A Synthetic Approach to Nomofungin/Communesin B
A highly stereoselective intramolecular cycloaddition of an indole tethered to an aza-ortho-xylylene intermediate effects the rapid construction of a substantial portion of the ring system of the cytotoxic natural product communesin B. An analogous cycloaddition involving an ortho-quinone methide in...
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| Veröffentlicht in: | Organic letters 2003-09, Vol.5 (18), p.3169-3171 |
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| container_end_page | 3171 |
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| container_issue | 18 |
| container_start_page | 3169 |
| container_title | Organic letters |
| container_volume | 5 |
| creator | Crawley, Seth L Funk, Raymond L |
| description | A highly stereoselective intramolecular cycloaddition of an indole tethered to an aza-ortho-xylylene intermediate effects the rapid construction of a substantial portion of the ring system of the cytotoxic natural product communesin B. An analogous cycloaddition involving an ortho-quinone methide intermediate provides an adduct that clearly revealed that the structural assignment for nomofungin was in error. |
| doi_str_mv | 10.1021/ol034407v |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2003-09, Vol.5 (18), p.3169-3171 |
| issn | 1523-7060 1523-7052 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73599012 |
| source | MEDLINE; ACS Publications |
| subjects | Alkaloids - chemical synthesis Cyclization Epoxy Compounds - chemical synthesis Indolequinones - chemistry Molecular Structure |
| title | A Synthetic Approach to Nomofungin/Communesin B |
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