Balance of Pro- and Anti-Inflammatory Cytokines in Liver Surgery
Inflammatory response in surgery is associated with the release of cytokines. Many cytokines are produced by macrophages; therefore surgical injuries to the liver may have great influence on the release of cytokines. Ischemia creates tissue injury and may contribute to the cytokine release. A balanc...
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| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2003-07, Vol.41 (7), p.899-903 |
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| container_title | Clinical chemistry and laboratory medicine |
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| creator | Jerin, Aleš Požar-Lukanovič, Neva Sojar, Valentin Stanisavljevič, Dragoje Paver-Eržen, Vesna Osredkar, Joško |
| description | Inflammatory response in surgery is associated with the release of cytokines. Many cytokines are produced by macrophages; therefore surgical injuries to the liver may have great influence on the release of cytokines. Ischemia creates tissue injury and may contribute to the cytokine release. A balanced ratio of pro- and anti-inflammatory cytokines is important for appropriate immune response; excessive inflammation or hypo-responsiveness can lead to post-operative complications. To determine the magnitude of the cytokine response caused by liver surgery and to evaluate the balance of pro- and anti-inflammatory cytokines released during the operation, we measured levels of tumor necrosis factor-α (TNFα), interleukin (IL)-1β, IL-6 and IL-10 in 19 patients undergoing liver resection. The results showed a continuous rise of IL-6 and a transient elevation of IL-10. Levels of TNFα remained low; IL-1β was not detected at any sampling time. We conclude that liver surgery induces cytokine response characterized predominantly by an early appearance of IL-6 and IL-10, the elevation of IL-6 may be mainly caused by splanchnic ischemia. The IL-6/IL-10 ratio could possibly reflect the balance of pro- and anti-inflammatory cytokines in liver surgery better than the TNFα/IL-10 ratio, which can well represent inflammatory status in sepsis. |
| doi_str_mv | 10.1515/CCLM.2003.136 |
| format | Article |
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Many cytokines are produced by macrophages; therefore surgical injuries to the liver may have great influence on the release of cytokines. Ischemia creates tissue injury and may contribute to the cytokine release. A balanced ratio of pro- and anti-inflammatory cytokines is important for appropriate immune response; excessive inflammation or hypo-responsiveness can lead to post-operative complications. To determine the magnitude of the cytokine response caused by liver surgery and to evaluate the balance of pro- and anti-inflammatory cytokines released during the operation, we measured levels of tumor necrosis factor-α (TNFα), interleukin (IL)-1β, IL-6 and IL-10 in 19 patients undergoing liver resection. The results showed a continuous rise of IL-6 and a transient elevation of IL-10. Levels of TNFα remained low; IL-1β was not detected at any sampling time. We conclude that liver surgery induces cytokine response characterized predominantly by an early appearance of IL-6 and IL-10, the elevation of IL-6 may be mainly caused by splanchnic ischemia. The IL-6/IL-10 ratio could possibly reflect the balance of pro- and anti-inflammatory cytokines in liver surgery better than the TNFα/IL-10 ratio, which can well represent inflammatory status in sepsis.</description><identifier>ISSN: 1434-6621</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/CCLM.2003.136</identifier><identifier>PMID: 12940515</identifier><language>eng</language><publisher>Berlin: Walter de Gruyter</publisher><subject>Biological and medical sciences ; Biomarkers - blood ; Confidence Intervals ; Cytokines - blood ; Female ; Humans ; Inflammation ; Interleukin-10 - blood ; Interleukin-6 - blood ; Liver Neoplasms - blood ; Liver Neoplasms - immunology ; Liver Neoplasms - surgery ; Liver, biliary tract, pancreas, portal circulation, spleen ; Male ; Medical sciences ; Reference Values ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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Many cytokines are produced by macrophages; therefore surgical injuries to the liver may have great influence on the release of cytokines. Ischemia creates tissue injury and may contribute to the cytokine release. A balanced ratio of pro- and anti-inflammatory cytokines is important for appropriate immune response; excessive inflammation or hypo-responsiveness can lead to post-operative complications. To determine the magnitude of the cytokine response caused by liver surgery and to evaluate the balance of pro- and anti-inflammatory cytokines released during the operation, we measured levels of tumor necrosis factor-α (TNFα), interleukin (IL)-1β, IL-6 and IL-10 in 19 patients undergoing liver resection. The results showed a continuous rise of IL-6 and a transient elevation of IL-10. Levels of TNFα remained low; IL-1β was not detected at any sampling time. We conclude that liver surgery induces cytokine response characterized predominantly by an early appearance of IL-6 and IL-10, the elevation of IL-6 may be mainly caused by splanchnic ischemia. The IL-6/IL-10 ratio could possibly reflect the balance of pro- and anti-inflammatory cytokines in liver surgery better than the TNFα/IL-10 ratio, which can well represent inflammatory status in sepsis.