Differentiation of parkinsonian syndromes according to differences in executive functions
Groups of patients with Parkinson's disease (PD), striatonigral degeneration-type multiple system atrophy (MSA) or progressive supranuclear palsy (PSP) with motor disability stages II and III according to Hoehn and Yahr, and a healthy control group were compared using neuropsychological tests o...
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| Veröffentlicht in: | Journal of Neural Transmission 2003-09, Vol.110 (9), p.983-995 |
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| creator | LANGE, K. W TUCHA, O VIEREGGE, P REINERS, K BECKER, G NAUMANN, M ALDERS, G. L PREIER, M CSOTI, I MERZ, B MARK, G HERTING, B FORNADI, F REICHMANN, H |
| description | Groups of patients with Parkinson's disease (PD), striatonigral degeneration-type multiple system atrophy (MSA) or progressive supranuclear palsy (PSP) with motor disability stages II and III according to Hoehn and Yahr, and a healthy control group were compared using neuropsychological tests of executive functions. The results indicate that all three patient groups were impaired in the tests of executive functions. In comparison with healthy subjects, the three patient groups showed impaired performance regarding verbal fluency, problem solving and verbal and figural working memory. Patients with PD differed significantly from healthy subjects in a test of verbal recency, while patients with MSA or PSP were unimpaired. The comparison of patient groups revealed no differences between PD and MSA patients. However, patients with PSP showed greater impairment in both phonemic and semantic fluency than patients with PD or MSA. Using discriminant function analysis, it was found that variables derived from four verbal fluency tasks (simple and alternate semantic and phonemic fluency) discriminated among the three patient groups at a level significantly exceeding chance. Over 90% of patients with PSP were correctly classified. Patients with PD and MSA were correctly classified in over 70% of cases. These results suggest that verbal fluency tasks may be sensitive measures in the differential diagnosis of PD, MSA and PSP. |
| doi_str_mv | 10.1007/s00702-003-0011-0 |
| format | Article |
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W ; TUCHA, O ; VIEREGGE, P ; REINERS, K ; BECKER, G ; NAUMANN, M ; ALDERS, G. L ; PREIER, M ; CSOTI, I ; MERZ, B ; MARK, G ; HERTING, B ; FORNADI, F ; REICHMANN, H</creator><creatorcontrib>LANGE, K. W ; TUCHA, O ; VIEREGGE, P ; REINERS, K ; BECKER, G ; NAUMANN, M ; ALDERS, G. L ; PREIER, M ; CSOTI, I ; MERZ, B ; MARK, G ; HERTING, B ; FORNADI, F ; REICHMANN, H</creatorcontrib><description>Groups of patients with Parkinson's disease (PD), striatonigral degeneration-type multiple system atrophy (MSA) or progressive supranuclear palsy (PSP) with motor disability stages II and III according to Hoehn and Yahr, and a healthy control group were compared using neuropsychological tests of executive functions. The results indicate that all three patient groups were impaired in the tests of executive functions. In comparison with healthy subjects, the three patient groups showed impaired performance regarding verbal fluency, problem solving and verbal and figural working memory. Patients with PD differed significantly from healthy subjects in a test of verbal recency, while patients with MSA or PSP were unimpaired. The comparison of patient groups revealed no differences between PD and MSA patients. However, patients with PSP showed greater impairment in both phonemic and semantic fluency than patients with PD or MSA. Using discriminant function analysis, it was found that variables derived from four verbal fluency tasks (simple and alternate semantic and phonemic fluency) discriminated among the three patient groups at a level significantly exceeding chance. Over 90% of patients with PSP were correctly classified. Patients with PD and MSA were correctly classified in over 70% of cases. These results suggest that verbal fluency tasks may be sensitive measures in the differential diagnosis of PD, MSA and PSP.