Association of dopamine D4 receptor (DRD4) exon III repeat polymorphism with temperament in 3-year-old infants
The long forms of the dopamine D4 receptor (DRD4) exon III repeat polymorphism (L-DRD4) have been linked in some studies to the adult personality trait of novelty seeking (NS), as well as to infant personality traits related to interest and activity. The current investigation extends the results of...
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| Veröffentlicht in: | Neurogenetics 2003-08, Vol.4 (4), p.207-212 |
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| creator | DE LUCA, Alessandro RIZZARDI, Mario BUCCINO, Anna ALESSANDRONI, Rosina SALVIOLI, Gian Paolo FILOGRASSO, Nando NOVELLI, Giuseppe DALLAPICCOLA, Bruno |
| description | The long forms of the dopamine D4 receptor (DRD4) exon III repeat polymorphism (L-DRD4) have been linked in some studies to the adult personality trait of novelty seeking (NS), as well as to infant personality traits related to interest and activity. The current investigation extends the results of our previous longitudinal study on 1- to 5-month-old neonates assessed by the Early and Revised Infancy Temperament Questionnaire (EITQ/RITQ), in which we found a significant correlation between the DRD4 polymorphism and the adaptability trait at 1 month of age. In this study, we examined the relationship between children's behavior at 3 years of age, measured with the Toddler Temperament Scale (TTS), and DRD4 exon III repeat polymorphism. We found a significant association between the behavioral dimension of intensity of reaction and DRD4 genotypes. Current data failed to confirm the association with the adaptability trait. None of the extraversion and/or exploratory behavior measures was related to the L-DRD4 allele, as expected. In contrast, children with 4/7 genotypes showed worse response to new stimuli compared with 4/4 genotypes. This study corroborates only in part previous results on the link between the DRD4 gene and human temperament. |
| doi_str_mv | 10.1007/s10048-003-0146-z |
| format | Article |
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The current investigation extends the results of our previous longitudinal study on 1- to 5-month-old neonates assessed by the Early and Revised Infancy Temperament Questionnaire (EITQ/RITQ), in which we found a significant correlation between the DRD4 polymorphism and the adaptability trait at 1 month of age. In this study, we examined the relationship between children's behavior at 3 years of age, measured with the Toddler Temperament Scale (TTS), and DRD4 exon III repeat polymorphism. We found a significant association between the behavioral dimension of intensity of reaction and DRD4 genotypes. Current data failed to confirm the association with the adaptability trait. None of the extraversion and/or exploratory behavior measures was related to the L-DRD4 allele, as expected. In contrast, children with 4/7 genotypes showed worse response to new stimuli compared with 4/4 genotypes. This study corroborates only in part previous results on the link between the DRD4 gene and human temperament.</description><identifier>ISSN: 1364-6745</identifier><identifier>EISSN: 1364-6753</identifier><identifier>DOI: 10.1007/s10048-003-0146-z</identifier><identifier>PMID: 12687422</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Babies ; Behavioral psychophysiology ; Biological and medical sciences ; Child Behavior - physiology ; Child, Preschool ; Exons ; Exploratory Behavior - physiology ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; General aspects. Genetic counseling ; Genetics ; Humans ; Male ; Medical genetics ; Medical sciences ; Miscellaneous ; Neurotransmitters ; Personality traits ; Polymorphism, Genetic ; Psychology. Psychoanalysis. Psychiatry ; Psychology. 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The current investigation extends the results of our previous longitudinal study on 1- to 5-month-old neonates assessed by the Early and Revised Infancy Temperament Questionnaire (EITQ/RITQ), in which we found a significant correlation between the DRD4 polymorphism and the adaptability trait at 1 month of age. In this study, we examined the relationship between children's behavior at 3 years of age, measured with the Toddler Temperament Scale (TTS), and DRD4 exon III repeat polymorphism. We found a significant association between the behavioral dimension of intensity of reaction and DRD4 genotypes. Current data failed to confirm the association with the adaptability trait. None of the extraversion and/or exploratory behavior measures was related to the L-DRD4 allele, as expected. In contrast, children with 4/7 genotypes showed worse response to new stimuli compared with 4/4 genotypes. This study corroborates only in part previous results on the link between the DRD4 gene and human temperament.