(−)-9-Dehydrogalanthaminium bromide, a new cholinesterase inhibitor, enhances place and object recognition memory in young and old rats
In a previous study, we showed that (−)-9-dehydrogalanthaminium bromide, a synthetic galanthamine derivative, was more potent than galanthamine in inhibiting acetylcholinesterase. We studied here the action of this new compound on recognition memory in young and old rats, using a two-trial recogniti...
Gespeichert in:
| Veröffentlicht in: | Neurobiology of learning and memory 2003-09, Vol.80 (2), p.113-122 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 122 |
|---|---|
| container_issue | 2 |
| container_start_page | 113 |
| container_title | Neurobiology of learning and memory |
| container_volume | 80 |
| creator | Lamirault, Laëtitia Guillou, Catherine Thal, Claude Simon, Hervé |
| description | In a previous study, we showed that (−)-9-dehydrogalanthaminium bromide, a synthetic galanthamine derivative, was more potent than galanthamine in inhibiting acetylcholinesterase. We studied here the action of this new compound on recognition memory in young and old rats, using a two-trial recognition task designed to test both place and object recognition. (−)-9-dehydrogalanthaminium bromide was injected (0.3, 1, and 3
mg/kg, i.p.) in young and old rats before the acquisition phase, immediately after it, or before the retrieval phase of the task, in order to determine the stage of information processing affected by the compound. (−)-9-dehydrogalanthaminium bromide improved both place and object recognition in young rats, via an enhancement of acquisition (3
mg/kg: place recognition; 1 and 3
mg/kg: object recognition) and consolidation (1 and 3
mg/kg) information processing. In old rats, (−)-9-dehydrogalanthaminium bromide improved performance by acting on the acquisition processes of place (0.3, 1, and 3
mg/kg) and object (1 and 3
mg/kg) recognition. These results provide information on the profile of activity of (−)-9-dehydrogalanthaminium bromide on memory processes, and suggest that this new compound could have utility in the treatment of cognitive dysfunction occurring in Alzheimer’s disease or in the normal course of aging. |
| doi_str_mv | 10.1016/S1074-7427(03)00064-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73604271</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1074742703000649</els_id><sourcerecordid>18942362</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-a0c4ee776062ef9f61067a7f30557e007682b7f81f52aac485abf4a86da3f9283</originalsourceid><addsrcrecordid>eNqFkctu1DAUhiMEohd4BJA3oFZq4Nhx7HhVoXKVKrEA1pbjnExcJfZgJ6B5g7LlEXkSPJ1IXXZlL77_2Of_iuIFhTcUqHj7jYLkpeRMnkF1DgCCl-pRcUxB1aWqBX-8v6_IUXGS0g0ApbVqnhZHlKmKcSaOiz9n_27_npeqfI_DrothY0bj58FMzrtlIm0Mk-vwghji8TexQxidxzRjNAmJ84Nr3RziBUE_GG8xke1oLBLjOxLaG7QziWjDxrvZBU8mnELc5RzZhcVvDtjYkWjm9Kx40psx4fP1PC1-fPzw_epzef3105erd9el5ZLPpQHLEaUUIBj2qhcUhDSyr6CuJQJI0bBW9g3ta2aM5U1t2p6bRnSm6hVrqtPi9WHuNoafS95FTy5ZHPPeGJakZSUgV0YfBGmjOKsEy2B9AG0MKUXs9Ta6ycSdpqD3svSdLL03oaHSd7K0yrmX6wNLO2F3n1rtZODVCphkzdjHXLFL91xNKTAGmbs8cJh7--Uw6mQdZh2dy-3Pugvuga_8B7gNss4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18942362</pqid></control><display><type>article</type><title>(−)-9-Dehydrogalanthaminium bromide, a new cholinesterase inhibitor, enhances place and object recognition memory in young and old rats</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Lamirault, Laëtitia ; Guillou, Catherine ; Thal, Claude ; Simon, Hervé</creator><creatorcontrib>Lamirault, Laëtitia ; Guillou, Catherine ; Thal, Claude ; Simon, Hervé</creatorcontrib><description>In a previous study, we showed that (−)-9-dehydrogalanthaminium bromide, a synthetic galanthamine derivative, was more potent than galanthamine in inhibiting acetylcholinesterase. We studied here the action of this new compound on recognition memory in young and old rats, using a two-trial recognition task designed to test both place and object recognition. (−)-9-dehydrogalanthaminium bromide was injected (0.3, 1, and 3
