The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial
Summary Background Recent studies of antidandruff shampoos or tonics containing antifungal or antibacterial agents produced effects suggestive of a potential hair growth benefit. Objectives The purpose of this 6‐month, 200‐patient, randomized, investigator‐blinded, parallel‐group clinical study wa...
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| Veröffentlicht in: | British journal of dermatology (1951) 2003-08, Vol.149 (2), p.354-362 |
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| container_title | British journal of dermatology (1951) |
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| creator | Berger, R.S. Fu, J.L. Smiles, K.A. Turner, C.B. Schnell, B.M. Werchowski, K.M. Lammers, K.M. |
| description | Summary
Background Recent studies of antidandruff shampoos or tonics containing antifungal or antibacterial agents produced effects suggestive of a potential hair growth benefit.
Objectives The purpose of this 6‐month, 200‐patient, randomized, investigator‐blinded, parallel‐group clinical study was to assess the hair growth benefits of a 1% pyrithione zinc shampoo. The efficacy of a 1% pyrithione zinc shampoo (used daily), was compared with that of a 5% minoxidil topical solution (applied twice daily), a placebo shampoo and a combination of the 1% pyrithione zinc shampoo and the 5% minoxidil topical solution.
Methods Two hundred healthy men between the ages of 18 and 49 years (inclusive) exhibiting Hamilton–Norwood type III vertex or type IV baldness were enrolled. Total hair counts, the primary efficacy measure, were obtained using fibre‐optic microscopy and a computer‐assisted, manual hair count method. Secondary measures of efficacy included assessments of hair diameter, as well as patient and investigator global assessments of improvement in hair growth. These were based on photographs of the scalp using both midline and vertex views.
Results Hair count results showed a significant (P |
| doi_str_mv | 10.1046/j.1365-2133.2003.05435.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73609621</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>532724561</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5265-e343e2ba25e64e3bfbc33e78c9ce0dd4c6f6eab0aff72c4f0662d47998734423</originalsourceid><addsrcrecordid>eNqNkcFu1DAQhi0EosvCKyALqZxIcDyJkyBxgNIWUAUcVuzRcpyx1ksSL3Yidvv0ON1VK3Hi5JH9faPxP4TQjKUZy8XbbZqBKBKeAaScMUhZkUOR7h-Rxf3DY7JgjJUJqwWckWchbBnLgBXsKTnLeA2c57Ag02qDFI1BPQbqDO3t4Pa2td0bmp3T3cHbcWPdgPTWDpqqoaWKatc3dlBjvJ-Vxo0bGsuNsp62OAQ7Ht5FzEfa9fYW22gMo3ddF8vRW9U9J0-M6gK-OJ1Lsrq6XF18Tm6-X3-5-HCT6ILHbyDkgLxRvECRIzSm0QBYVrrWyNo218IIVA1TxpRc54YJwdu8rOuqhDznsCSvj2133v2eMIyyt0Fj16kB3RRkCSKmE8Naklf_gFs3-SGOJvkcYlXzKkLVEdLeheDRyJ23vfIHmTE5r0Vu5Zy-nNOfPZB3a5H7qL489Z-aHtsH8bSHCJyfABW06kzMTtvwwBVMlAUrIvf-yP2xHR7-ewD58eunuYp-cvRtGHF_7yv_S4oSykKuv13L-uoH1OtyLX_CX3iLt3M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>200078928</pqid></control><display><type>article</type><title>The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial</title><source>MEDLINE</source><source>Oxford University Press Journals Current</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Berger, R.S. ; Fu, J.L. ; Smiles, K.A. ; Turner, C.B. ; Schnell, B.M. ; Werchowski, K.M. ; Lammers, K.M.</creator><creatorcontrib>Berger, R.S. ; Fu, J.L. ; Smiles, K.A. ; Turner, C.B. ; Schnell, B.M. ; Werchowski, K.M. ; Lammers, K.M.</creatorcontrib><description>Summary
Background Recent studies of antidandruff shampoos or tonics containing antifungal or antibacterial agents produced effects suggestive of a potential hair growth benefit.
Objectives The purpose of this 6‐month, 200‐patient, randomized, investigator‐blinded, parallel‐group clinical study was to assess the hair growth benefits of a 1% pyrithione zinc shampoo. The efficacy of a 1% pyrithione zinc shampoo (used daily), was compared with that of a 5% minoxidil topical solution (applied twice daily), a placebo shampoo and a combination of the 1% pyrithione zinc shampoo and the 5% minoxidil topical solution.
