DNA damage checkpoint control in cells exposed to ionizing radiation

Damage induced in the DNA after exposure of cells to ionizing radiation activates checkpoint pathways that inhibit progression of cells through the G1 and G2 phases and induce a transient delay in the progression through S phase. Checkpoints together with repair and apoptosis are integrated in a cir...

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Veröffentlicht in:	Oncogene 2003-09, Vol.22 (37), p.5834-5847
Hauptverfasser:	Iliakis, George, Wang, Ya, Guan, Jun, Wang, Huichen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cancer Cell Biology Cell cycle Cell Cycle - radiation effects CHK1 protein Cyclin-dependent kinases Deoxyribonucleic acid DNA DNA damage DNA Damage - radiation effects DNA Repair Genes, cdc - radiation effects Genomes Human Genetics Humans Internal Medicine Ionizing radiation Kinases Medicine Medicine & Public Health Neoplasms - etiology Neoplasms - genetics Neoplasms - metabolism Oncology p53 Protein Proteins Radiation review S phase Space life sciences Surveillance
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