Emergence of Tumorigenic Cells during the Course of Friend Virus Leukemias
Appearance of tumorigenic cells was studied in DBA/2 and ICFW mice infected either with the polycythemia-inducing or the anemia-inducing strain of Friend leukemia virus. Tumorigenicity was defined by transplantability of virus-infected cells into the omentum of an isogeneic preirradiated host. Tumor...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1981-06, Vol.78 (6), p.3614-3618 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Wendling, Françoise Moreau-Gachelin, Françoise Tambourin, Pierre |
| description | Appearance of tumorigenic cells was studied in DBA/2 and ICFW mice infected either with the polycythemia-inducing or the anemia-inducing strain of Friend leukemia virus. Tumorigenicity was defined by transplantability of virus-infected cells into the omentum of an isogeneic preirradiated host. Tumorigenic cells were detected in 50% of the leukemic donors 3 wk after infection by the polycythemia-inducing strain and 7-8 wk after infection by the anemia-inducing strain. These cells appeared first in the spleen and later in peripheral blood, bone marrow, and liver. They consisted of a heterogeneous population at different degrees of malignancy as determined by successive transfers in vivo and in vitro. The observations clearly show that leukemias induced by Friend viruses evolve by multistep processes, in which different stages of malignancy can be detected. |
| doi_str_mv | 10.1073/pnas.78.6.3614 |
| format | Article |
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Tumorigenicity was defined by transplantability of virus-infected cells into the omentum of an isogeneic preirradiated host. Tumorigenic cells were detected in 50% of the leukemic donors 3 wk after infection by the polycythemia-inducing strain and 7-8 wk after infection by the anemia-inducing strain. These cells appeared first in the spleen and later in peripheral blood, bone marrow, and liver. They consisted of a heterogeneous population at different degrees of malignancy as determined by successive transfers in vivo and in vitro. The observations clearly show that leukemias induced by Friend viruses evolve by multistep processes, in which different stages of malignancy can be detected.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.78.6.3614</identifier><identifier>PMID: 6943562</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Cell lines ; Friend murine leukemia virus ; Infections ; Leukemia ; Leukemia, Erythroblastic, Acute - pathology ; Leukemia, Experimental - pathology ; Liver ; Mice ; Neoplasm Transplantation ; Radiation Chimera ; Spleen ; Spleen - pathology ; Time Factors ; Tissue grafting ; Tumor cell line ; Tumors ; Viruses</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1981-06, Vol.78 (6), p.3614-3618</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-fd3310bc46ad390aa4cf9cb468861a2671fd3bee55c3e10275361e189bb57c4b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/78/6.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/10886$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/10886$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6943562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wendling, Françoise</creatorcontrib><creatorcontrib>Moreau-Gachelin, Françoise</creatorcontrib><creatorcontrib>Tambourin, Pierre</creatorcontrib><title>Emergence of Tumorigenic Cells during the Course of Friend Virus Leukemias</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Appearance of tumorigenic cells was studied in DBA/2 and ICFW mice infected either with the polycythemia-inducing or the anemia-inducing strain of Friend leukemia virus. Tumorigenicity was defined by transplantability of virus-infected cells into the omentum of an isogeneic preirradiated host. Tumorigenic cells were detected in 50% of the leukemic donors 3 wk after infection by the polycythemia-inducing strain and 7-8 wk after infection by the anemia-inducing strain. These cells appeared first in the spleen and later in peripheral blood, bone marrow, and liver. They consisted of a heterogeneous population at different degrees of malignancy as determined by successive transfers in vivo and in vitro. The observations clearly show that leukemias induced by Friend viruses evolve by multistep processes, in which different stages of malignancy can be detected.</description><subject>Animals</subject><subject>Cell lines</subject><subject>Friend murine leukemia virus</subject><subject>Infections</subject><subject>Leukemia</subject><subject>Leukemia, Erythroblastic, Acute - pathology</subject><subject>Leukemia, Experimental - pathology</subject><subject>Liver</subject><subject>Mice</subject><subject>Neoplasm Transplantation</subject><subject>Radiation Chimera</subject><subject>Spleen</subject><subject>Spleen - pathology</subject><subject>Time Factors</subject><subject>Tissue grafting</subject><subject>Tumor cell line</subject><subject>Tumors</subject><subject>Viruses</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkDtPwzAUhS0EKuWxMiAhZWJLsGPHSQYGVPFUJZbCajnOTTEkcbFjBP8el5aqSEyWdb5z7z0HoROCE4JzerHopUvyIuEJ5YTtoDHBJYk5K_EuGmOc5nHBUraPDpx7xRiXWYFHaMRLRjOejtHDdQd2Dr2CyDTRzHfG6vDVKppA27qo9lb382h4gWhivHU_2I3V0NfRs7beRVPwb9Bp6Y7QXiNbB8fr9xA93VzPJnfx9PH2fnI1jVWWkSFuakoJrhTjsqYllpKpplQV40XBiUx5TgJRAWSZokBCgCwEA1KUVZXlilX0EF2u5i581UGtoB-sbMXC6k7aL2GkFn-VXr-IufkQlJQ8JcF_vvZb8-7BDaLTToW0sgfjncgpx5ziIoDJClTWOGeh2ewgWCzLF8vyRV4ILpblB8PZ9mUbfN321ual71fd-EXj23aAz2Fr0L9g0E9X-qsbjN06K3RIvwGJf6H8</recordid><startdate>19810601</startdate><enddate>19810601</enddate><creator>Wendling, Françoise</creator><creator>Moreau-Gachelin, Françoise</creator><creator>Tambourin, Pierre</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19810601</creationdate><title>Emergence of Tumorigenic Cells during the Course of Friend Virus Leukemias</title><author>Wendling, Françoise ; Moreau-Gachelin, Françoise ; Tambourin, Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-fd3310bc46ad390aa4cf9cb468861a2671fd3bee55c3e10275361e189bb57c4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Cell lines</topic><topic>Friend murine leukemia virus</topic><topic>Infections</topic><topic>Leukemia</topic><topic>Leukemia, Erythroblastic, Acute - pathology</topic><topic>Leukemia, Experimental - pathology</topic><topic>Liver</topic><topic>Mice</topic><topic>Neoplasm Transplantation</topic><topic>Radiation Chimera</topic><topic>Spleen</topic><topic>Spleen - pathology</topic><topic>Time Factors</topic><topic>Tissue grafting</topic><topic>Tumor cell line</topic><topic>Tumors</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wendling, Françoise</creatorcontrib><creatorcontrib>Moreau-Gachelin, Françoise</creatorcontrib><creatorcontrib>Tambourin, Pierre</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wendling, Françoise</au><au>Moreau-Gachelin, Françoise</au><au>Tambourin, Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emergence of Tumorigenic Cells during the Course of Friend Virus Leukemias</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1981-06-01</date><risdate>1981</risdate><volume>78</volume><issue>6</issue><spage>3614</spage><epage>3618</epage><pages>3614-3618</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Appearance of tumorigenic cells was studied in DBA/2 and ICFW mice infected either with the polycythemia-inducing or the anemia-inducing strain of Friend leukemia virus. 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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1981-06, Vol.78 (6), p.3614-3618 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Cell lines Friend murine leukemia virus Infections Leukemia Leukemia, Erythroblastic, Acute - pathology Leukemia, Experimental - pathology Liver Mice Neoplasm Transplantation Radiation Chimera Spleen Spleen - pathology Time Factors Tissue grafting Tumor cell line Tumors Viruses |
| title | Emergence of Tumorigenic Cells during the Course of Friend Virus Leukemias |
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