Arraying autoimmunity treatment
Protein arrays offer great promise for profiling changes in protein levels and composition to develop new biomarkers for early diagnosis of disease and to design new treatments. But can the mass of data collected in such experiments be applied to practical, clinical use? In an exciting advance, Robi...
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| Veröffentlicht in: | Nature biotechnology 2003-09, Vol.21 (9), p.1017-1019 |
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| creator | Sercarz, Eli E |
| description | Protein arrays offer great promise for profiling changes in protein levels and composition to develop new biomarkers for early diagnosis of disease and to design new treatments. But can the mass of data collected in such experiments be applied to practical, clinical use? In an exciting advance, Robinson et al. report in this issue the use of protein microarrays to predict and design a multicomponent protective DNA vaccine against an autoimmune disease. By revealing the spectrum of antibodies raised in individual mice during an autoimmune disease, microarray analysis is exploited to predict the relevant autoantigen cDNAs for inclusion in DNA vaccines. The authors demonstrate that superior protection is afforded by vaccines which raise the largest diversity of antibodies. |
| doi_str_mv | 10.1038/nbt0903-1017 |
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| ispartof | Nature biotechnology, 2003-09, Vol.21 (9), p.1017-1019 |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Agriculture Animals Bioinformatics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Drug Tolerance Encephalomyelitis, Autoimmune, Experimental - diagnosis Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - immunology Immunoassay - methods Life Sciences Mice Multiple Sclerosis - diagnosis Multiple Sclerosis - drug therapy Multiple Sclerosis - immunology Myelin Sheath - immunology news-and-views Protein Array Analysis - methods Protein Interaction Mapping - methods Treatment Outcome Vaccines, DNA - immunology Vaccines, DNA - therapeutic use |
| title | Arraying autoimmunity treatment |
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