0022-2828 1095-8584 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenosine Triphosphate - metabolism Animals Calcium - analysis Calcium - blood Calcium deficiency Chickens Cytochrome c Group - metabolism Glutamates - metabolism Glutamic Acid Heart mitochondria Malates - metabolism Male Mitochondria, Heart - metabolism Mitochondria, Heart - ultrastructure Myocardium - pathology Oxidative Phosphorylation Oxygen Consumption Vitamin D deficiency Vitamin D Deficiency - metabolism |
| title | Effect of chronic vitamin D deficiency on chick heart mitochondrial oxidative phosphorylation |
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