Methods Two hundred healthy men between the ages of 18 and 49 years (inclusive) exhibiting Hamilton–Norwood type III vertex or type IV baldness were enrolled. Total hair counts, the primary efficacy measure, were obtained using fibre‐optic microscopy and a computer‐assisted, manual hair count method. Secondary measures of efficacy included assessments of hair diameter, as well as patient and investigator global assessments of improvement in hair growth. These were based on photographs of the scalp using both midline and vertex views.
Results Hair count results showed a significant (P < 0·05) net increase in total visible hair counts for the 1% pyrithione zinc shampoo, the 5% minoxidil topical solution, and the combination treatment groups relative to the placebo shampoo after 9 weeks of treatment. The relative increase in hair count for the 1% pyrithione zinc shampoo was slightly less than half that for the minoxidil topical solution and was essentially maintained throughout the 26‐week treatment period. No advantage was seen in using both the 5% minoxidil topical solution and the 1% pyrithione zinc shampoo. A small increase in hair diameter was observed for the minoxidil‐containing treatment groups at week 17. Assessments of global improvements by the patients and investigator generally showed the benefit of 5% minoxidil. The benefit of the 1% pyrithione zinc shampoo used alone tended (P < 0·1) to be apparent only to the investigator.
Conclusions Hair count results show a modest and sustained improvement in hair growth with daily use of a 1% pyrithione zinc shampoo over a 26‐week treatment period.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1046/j.1365-2133.2003.05435.x</identifier><identifier>PMID: 12932243</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Adult ; Alopecia - drug therapy ; Alopecia - pathology ; Alopecia - physiopathology ; Analysis of Variance ; Biological and medical sciences ; Dermatology ; Drug Therapy, Combination ; Fiber Optic Technology ; Hair - drug effects ; Hair - growth & development ; Hair - pathology ; Hair and nails disorders ; Hair Preparations ; Humans ; Male ; male pattern baldness ; Medical sciences ; microscopy ; Middle Aged ; minoxidil ; Minoxidil - therapeutic use ; Organometallic Compounds - therapeutic use ; Patient Satisfaction ; Pharmacology. Drug treatments ; Photography ; Pyridines - therapeutic use ; pyrithione zinc ; randomized controlled trial ; Single-Blind Method ; Skin, nail, hair, dermoskeleton ; Treatment Outcome</subject><ispartof>British journal of dermatology (1951), 2003-08, Vol.149 (2), p.354-362</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Aug 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5265-e343e2ba25e64e3bfbc33e78c9ce0dd4c6f6eab0aff72c4f0662d47998734423</citedby><cites>FETCH-LOGICAL-c5265-e343e2ba25e64e3bfbc33e78c9ce0dd4c6f6eab0aff72c4f0662d47998734423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2133.2003.05435.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2133.2003.05435.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15067505$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12932243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berger, R.S.</creatorcontrib><creatorcontrib>Fu, J.L.</creatorcontrib><creatorcontrib>Smiles, K.A.</creatorcontrib><creatorcontrib>Turner, C.B.</creatorcontrib><creatorcontrib>Schnell, B.M.</creatorcontrib><creatorcontrib>Werchowski, K.M.</creatorcontrib><creatorcontrib>Lammers, K.M.</creatorcontrib><title>The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background Recent studies of antidandruff shampoos or tonics containing antifungal or antibacterial agents produced effects suggestive of a potential hair growth benefit.
Objectives The purpose of this 6‐month, 200‐patient, randomized, investigator‐blinded, parallel‐group clinical study was to assess the hair growth benefits of a 1% pyrithione zinc shampoo. The efficacy of a 1% pyrithione zinc shampoo (used daily), was compared with that of a 5% minoxidil topical solution (applied twice daily), a placebo shampoo and a combination of the 1% pyrithione zinc shampoo and the 5% minoxidil topical solution.
Methods Two hundred healthy men between the ages of 18 and 49 years (inclusive) exhibiting Hamilton–Norwood type III vertex or type IV baldness were enrolled. Total hair counts, the primary efficacy measure, were obtained using fibre‐optic microscopy and a computer‐assisted, manual hair count method. Secondary measures of efficacy included assessments of hair diameter, as well as patient and investigator global assessments of improvement in hair growth. These were based on photographs of the scalp using both midline and vertex views.
