Trophoblastic Pulmonary Embolism

Trophoblastic embolism is subclinical in normal pregnancy, pronounced in eclampsia, and massive in hydatidiform mole. Self-limited acute respiratory distress arises in 3% to 10% of molar pregnancies at the time of uterine evacuation. Infrequently death occurs; the principal findings are trophoblasti...

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Veröffentlicht in:Southern medical journal (Birmingham, Ala.) Ala.), 1981-08, Vol.74 (8), p.916-919
Hauptverfasser: SMITH, J CHANDLER, ALSULEIMAN, SULEIMAN A, BISHOP, HENRY, KASSAR, NAIM S, JONAS, HARRY S
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container_end_page 919
container_issue 8
container_start_page 916
container_title Southern medical journal (Birmingham, Ala.)
container_volume 74
creator SMITH, J CHANDLER
ALSULEIMAN, SULEIMAN A
BISHOP, HENRY
KASSAR, NAIM S
JONAS, HARRY S
description Trophoblastic embolism is subclinical in normal pregnancy, pronounced in eclampsia, and massive in hydatidiform mole. Self-limited acute respiratory distress arises in 3% to 10% of molar pregnancies at the time of uterine evacuation. Infrequently death occurs; the principal findings are trophoblastic emboli in the pulmonary arterioles, edema of the lungs, and dilatation of the right side of the heart. Hyperthroidism may develop, and fibrin may line the alveolar walls. Pathogenetic mechanisms include heart failure, hyperthyroidism, dilutional anemia, and pulmonary arteriolar blockage. Infusions of fluid and whole blood tend to cause pulmonary overload, which may precipitate right-sided heart failure. Preferred therapy consists of diuresis and ventilatory support, especially with oxygen under positive end-expiratory pressure.
doi_str_mv 10.1097/00007611-198108000-00006
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Self-limited acute respiratory distress arises in 3% to 10% of molar pregnancies at the time of uterine evacuation. Infrequently death occurs; the principal findings are trophoblastic emboli in the pulmonary arterioles, edema of the lungs, and dilatation of the right side of the heart. Hyperthroidism may develop, and fibrin may line the alveolar walls. Pathogenetic mechanisms include heart failure, hyperthyroidism, dilutional anemia, and pulmonary arteriolar blockage. Infusions of fluid and whole blood tend to cause pulmonary overload, which may precipitate right-sided heart failure. 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ispartof Southern medical journal (Birmingham, Ala.), 1981-08, Vol.74 (8), p.916-919
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source MEDLINE; Journals@Ovid Ovid Autoload
subjects Adult
Diuresis
Female
Humans
Intermittent Positive-Pressure Ventilation
Pregnancy
Pulmonary Embolism - etiology
Pulmonary Embolism - therapy
Trophoblastic Neoplasms - complications
Trophoblastic Neoplasms - therapy
Uterine Neoplasms - complications
Uterine Neoplasms - therapy
title Trophoblastic Pulmonary Embolism
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