Repression of MUC2 gene expression by butyrate, a physiological regulator of intestinal cell maturation

Sodium butyrate (NaB) inhibits proliferation, stimulates apoptosis, and promotes differentiation of human colon cancer cells along the absorptive phenotype. In vitro , butyrate induces a switch from cells with a secretory to an absorptive phenotype. Here, we report that NaB specifically represses th...

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Veröffentlicht in:	Oncogene 2003-08, Vol.22 (32), p.4983-4992
Hauptverfasser:	Augenlicht, Leonard, Shi, Li, Mariadason, John, Laboisse, Christian, Velcich, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Apoptosis Biological and medical sciences Butyrates - pharmacology Carcinoembryonic antigen Cell Biology Cell differentiation Cell Differentiation - drug effects Cell Differentiation - physiology Cell lineage Cell proliferation Colon cancer Colorectal cancer Forskolin Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation - drug effects Genes. Genome Genotype & phenotype Goblet cells Histone deacetylase Homeostasis Human Genetics Humans Hydroxamic Acids - pharmacology Internal Medicine Intestine Kinases Medicine Medicine & Public Health Mitogen-Activated Protein Kinases - antagonists & inhibitors Molecular and cellular biology Molecular genetics MUC2 gene Mucin-2 Mucins - biosynthesis Mucins - drug effects Mucins - genetics Oncology original-paper Phenotypes Physiology Protein biosynthesis Protein Synthesis Inhibitors - pharmacology Proteins Sodium butyrate Trichostatin A
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