Pathogenicity of Toxoplasma gondii through B-2 Cell-Mediated Downregulation of Host Defense Responses

IFN‐γ is the primary mediator of anti‐parasite effector mechanisms against Toxoplasma gondii. After intraperitoneal infection with the Fukaya strain of T. gondii, unirradiated IFN‐γ knock‐out (GKO) mice transferred with wild type (WT) CD8+ effector T cells from infected mice failed to induce the pro...

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Veröffentlicht in:	Microbiology and immunology 2003-01, Vol.47 (7), p.533-542
Hauptverfasser:	Mun, Hye-Seong, Aosai, Fumie, Chen, Mei, Piao, Lian-Xun, Norose, Kazumi, Iwakura, Yoichiro, Yano, Akihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals B-lymphocytes B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism cytokine Cytokines - metabolism DNA-Binding Proteins - metabolism Down-Regulation Immunity - radiation effects Interferon-gamma - biosynthesis Mice Mice, Inbred BALB C Mice, Knockout nitric oxide Nitric Oxide - metabolism STAT1 Transcription Factor T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - transplantation Toxoplasma - pathogenicity toxoplasma gondii Toxoplasmosis, Animal - immunology Toxoplasmosis, Animal - physiopathology Trans-Activators - metabolism X-Rays
Online-Zugang:	Volltext
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