mg/kg, i.p.) in young and old rats before the acquisition phase, immediately after it, or before the retrieval phase of the task, in order to determine the stage of information processing affected by the compound. (−)-9-dehydrogalanthaminium bromide improved both place and object recognition in young rats, via an enhancement of acquisition (3
mg/kg: place recognition; 1 and 3
mg/kg: object recognition) and consolidation (1 and 3
mg/kg) information processing. In old rats, (−)-9-dehydrogalanthaminium bromide improved performance by acting on the acquisition processes of place (0.3, 1, and 3
mg/kg) and object (1 and 3
mg/kg) recognition. These results provide information on the profile of activity of (−)-9-dehydrogalanthaminium bromide on memory processes, and suggest that this new compound could have utility in the treatment of cognitive dysfunction occurring in Alzheimer’s disease or in the normal course of aging.</description><identifier>ISSN: 1074-7427</identifier><identifier>EISSN: 1095-9564</identifier><identifier>DOI: 10.1016/S1074-7427(03)00064-9</identifier><identifier>PMID: 12932426</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>(-)-9-Dehydrogalanthaminium bromide ; (−)-9-Dehydrogalanthaminium bromide ; Acetylcholinesterase inhibitor ; Age Factors ; Aging ; Aging - physiology ; Animal ; Animals ; Biological and medical sciences ; Cholinesterase Inhibitors - administration & dosage ; Cholinesterase Inhibitors - pharmacology ; Cognition - drug effects ; Fundamental and applied biological sciences. Psychology ; Galantamine - administration & dosage ; Galantamine - analogs & derivatives ; Galantamine - pharmacology ; Galanthamine ; Injections ; Learning. Memory ; Male ; Maze Learning - drug effects ; Memory ; Memory - drug effects ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rat ; Rats ; Rats, Sprague-Dawley ; Recognition (Psychology) - drug effects ; Recognition memory ; Y-maze</subject><ispartof>Neurobiology of learning and memory, 2003-09, Vol.80 (2), p.113-122</ispartof><rights>2003 Elsevier Science (USA)</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-a0c4ee776062ef9f61067a7f30557e007682b7f81f52aac485abf4a86da3f9283</citedby><cites>FETCH-LOGICAL-c474t-a0c4ee776062ef9f61067a7f30557e007682b7f81f52aac485abf4a86da3f9283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1074742703000649$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15110220$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12932426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lamirault, Laëtitia</creatorcontrib><creatorcontrib>Guillou, Catherine</creatorcontrib><creatorcontrib>Thal, Claude</creatorcontrib><creatorcontrib>Simon, Hervé</creatorcontrib><title>(−)-9-Dehydrogalanthaminium bromide, a new cholinesterase inhibitor, enhances place and object recognition memory in young and old rats</title><title>Neurobiology of learning and memory</title><addtitle>Neurobiol Learn Mem</addtitle><description>In a previous study, we showed that (−)-9-dehydrogalanthaminium bromide, a synthetic galanthamine derivative, was more potent than galanthamine in inhibiting acetylcholinesterase. We studied here the action of this new compound on recognition memory in young and old rats, using a two-trial recognition task designed to test both place and object recognition. (−)-9-dehydrogalanthaminium bromide was injected (0.3, 1, and 3
mg/kg, i.p.) in young and old rats before the acquisition phase, immediately after it, or before the retrieval phase of the task, in order to determine the stage of information processing affected by the compound. (−)-9-dehydrogalanthaminium bromide improved both place and object recognition in young rats, via an enhancement of acquisition (3
mg/kg: place recognition; 1 and 3
mg/kg: object recognition) and consolidation (1 and 3