Results Hair count results showed a significant (P < 0·05) net increase in total visible hair counts for the 1% pyrithione zinc shampoo, the 5% minoxidil topical solution, and the combination treatment groups relative to the placebo shampoo after 9 weeks of treatment. The relative increase in hair count for the 1% pyrithione zinc shampoo was slightly less than half that for the minoxidil topical solution and was essentially maintained throughout the 26‐week treatment period. No advantage was seen in using both the 5% minoxidil topical solution and the 1% pyrithione zinc shampoo. A small increase in hair diameter was observed for the minoxidil‐containing treatment groups at week 17. Assessments of global improvements by the patients and investigator generally showed the benefit of 5% minoxidil. The benefit of the 1% pyrithione zinc shampoo used alone tended (P < 0·1) to be apparent only to the investigator.
Conclusions Hair count results show a modest and sustained improvement in hair growth with daily use of a 1% pyrithione zinc shampoo over a 26‐week treatment period.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alopecia - drug therapy</subject><subject>Alopecia - pathology</subject><subject>Alopecia - physiopathology</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Drug Therapy, Combination</subject><subject>Fiber Optic Technology</subject><subject>Hair - drug effects</subject><subject>Hair - growth & development</subject><subject>Hair - pathology</subject><subject>Hair and nails disorders</subject><subject>Hair Preparations</subject><subject>Humans</subject><subject>Male</subject><subject>male pattern baldness</subject><subject>Medical sciences</subject><subject>microscopy</subject><subject>Middle Aged</subject><subject>minoxidil</subject><subject>Minoxidil - therapeutic use</subject><subject>Organometallic Compounds - therapeutic use</subject><subject>Patient Satisfaction</subject><subject>Pharmacology. Drug treatments</subject><subject>Photography</subject><subject>Pyridines - therapeutic use</subject><subject>pyrithione zinc</subject><subject>randomized controlled trial</subject><subject>Single-Blind Method</subject><subject>Skin, nail, hair, dermoskeleton</subject><subject>Treatment Outcome</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhi0EosvCKyALqZxIcDyJkyBxgNIWUAUcVuzRcpyx1ksSL3Yidvv0ON1VK3Hi5JH9faPxP4TQjKUZy8XbbZqBKBKeAaScMUhZkUOR7h-Rxf3DY7JgjJUJqwWckWchbBnLgBXsKTnLeA2c57Ag02qDFI1BPQbqDO3t4Pa2td0bmp3T3cHbcWPdgPTWDpqqoaWKatc3dlBjvJ-Vxo0bGsuNsp62OAQ7Ht5FzEfa9fYW22gMo3ddF8vRW9U9J0-M6gK-OJ1Lsrq6XF18Tm6-X3-5-HCT6ILHbyDkgLxRvECRIzSm0QBYVrrWyNo218IIVA1TxpRc54YJwdu8rOuqhDznsCSvj2133v2eMIyyt0Fj16kB3RRkCSKmE8Naklf_gFs3-SGOJvkcYlXzKkLVEdLeheDRyJ23vfIHmTE5r0Vu5Zy-nNOfPZB3a5H7qL489Z-aHtsH8bSHCJyfABW06kzMTtvwwBVMlAUrIvf-yP2xHR7-ewD58eunuYp-cvRtGHF_7yv_S4oSykKuv13L-uoH1OtyLX_CX3iLt3M</recordid><startdate>200308</startdate><enddate>200308</enddate><creator>Berger, R.S.</creator><creator>Fu, J.L.</creator><creator>Smiles, K.A.</creator><creator>Turner, C.B.</creator><creator>Schnell, B.M.</creator><creator>Werchowski, K.M.</creator><creator>Lammers, K.M.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200308</creationdate><title>The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial</title><author>Berger, R.S. ; Fu, J.L. ; Smiles, K.A. ; Turner, C.B. ; Schnell, B.M. ; Werchowski, K.M. ; Lammers, K.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5265-e343e2ba25e64e3bfbc33e78c9ce0dd4c6f6eab0aff72c4f0662d47998734423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alopecia - drug therapy</topic><topic>Alopecia - pathology</topic><topic>Alopecia - physiopathology</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Drug Therapy, Combination</topic><topic>Fiber Optic Technology</topic><topic>Hair - drug effects</topic><topic>Hair - growth & development</topic><topic>Hair - pathology</topic><topic>Hair and nails disorders</topic><topic>Hair Preparations</topic><topic>Humans</topic><topic>Male</topic><topic>male pattern baldness</topic><topic>Medical sciences</topic><topic>microscopy</topic><topic>Middle Aged</topic><topic>minoxidil</topic><topic>Minoxidil - therapeutic use</topic><topic>Organometallic Compounds - therapeutic use</topic><topic>Patient Satisfaction</topic><topic>Pharmacology. Drug treatments</topic><topic>Photography</topic><topic>Pyridines - therapeutic use</topic><topic>pyrithione zinc</topic><topic>randomized controlled trial</topic><topic>Single-Blind Method</topic><topic>Skin, nail, hair, dermoskeleton</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berger, R.S.