Abietic acid activates peroxisome proliferator-activated receptor-γ (PPARγ) in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism

Abietic acid is one of the terpenoids, which are multifunctional natural compounds. It has been reported that abietic acid suppresses effects on inflammation. However, the mechanism underlying the anti-inflammatory effects remains unclear. The present work indicates that abietic acid suppresses the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	FEBS letters 2003-08, Vol.550 (1), p.190-194
Hauptverfasser:	Takahashi, Nobuyuki, Kawada, Teruo, Goto, Tsuyoshi, Kim, Chu-Sook, Taimatsu, Aki, Egawa, Kahori, Yamamoto, Takayuki, Jisaka, Mitsuo, Nishimura, Koji, Yokota, Kazushige, Yu, Rina, Fushiki, Tohru
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells - drug effects Abietic acid Adipocyte Adipocytes - drug effects Adipocytes - metabolism Animals Anti-inflammatory aP2, adipocyte fatty acid-binding protein BADGE, bisphenol A diglycidyl ether CBP, CREB-binding protein CD36 Antigens - drug effects CD36 Antigens - genetics Cells, Cultured COX2, cyclooxygenase 2 CREB, cAMP response element-binding protein CREB-Binding Protein Cyclooxygenase 2 Diterpenes - pharmacology Diterpenes, Abietane GAPDH, glyceraldehyde-3-phosphate dehydrogenase Gene Expression Regulation - drug effects Inflammation - genetics Isoenzymes - drug effects Isoenzymes - genetics Isoenzymes - metabolism Ligands Lipid Metabolism Lipopolysaccharides - pharmacology LPL, lipoprotein lipase LPS, lipopolysaccharide Luciferases - drug effects Luciferases - genetics Luciferases - metabolism Macrophage Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Male Mice Mice, Inbred BALB C Nuclear Proteins - drug effects Nuclear Proteins - genetics Nutrigenomics Peroxisome proliferator-activated receptor-γ Phenanthrenes - pharmacology PPAR, peroxisome proliferator-activated receptor Prostaglandin-Endoperoxide Synthases - drug effects Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism Receptors, Cytoplasmic and Nuclear - drug effects Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Terpenoid Thiazoles - pharmacology Thiazolidinediones TNF-α, tumor necrosis factor-α Trans-Activators - drug effects Trans-Activators - genetics Transcription Factors - drug effects Transcription Factors - genetics Transcription Factors - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism TZD, thiazolidinedione
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!