</description><subject>Babies</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Child Behavior - physiology</subject><subject>Child, Preschool</subject><subject>Exons</subject><subject>Exploratory Behavior - physiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects. Genetic counseling</subject><subject>Genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Neurotransmitters</subject><subject>Personality traits</subject><subject>Polymorphism, Genetic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. 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Psychology</topic><topic>General aspects. Genetic counseling</topic><topic>Genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Neurotransmitters</topic><topic>Personality traits</topic><topic>Polymorphism, Genetic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Receptors, Dopamine D2 - genetics</topic><topic>Receptors, Dopamine D4</topic><topic>Temperament - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DE LUCA, Alessandro</creatorcontrib><creatorcontrib>RIZZARDI, Mario</creatorcontrib><creatorcontrib>BUCCINO, Anna</creatorcontrib><creatorcontrib>ALESSANDRONI, Rosina</creatorcontrib><creatorcontrib>SALVIOLI, Gian Paolo</creatorcontrib><creatorcontrib>FILOGRASSO, Nando</creatorcontrib><creatorcontrib>NOVELLI, Giuseppe</creatorcontrib><creatorcontrib>DALLAPICCOLA, Bruno</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DE LUCA, Alessandro</au><au>RIZZARDI, Mario</au><au>BUCCINO, Anna</au><au>ALESSANDRONI, Rosina</au><au>SALVIOLI, Gian Paolo</au><au>FILOGRASSO, Nando</au><au>NOVELLI, Giuseppe</au><au>DALLAPICCOLA, Bruno</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of dopamine D4 receptor (DRD4) exon III repeat polymorphism with temperament in 3-year-old infants</atitle><jtitle>Neurogenetics</jtitle><addtitle>Neurogenetics</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>4</volume><issue>4</issue><spage>207</spage><epage>212</epage><pages>207-212</pages><issn>1364-6745</issn><eissn>1364-6753</eissn><abstract>The long forms of the dopamine D4 receptor (DRD4) exon III repeat polymorphism (L-DRD4) have been linked in some studies to the adult personality trait of novelty seeking (NS), as well as to infant personality traits related to interest and activity. The current investigation extends the results of our previous longitudinal study on 1- to 5-month-old neonates assessed by the Early and Revised Infancy Temperament Questionnaire (EITQ/RITQ), in which we found a significant correlation between the DRD4 polymorphism and the adaptability trait at 1 month of age. In this study, we examined the relationship between children's behavior at 3 years of age, measured with the Toddler Temperament Scale (TTS), and DRD4 exon III repeat polymorphism. We found a significant association between the behavioral dimension of intensity of reaction and DRD4 genotypes. Current data failed to confirm the association with the adaptability trait. None of the extraversion and/or exploratory behavior measures was related to the L-DRD4 allele, as expected. In contrast, children with 4/7 genotypes showed worse response to new stimuli compared with 4/4 genotypes. This study corroborates only in part previous results on the link between the DRD4 gene and human temperament.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12687422</pmid><doi>10.1007/s10048-003-0146-z</doi><tpages>6</tpages></addata></record> |
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| ispartof | Neurogenetics, 2003-08, Vol.4 (4), p.207-212 |
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| subjects | Babies Behavioral psychophysiology Biological and medical sciences Child Behavior - physiology Child, Preschool Exons Exploratory Behavior - physiology Female Follow-Up Studies Fundamental and applied biological sciences. Psychology General aspects. Genetic counseling Genetics Humans Male Medical genetics Medical sciences Miscellaneous Neurotransmitters Personality traits Polymorphism, Genetic Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Receptors, Dopamine D2 - genetics Receptors, Dopamine D4 Temperament - physiology |
| title | Association of dopamine D4 receptor (DRD4) exon III repeat polymorphism with temperament in 3-year-old infants |
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