mg/kg) information processing. In old rats, (−)-9-dehydrogalanthaminium bromide improved performance by acting on the acquisition processes of place (0.3, 1, and 3
mg/kg) and object (1 and 3
mg/kg) recognition. These results provide information on the profile of activity of (−)-9-dehydrogalanthaminium bromide on memory processes, and suggest that this new compound could have utility in the treatment of cognitive dysfunction occurring in Alzheimer’s disease or in the normal course of aging.</description><subject>(-)-9-Dehydrogalanthaminium bromide</subject><subject>(−)-9-Dehydrogalanthaminium bromide</subject><subject>Acetylcholinesterase inhibitor</subject><subject>Age Factors</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Animal</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cholinesterase Inhibitors - administration & dosage</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Cognition - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Galantamine - administration & dosage</subject><subject>Galantamine - analogs & derivatives</subject><subject>Galantamine - pharmacology</subject><subject>Galanthamine</subject><subject>Injections</subject><subject>Learning. Memory</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Memory</subject><subject>Memory - drug effects</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recognition (Psychology) - drug effects</subject><subject>Recognition memory</subject><subject>Y-maze</subject><issn>1074-7427</issn><issn>1095-9564</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUhiMEohd4BJA3oFZq4Nhx7HhVoXKVKrEA1pbjnExcJfZgJ6B5g7LlEXkSPJ1IXXZlL77_2Of_iuIFhTcUqHj7jYLkpeRMnkF1DgCCl-pRcUxB1aWqBX-8v6_IUXGS0g0ApbVqnhZHlKmKcSaOiz9n_27_npeqfI_DrothY0bj58FMzrtlIm0Mk-vwghji8TexQxidxzRjNAmJ84Nr3RziBUE_GG8xke1oLBLjOxLaG7QziWjDxrvZBU8mnELc5RzZhcVvDtjYkWjm9Kx40psx4fP1PC1-fPzw_epzef3105erd9el5ZLPpQHLEaUUIBj2qhcUhDSyr6CuJQJI0bBW9g3ta2aM5U1t2p6bRnSm6hVrqtPi9WHuNoafS95FTy5ZHPPeGJakZSUgV0YfBGmjOKsEy2B9AG0MKUXs9Ta6ycSdpqD3svSdLL03oaHSd7K0yrmX6wNLO2F3n1rtZODVCphkzdjHXLFL91xNKTAGmbs8cJh7--Uw6mQdZh2dy-3Pugvuga_8B7gNss4</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>Lamirault, Laëtitia</creator><creator>Guillou, Catherine</creator><creator>Thal, Claude</creator><creator>Simon, Hervé</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>(−)-9-Dehydrogalanthaminium bromide, a new cholinesterase inhibitor, enhances place and object recognition memory in young and old rats</title><author>Lamirault, Laëtitia ; Guillou, Catherine ; Thal, Claude ; Simon, Hervé</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-a0c4ee776062ef9f61067a7f30557e007682b7f81f52aac485abf4a86da3f9283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>(-)-9-Dehydrogalanthaminium bromide</topic><topic>(−)-9-Dehydrogalanthaminium bromide</topic><topic>Acetylcholinesterase inhibitor</topic><topic>Age Factors</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Animal</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cholinesterase Inhibitors - administration & dosage</topic><topic>Cholinesterase Inhibitors - pharmacology</topic><topic>Cognition - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Galantamine - administration & dosage</topic><topic>Galantamine - analogs & derivatives</topic><topic>Galantamine - pharmacology</topic><topic>Galanthamine</topic><topic>Injections</topic><topic>Learning. Memory</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Memory</topic><topic>Memory - drug effects</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Recognition (Psychology) - drug effects</topic><topic>Recognition memory</topic><topic>Y-maze</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lamirault, Laëtitia</creatorcontrib><creatorcontrib>Guillou, Catherine</creatorcontrib><creatorcontrib>Thal, Claude</creatorcontrib><creatorcontrib>Simon, Hervé</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of learning and