L-PhGPx expression can be suppressed by antisense oligodeoxynucleotides

Phospholipid hydroperoxide glutathione peroxidase (PhGPx) directly reduces hydroperoxides of phospholipid and cholesterol to their corresponding alcohols. There are two forms of PhGPx: L-PhGPx localizes in mitochondria and S-PhGPx in cytosol. Antisense oligodeoxynucleotides can inhibit specific prot...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2003-09, Vol.417 (2), p.212-218
Hauptverfasser:	Zhao, Lingjie, Wang, Hong P., Zhang, Hannah J., Weydert, Christine J., Domann, Frederick E., Oberley, Larry W., Buettner, Garry R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisense oligodeoxynucleotides Base Sequence Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Membrane - drug effects Cell Membrane - metabolism Free radicals Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Glutathione Peroxidase - biosynthesis Glutathione Peroxidase - genetics Humans Lipid hydroperoxides Lipid peroxidation Molecular Sequence Data Oligodeoxyribonucleotides, Antisense - genetics Oligodeoxyribonucleotides, Antisense - pharmacology Photosensitization Transfection - methods Tumor Cells, Cultured
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