Conjugation of phenol by rat lung
The metabolism of [U- 14C]phenol was studied in whole rat lung preparations and it was shown that [U- 14C]phenol was extensively metabolized. The fate of [U- 14C]phenol in isolated perfused rat lung preparations was the same when phenol was administered either intratracheally or systemically. [U- 14...
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| Veröffentlicht in: | Biochemical pharmacology 1981-06, Vol.30 (12), p.1551-1555 |
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| container_issue | 12 |
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| container_title | Biochemical pharmacology |
| container_volume | 30 |
| creator | Hogg, S.I. Curtis, C.G. Upshall, D.G. Powell, G.M. |
| description | The metabolism of [U-
14C]phenol was studied in whole rat lung preparations and it was shown that [U-
14C]phenol was extensively metabolized. The fate of [U-
14C]phenol in isolated perfused rat lung preparations was the same when phenol was administered either intratracheally or systemically. [U-
14C]Phenyl sulphate and [U-
14C]phenyl glucuronide were the major metabolites thus demonstrating the presence of appropriate sulphotransferase and glucuronyl transferase activity in the whole lung. [U-
14C]Phenol was not metabolized by rat pulmonary macrophages. |
| doi_str_mv | 10.1016/0006-2952(81)90380-4 |
| format | Article |
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14C]phenol was studied in whole rat lung preparations and it was shown that [U-
14C]phenol was extensively metabolized. The fate of [U-
14C]phenol in isolated perfused rat lung preparations was the same when phenol was administered either intratracheally or systemically. [U-
14C]Phenyl sulphate and [U-
14C]phenyl glucuronide were the major metabolites thus demonstrating the presence of appropriate sulphotransferase and glucuronyl transferase activity in the whole lung. [U-
14C]Phenol was not metabolized by rat pulmonary macrophages.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(81)90380-4</identifier><identifier>PMID: 7271846</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Animals ; Glucuronates - metabolism ; In Vitro Techniques ; Lung - metabolism ; Macrophages - metabolism ; Male ; Perfusion ; Phenol ; Phenols - metabolism ; Pulmonary Alveoli - metabolism ; Rats ; Sulfuric Acid Esters ; Sulfuric Acids - metabolism</subject><ispartof>Biochemical pharmacology, 1981-06, Vol.30 (12), p.1551-1555</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-80c96a38d9dc8e3242657eae51aef0499e4e0dd74b44e73d0547a01e4886bb2b3</citedby><cites>FETCH-LOGICAL-c357t-80c96a38d9dc8e3242657eae51aef0499e4e0dd74b44e73d0547a01e4886bb2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-2952(81)90380-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7271846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hogg, S.I.</creatorcontrib><creatorcontrib>Curtis, C.G.</creatorcontrib><creatorcontrib>Upshall, D.G.</creatorcontrib><creatorcontrib>Powell, G.M.</creatorcontrib><title>Conjugation of phenol by rat lung</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>The metabolism of [U-
14C]phenol was studied in whole rat lung preparations and it was shown that [U-
14C]phenol was extensively metabolized. The fate of [U-
14C]phenol in isolated perfused rat lung preparations was the same when phenol was administered either intratracheally or systemically. [U-
14C]Phenyl sulphate and [U-
14C]phenyl glucuronide were the major metabolites thus demonstrating the presence of appropriate sulphotransferase and glucuronyl transferase activity in the whole lung. [U-
14C]Phenol was not metabolized by rat pulmonary macrophages.</description><subject>Animals</subject><subject>Glucuronates - metabolism</subject><subject>In Vitro Techniques</subject><subject>Lung - metabolism</subject><subject>Macrophages - metabolism</subject><subject>Male</subject><subject>Perfusion</subject><subject>Phenol</subject><subject>Phenols - metabolism</subject><subject>Pulmonary Alveoli - metabolism</subject><subject>Rats</subject><subject>Sulfuric Acid Esters</subject><subject>Sulfuric Acids - metabolism</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UMtKxDAUDaKM4-gfKNSN6KKaNGkeG0EGXzDgRtchTW7HSKcZk1aYv7d1hlm6utx7HpdzEDon-JZgwu8wxjwvVFlcS3KjMJU4ZwdoSqSgw5nLQzTdU47RSUpf4yo5maCJKASRjE_R5Ty0X_3SdD60Waiz9Se0ocmqTRZNlzV9uzxFR7VpEpzt5gx9PD2-z1_yxdvz6_xhkVtaii6X2CpuqHTKWQm0YAUvBRgoiYEaM6WAAXZOsIoxENThkgmDCTApeVUVFZ2hq63vOobvHlKnVz5ZaBrTQuiTFrRUgmI-ENmWaGNIKUKt19GvTNxogvXYjB5z6jG2lkT_NaPZILvY-ffVCtxetKtiwO-3OAwhfzxEnayH1oLzEWynXfD_P_gFCzBwRQ</recordid><startdate>19810615</startdate><enddate>19810615</enddate><creator>Hogg, S.I.</creator><creator>Curtis, C.G.</creator><creator>Upshall, D.G.</creator><creator>Powell, G.M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19810615</creationdate><title>Conjugation of phenol by rat lung</title><author>Hogg, S.I. ; Curtis, C.G. ; Upshall, D.G. ; Powell, G.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-80c96a38d9dc8e3242657eae51aef0499e4e0dd74b44e73d0547a01e4886bb2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Glucuronates - metabolism</topic><topic>In Vitro Techniques</topic><topic>Lung - metabolism</topic><topic>Macrophages - metabolism</topic><topic>Male</topic><topic>Perfusion</topic><topic>Phenol</topic><topic>Phenols - metabolism</topic><topic>Pulmonary Alveoli - metabolism</topic><topic>Rats</topic><topic>Sulfuric Acid Esters</topic><topic>Sulfuric Acids - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hogg, S.I.</creatorcontrib><creatorcontrib>Curtis, C.G.</creatorcontrib><creatorcontrib>Upshall, D.G.</creatorcontrib><creatorcontrib>Powell, G.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hogg, S.I.</au><au>Curtis, C.G.</au><au>Upshall, D.G.</au><au>Powell, G.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conjugation of phenol by rat lung</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1981-06-15</date><risdate>1981</risdate><volume>30</volume><issue>12</issue><spage>1551</spage><epage>1555</epage><pages>1551-1555</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><abstract>The metabolism of [U-
14C]phenol was studied in whole rat lung preparations and it was shown that [U-
14C]phenol was extensively metabolized. The fate of [U-
14C]phenol in isolated perfused rat lung preparations was the same when phenol was administered either intratracheally or systemically. [U-
14C]Phenyl sulphate and [U-
14C]phenyl glucuronide were the major metabolites thus demonstrating the presence of appropriate sulphotransferase and glucuronyl transferase activity in the whole lung. [U-
14C]Phenol was not metabolized by rat pulmonary macrophages.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>7271846</pmid><doi>10.1016/0006-2952(81)90380-4</doi><tpages>5</tpages></addata></record> |
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| ispartof | Biochemical pharmacology, 1981-06, Vol.30 (12), p.1551-1555 |
| issn | 0006-2952 1873-2968 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Glucuronates - metabolism In Vitro Techniques Lung - metabolism Macrophages - metabolism Male Perfusion Phenol Phenols - metabolism Pulmonary Alveoli - metabolism Rats Sulfuric Acid Esters Sulfuric Acids - metabolism |
| title | Conjugation of phenol by rat lung |
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