</description><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Confidence Intervals</subject><subject>Cytokines - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin-10 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - immunology</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Reference Values</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><issn>1434-6621</issn><issn>1437-4331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAQgC0EoqUwsqIssKX47WQDApSiIooos-W4NgrNo9gJov8el1Z0ZLqT7rvXB8ApgkPEELvMssnTEENIhojwPdBHlIiYEoL2f3Mac45RDxx5_wEhYoyKQ9BDOKUwdPfB1Y0qVa1N1Nho6po4UvU8uq7bIh7XtlRVpdrGraJs1TaLojY-KupoUnwZF7127t241TE4sKr05mQbB-Dt_m6WPcST59E4u57EmiakjS2fC61oknPKtWZEiBwzOkdpohOqmTapSaxNMOQ2FxRDZihBFGrMkxyFChmAi83cpWs-O-NbWRVemzJcb5rOS0E45AThf0EME8jSFAYw3oDaNd47Y-XSFZVyK4mgXLuVa7dy7VYGt4E_2w7u8srMd_RWZgDOt4DyWpXWBbGF33EMhp-Q2C0ufGu-_-rKLSQXRDD5MqMyFbMpGz1ieUt-AJ7_jfs</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>Jerin, Aleš</creator><creator>Požar-Lukanovič, Neva</creator><creator>Sojar, Valentin</creator><creator>Stanisavljevič, Dragoje</creator><creator>Paver-Eržen, Vesna</creator><creator>Osredkar, Joško</creator><general>Walter de Gruyter</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20030701</creationdate><title>Balance of Pro- and Anti-Inflammatory Cytokines in Liver Surgery</title><author>Jerin, Aleš ; Požar-Lukanovič, Neva ; Sojar, Valentin ; Stanisavljevič, Dragoje ; Paver-Eržen, Vesna ; Osredkar, Joško</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-f6d7ca48b646cc5377b254d198c84c5ce9e8ff8206fb74205e43140c268b18ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Confidence Intervals</topic><topic>Cytokines - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin-10 - blood</topic><topic>Interleukin-6 - blood</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - immunology</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Reference Values</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jerin, Aleš</creatorcontrib><creatorcontrib>Požar-Lukanovič, Neva</creatorcontrib><creatorcontrib>Sojar, Valentin</creatorcontrib><creatorcontrib>Stanisavljevič, Dragoje</creatorcontrib><creatorcontrib>Paver-Eržen, Vesna</creatorcontrib><creatorcontrib>Osredkar, Joško</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry and laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jerin, Aleš</au><au>Požar-Lukanovič, Neva</au><au>Sojar, Valentin</au><au>Stanisavljevič, Dragoje</au><au>Paver-Eržen, Vesna</au><au>Osredkar, Joško</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Balance of Pro- and Anti-Inflammatory Cytokines in Liver Surgery</atitle><jtitle>Clinical chemistry and laboratory medicine</jtitle><addtitle>Clinical Chemistry and Laboratory Medicine</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>41</volume><issue>7</issue><spage>899</spage><epage>903</epage><pages>899-903</pages><issn>1434-6621</issn><eissn>1437-4331</eissn><abstract>Inflammatory response in surgery is associated with the release of cytokines. Many cytokines are produced by macrophages; therefore surgical injuries to the liver may have great influence on the release of cytokines. Ischemia creates tissue injury and may contribute to the cytokine release. A balanced ratio of pro- and anti-inflammatory cytokines is important for appropriate immune response; excessive inflammation or hypo-responsiveness can lead to post-operative complications. To determine the magnitude of the cytokine response caused by liver surgery and to evaluate the balance of pro- and anti-inflammatory cytokines released during the operation, we measured levels of tumor necrosis factor-α (TNFα), interleukin (IL)-1β, IL-6 and IL-10 in 19 patients undergoing liver resection. The results showed a continuous rise of IL-6 and a transient elevation of IL-10. Levels of TNFα remained low; IL-1β was not detected at any sampling time. We conclude that liver surgery induces cytokine response characterized predominantly by an early appearance of IL-6 and IL-10, the elevation of IL-6 may be mainly caused by splanchnic ischemia. The IL-6/IL-10 ratio could possibly reflect the balance of pro- and anti-inflammatory cytokines in liver surgery better than the TNFα/IL-10 ratio, which can well represent inflammatory status in sepsis.</abstract><cop>Berlin</cop><cop>New York, NY</cop><pub>Walter de Gruyter</pub><pmid>12940515</pmid><doi>10.1515/CCLM.2003.136</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; De Gruyter journals |
| subjects | Biological and medical sciences Biomarkers - blood Confidence Intervals Cytokines - blood Female Humans Inflammation Interleukin-10 - blood Interleukin-6 - blood Liver Neoplasms - blood Liver Neoplasms - immunology Liver Neoplasms - surgery Liver, biliary tract, pancreas, portal circulation, spleen Male Medical sciences Reference Values Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Tumor Necrosis Factor-alpha - analysis |
| title | Balance of Pro- and Anti-Inflammatory Cytokines in Liver Surgery |
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