</description><identifier>ISSN: 0300-9564</identifier><identifier>EISSN: 1435-1463</identifier><identifier>DOI: 10.1007/s00702-003-0011-0</identifier><identifier>PMID: 12938023</identifier><identifier>CODEN: JNTMAH</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Aged ; Biological and medical sciences ; Cognition - physiology ; Cognition Disorders - diagnosis ; Cognition Disorders - etiology ; Cognition Disorders - physiopathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Diagnosis, Differential ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Medical sciences ; Memory, Short-Term - physiology ; Middle Aged ; Multiple System Atrophy - complications ; Multiple System Atrophy - diagnosis ; Multiple System Atrophy - physiopathology ; Neurology ; Neuropsychological Tests ; Parkinson Disease - complications ; Parkinson Disease - diagnosis ; Parkinson Disease - physiopathology ; Parkinsonian Disorders - complications ; Parkinsonian Disorders - diagnosis ; Parkinsonian Disorders - physiopathology ; Speech Disorders - diagnosis ; Speech Disorders - etiology ; Speech Disorders - physiopathology ; Supranuclear Palsy, Progressive - complications ; Supranuclear Palsy, Progressive - diagnosis ; Supranuclear Palsy, Progressive - physiopathology ; Verbal Behavior - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Journal of Neural Transmission, 2003-09, Vol.110 (9), p.983-995</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-dabb39b44278a7ed7c5e7dcc7b77e4652d7de9c2c3820e27631c8997deb5214f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15086662$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12938023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LANGE, K. W</creatorcontrib><creatorcontrib>TUCHA, O</creatorcontrib><creatorcontrib>VIEREGGE, P</creatorcontrib><creatorcontrib>REINERS, K</creatorcontrib><creatorcontrib>BECKER, G</creatorcontrib><creatorcontrib>NAUMANN, M</creatorcontrib><creatorcontrib>ALDERS, G. L</creatorcontrib><creatorcontrib>PREIER, M</creatorcontrib><creatorcontrib>CSOTI, I</creatorcontrib><creatorcontrib>MERZ, B</creatorcontrib><creatorcontrib>MARK, G</creatorcontrib><creatorcontrib>HERTING, B</creatorcontrib><creatorcontrib>FORNADI, F</creatorcontrib><creatorcontrib>REICHMANN, H</creatorcontrib><title>Differentiation of parkinsonian syndromes according to differences in executive functions</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm (Vienna)</addtitle><description>Groups of patients with Parkinson's disease (PD), striatonigral degeneration-type multiple system atrophy (MSA) or progressive supranuclear palsy (PSP) with motor disability stages II and III according to Hoehn and Yahr, and a healthy control group were compared using neuropsychological tests of executive functions. The results indicate that all three patient groups were impaired in the tests of executive functions. In comparison with healthy subjects, the three patient groups showed impaired performance regarding verbal fluency, problem solving and verbal and figural working memory. Patients with PD differed significantly from healthy subjects in a test of verbal recency, while patients with MSA or PSP were unimpaired. The comparison of patient groups revealed no differences between PD and MSA patients. However, patients with PSP showed greater impairment in both phonemic and semantic fluency than patients with PD or MSA. Using discriminant function analysis, it was found that variables derived from four verbal fluency tasks (simple and alternate semantic and phonemic fluency) discriminated among the three patient groups at a level significantly exceeding chance. Over 90% of patients with PSP were correctly classified. Patients with PD and MSA were correctly classified in over 70% of cases. These results suggest that verbal fluency tasks may be sensitive measures in the differential diagnosis of PD, MSA and PSP.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cognition - physiology</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - physiopathology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory, Short-Term - physiology</subject><subject>Middle Aged</subject><subject>Multiple System Atrophy - complications</subject><subject>Multiple System Atrophy - diagnosis</subject><subject>Multiple System Atrophy - physiopathology</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinsonian Disorders - complications</subject><subject>Parkinsonian Disorders - diagnosis</subject><subject>Parkinsonian Disorders - physiopathology</subject><subject>Speech Disorders - diagnosis</subject><subject>Speech Disorders - etiology</subject><subject>Speech Disorders - physiopathology</subject><subject>Supranuclear Palsy, Progressive - complications</subject><subject>Supranuclear Palsy, Progressive - diagnosis</subject><subject>Supranuclear Palsy, Progressive - physiopathology</subject><subject>Verbal Behavior - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhkNR7PXqD-imDELFzejJ55lZlvoJBTd14Spkkoyk3ptckxlp_30z3IFCFxpIAsnzvpA8hJxReE8B8EOpC7AWgNdJaQsnZEMFly0Vij8jG-AAbS-VOCUvS7mFBcLuBTmlrOcdML4hPz-GcfTZxymYKaTYpLE5mPw7xJJiMLEp99HltPelMdam7EL81UypcWvM1osQG3_n7TyFv74Z52iXovKKPB_NrvjX674lPz5_urn62l5___Lt6vK6tVLA1DozDLwfhGDYGfQOrfTorMUB0QslmUPne8ss7xh4hopT2_V9PRwko2LkW_L22HvI6c_sy6T3oVi_25no01w0ctkrXseWvPsnSDuUnaQ9sv92UlTImMAKvnkC3qY5x_pezepXIyoJFaJHyOZUSvajPuSwN_leU9CLSH0UqatIvTjSS-Z8LZ6HvXePidVcBS5WwBRrdmM20YbyyEnolFKMPwDWrKXh</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>LANGE, K. 