Hemoglobin heterogeneity under conditions of abnormal erythropoiesis

Hemoglobin heterogeneity under conditions of abnormal erythropoiesis

Experiments on rats showed that changes in the hemoglobin profile during hypoxia are determined by switching of erythropoiesis from the "basic" to "emergency" mode. The "basic" mode of erythropoiesis is typical of the mature organism under normal conditions. The "r...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2003-06, Vol.135 (6), p.563-565
Hauptverfasser: Sumin, M N, Rezaikin, A V, Yushkov, B G
Format: Artikel
Sprache:eng
Schlagworte:
Age Factors
Animals
Erythrocytes - chemistry
Erythrocytes - metabolism
Erythropoiesis - physiology
Hemoglobins - chemistry
Hemoglobins - metabolism
Humans
Hypoxia - metabolism
Male
Protein Isoforms - metabolism
Rats
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Zusammenfassung:Experiments on rats showed that changes in the hemoglobin profile during hypoxia are determined by switching of erythropoiesis from the "basic" to "emergency" mode. The "basic" mode of erythropoiesis is typical of the mature organism under normal conditions. The "reserve" or "emergency" mode is realized in fetuses, senile animals, and during hypoxia. This mode is characterized by production of large erythrocytes with high content of fetal hemoglobin.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1025477202093