memory</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lamirault, Laëtitia</au><au>Guillou, Catherine</au><au>Thal, Claude</au><au>Simon, Hervé</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>(−)-9-Dehydrogalanthaminium bromide, a new cholinesterase inhibitor, enhances place and object recognition memory in young and old rats</atitle><jtitle>Neurobiology of learning and memory</jtitle><addtitle>Neurobiol Learn Mem</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>80</volume><issue>2</issue><spage>113</spage><epage>122</epage><pages>113-122</pages><issn>1074-7427</issn><eissn>1095-9564</eissn><abstract>In a previous study, we showed that (−)-9-dehydrogalanthaminium bromide, a synthetic galanthamine derivative, was more potent than galanthamine in inhibiting acetylcholinesterase. We studied here the action of this new compound on recognition memory in young and old rats, using a two-trial recognition task designed to test both place and object recognition. (−)-9-dehydrogalanthaminium bromide was injected (0.3, 1, and 3
mg/kg, i.p.) in young and old rats before the acquisition phase, immediately after it, or before the retrieval phase of the task, in order to determine the stage of information processing affected by the compound. (−)-9-dehydrogalanthaminium bromide improved both place and object recognition in young rats, via an enhancement of acquisition (3
mg/kg: place recognition; 1 and 3
mg/kg: object recognition) and consolidation (1 and 3
mg/kg) information processing. In old rats, (−)-9-dehydrogalanthaminium bromide improved performance by acting on the acquisition processes of place (0.3, 1, and 3
mg/kg) and object (1 and 3
mg/kg) recognition. These results provide information on the profile of activity of (−)-9-dehydrogalanthaminium bromide on memory processes, and suggest that this new compound could have utility in the treatment of cognitive dysfunction occurring in Alzheimer’s disease or in the normal course of aging.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>12932426</pmid><doi>10.1016/S1074-7427(03)00064-9</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1074-7427 |
| ispartof | Neurobiology of learning and memory, 2003-09, Vol.80 (2), p.113-122 |
| issn | 1074-7427 1095-9564 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73604271 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | (-)-9-Dehydrogalanthaminium bromide (−)-9-Dehydrogalanthaminium bromide Acetylcholinesterase inhibitor Age Factors Aging Aging - physiology Animal Animals Biological and medical sciences Cholinesterase Inhibitors - administration & dosage Cholinesterase Inhibitors - pharmacology Cognition - drug effects Fundamental and applied biological sciences. Psychology Galantamine - administration & dosage Galantamine - analogs & derivatives Galantamine - pharmacology Galanthamine Injections Learning. Memory Male Maze Learning - drug effects Memory Memory - drug effects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rat Rats Rats, Sprague-Dawley Recognition (Psychology) - drug effects Recognition memory Y-maze |
| title | (−)-9-Dehydrogalanthaminium bromide, a new cholinesterase inhibitor, enhances place and object recognition memory in young and old rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T00%3A19%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=(%E2%88%92)-9-Dehydrogalanthaminium%20bromide,%20a%20new%20cholinesterase%20inhibitor,%20enhances%20place%20and%20object%20recognition%20memory%20in%20young%20and%20old%20rats&rft.jtitle=Neurobiology%20of%20learning%20and%20memory&rft.au=Lamirault,%20La%C3%ABtitia&rft.date=2003-09-01&rft.volume=80&rft.issue=2&rft.spage=113&rft.epage=122&rft.pages=113-122&rft.issn=1074-7427&rft.eissn=1095-9564&rft_id=info:doi/10.1016/S1074-7427(03)00064-9&rft_dat=%3Cproquest_cross%3E18942362%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18942362&rft_id=info:pmid/12932426&rft_els_id=S1074742703000649&rfr_iscdi=true |