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L ; PREIER, M ; CSOTI, I ; MERZ, B ; MARK, G ; HERTING, B ; FORNADI, F ; REICHMANN, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-dabb39b44278a7ed7c5e7dcc7b77e4652d7de9c2c3820e27631c8997deb5214f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cognition - physiology</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - physiopathology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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W</au><au>TUCHA, O</au><au>VIEREGGE, P</au><au>REINERS, K</au><au>BECKER, G</au><au>NAUMANN, M</au><au>ALDERS, G. L</au><au>PREIER, M</au><au>CSOTI, I</au><au>MERZ, B</au><au>MARK, G</au><au>HERTING, B</au><au>FORNADI, F</au><au>REICHMANN, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differentiation of parkinsonian syndromes according to differences in executive functions</atitle><jtitle>Journal of Neural Transmission</jtitle><addtitle>J Neural Transm (Vienna)</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>110</volume><issue>9</issue><spage>983</spage><epage>995</epage><pages>983-995</pages><issn>0300-9564</issn><eissn>1435-1463</eissn><coden>JNTMAH</coden><abstract>Groups of patients with Parkinson's disease (PD), striatonigral degeneration-type multiple system atrophy (MSA) or progressive supranuclear palsy (PSP) with motor disability stages II and III according to Hoehn and Yahr, and a healthy control group were compared using neuropsychological tests of executive functions. The results indicate that all three patient groups were impaired in the tests of executive functions. In comparison with healthy subjects, the three patient groups showed impaired performance regarding verbal fluency, problem solving and verbal and figural working memory. Patients with PD differed significantly from healthy subjects in a test of verbal recency, while patients with MSA or PSP were unimpaired. The comparison of patient groups revealed no differences between PD and MSA patients. However, patients with PSP showed greater impairment in both phonemic and semantic fluency than patients with PD or MSA. Using discriminant function analysis, it was found that variables derived from four verbal fluency tasks (simple and alternate semantic and phonemic fluency) discriminated among the three patient groups at a level significantly exceeding chance. Over 90% of patients with PSP were correctly classified. Patients with PD and MSA were correctly classified in over 70% of cases. These results suggest that verbal fluency tasks may be sensitive measures in the differential diagnosis of PD, MSA and PSP.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>12938023</pmid><doi>10.1007/s00702-003-0011-0</doi><tpages>13</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Cognition - physiology Cognition Disorders - diagnosis Cognition Disorders - etiology Cognition Disorders - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diagnosis, Differential Female Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Memory, Short-Term - physiology Middle Aged Multiple System Atrophy - complications Multiple System Atrophy - diagnosis Multiple System Atrophy - physiopathology Neurology Neuropsychological Tests Parkinson Disease - complications Parkinson Disease - diagnosis Parkinson Disease - physiopathology Parkinsonian Disorders - complications Parkinsonian Disorders - diagnosis Parkinsonian Disorders - physiopathology Speech Disorders - diagnosis Speech Disorders - etiology Speech Disorders - physiopathology Supranuclear Palsy, Progressive - complications Supranuclear Palsy, Progressive - diagnosis Supranuclear Palsy, Progressive - physiopathology Verbal Behavior - physiology Vertebrates: nervous system and sense organs |
| title | Differentiation of parkinsonian syndromes according to differences in executive functions |
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