</creatorcontrib><creatorcontrib>Fu, J.L.</creatorcontrib><creatorcontrib>Smiles, K.A.</creatorcontrib><creatorcontrib>Turner, C.B.</creatorcontrib><creatorcontrib>Schnell, B.M.</creatorcontrib><creatorcontrib>Werchowski, K.M.</creatorcontrib><creatorcontrib>Lammers, K.M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berger, R.S.</au><au>Fu, J.L.</au><au>Smiles, K.A.</au><au>Turner, C.B.</au><au>Schnell, B.M.</au><au>Werchowski, K.M.</au><au>Lammers, K.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2003-08</date><risdate>2003</risdate><volume>149</volume><issue>2</issue><spage>354</spage><epage>362</epage><pages>354-362</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary
Background Recent studies of antidandruff shampoos or tonics containing antifungal or antibacterial agents produced effects suggestive of a potential hair growth benefit.
Objectives The purpose of this 6‐month, 200‐patient, randomized, investigator‐blinded, parallel‐group clinical study was to assess the hair growth benefits of a 1% pyrithione zinc shampoo. The efficacy of a 1% pyrithione zinc shampoo (used daily), was compared with that of a 5% minoxidil topical solution (applied twice daily), a placebo shampoo and a combination of the 1% pyrithione zinc shampoo and the 5% minoxidil topical solution.
Methods Two hundred healthy men between the ages of 18 and 49 years (inclusive) exhibiting Hamilton–Norwood type III vertex or type IV baldness were enrolled. Total hair counts, the primary efficacy measure, were obtained using fibre‐optic microscopy and a computer‐assisted, manual hair count method. Secondary measures of efficacy included assessments of hair diameter, as well as patient and investigator global assessments of improvement in hair growth. These were based on photographs of the scalp using both midline and vertex views.
Results Hair count results showed a significant (P < 0·05) net increase in total visible hair counts for the 1% pyrithione zinc shampoo, the 5% minoxidil topical solution, and the combination treatment groups relative to the placebo shampoo after 9 weeks of treatment. The relative increase in hair count for the 1% pyrithione zinc shampoo was slightly less than half that for the minoxidil topical solution and was essentially maintained throughout the 26‐week treatment period. No advantage was seen in using both the 5% minoxidil topical solution and the 1% pyrithione zinc shampoo. A small increase in hair diameter was observed for the minoxidil‐containing treatment groups at week 17. Assessments of global improvements by the patients and investigator generally showed the benefit of 5% minoxidil. The benefit of the 1% pyrithione zinc shampoo used alone tended (P < 0·1) to be apparent only to the investigator.
Conclusions Hair count results show a modest and sustained improvement in hair growth with daily use of a 1% pyrithione zinc shampoo over a 26‐week treatment period.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>12932243</pmid><doi>10.1046/j.1365-2133.2003.05435.x</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals Current; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Alopecia - drug therapy Alopecia - pathology Alopecia - physiopathology Analysis of Variance Biological and medical sciences Dermatology Drug Therapy, Combination Fiber Optic Technology Hair - drug effects Hair - growth & development Hair - pathology Hair and nails disorders Hair Preparations Humans Male male pattern baldness Medical sciences microscopy Middle Aged minoxidil Minoxidil - therapeutic use Organometallic Compounds - therapeutic use Patient Satisfaction Pharmacology. Drug treatments Photography Pyridines - therapeutic use pyrithione zinc randomized controlled trial Single-Blind Method Skin, nail, hair, dermoskeleton Treatment Outcome |
| title | The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial |
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