Human T Cell Surface Antigens Bearing a Structural Relationship to HLA Antigens
Three cell surface antigens that are structurally related to the human major histocompatibility antigens (called HLA antigens) have been characterized from the leukemic T cell line MOLT-4. One antigen is a glycoprotein of Mr49,000 recognized by two monoclonal antibodies, OKT6 and NA1/34, and is asso...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1981-06, Vol.78 (6), p.3858-3862 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Cotner, Tom Mashimo, Hiroshi Kung, Patrick C. Goldstein, Gideon Strominger, Jack L. |
| description | Three cell surface antigens that are structurally related to the human major histocompatibility antigens (called HLA antigens) have been characterized from the leukemic T cell line MOLT-4. One antigen is a glycoprotein of Mr49,000 recognized by two monoclonal antibodies, OKT6 and NA1/34, and is associated with a Mr12,000 subunit that crossreacts serologically with β2-microglobulin but can be distinguished from it by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. A second antigen, defined by the monoclonal antibody OKT10, is a Mr46,000 protein associated with a small subunit distinct from β2-microglobulin. The OKT10 antigen is not restricted to T cells and is found on all T and B lymphoblastoid cell lines tested. The third protein is a β2-microglobulin-associated glycoprotein of Mr43,000 that is serologically distinct from the OKT6 (NA1/34), OKT10, and HLA antigens. It is found on some, but not all, T cell lines but is absent from any other hematopoeitic cell lines tested. |
| doi_str_mv | 10.1073/pnas.78.6.3858 |
| format | Article |
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One antigen is a glycoprotein of Mr49,000 recognized by two monoclonal antibodies, OKT6 and NA1/34, and is associated with a Mr12,000 subunit that crossreacts serologically with β2-microglobulin but can be distinguished from it by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. A second antigen, defined by the monoclonal antibody OKT10, is a Mr46,000 protein associated with a small subunit distinct from β2-microglobulin. The OKT10 antigen is not restricted to T cells and is found on all T and B lymphoblastoid cell lines tested. The third protein is a β2-microglobulin-associated glycoprotein of Mr43,000 that is serologically distinct from the OKT6 (NA1/34), OKT10, and HLA antigens. It is found on some, but not all, T cell lines but is absent from any other hematopoeitic cell lines tested.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.78.6.3858</identifier><identifier>PMID: 6167992</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Antibodies ; Antigen-Antibody Complex ; Antigens ; Antigens, Surface ; beta 2-Microglobulin - immunology ; Cell lines ; cell surface ; Clone Cells - immunology ; Electrophoresis ; Epitopes ; Gels ; Glycoproteins - immunology ; histocompatibility antigens ; HLA A antigens ; HLA Antigens ; Humans ; Immunoprecipitation ; lymphocytes T ; Macromolecular Substances ; man ; Molecular Weight ; Monoclonal antibodies ; Protein Conformation ; T lymphocytes ; T-Lymphocytes - immunology</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1981-06, Vol.78 (6), p.3858-3862</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-3271d620d84682d23a5af63b126fb16714a056fa236b2dacb620b44900c026a83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/78/6.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/10937$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/10937$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6167992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cotner, Tom</creatorcontrib><creatorcontrib>Mashimo, Hiroshi</creatorcontrib><creatorcontrib>Kung, Patrick C.</creatorcontrib><creatorcontrib>Goldstein, Gideon</creatorcontrib><creatorcontrib>Strominger, Jack L.</creatorcontrib><title>Human T Cell Surface Antigens Bearing a Structural Relationship to HLA Antigens</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Three cell surface antigens that are structurally related to the human major histocompatibility antigens (called HLA antigens) have been characterized from the leukemic T cell line MOLT-4. One antigen is a glycoprotein of Mr49,000 recognized by two monoclonal antibodies, OKT6 and NA1/34, and is associated with a Mr12,000 subunit that crossreacts serologically with β2-microglobulin but can be distinguished from it by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. A second antigen, defined by the monoclonal antibody OKT10, is a Mr46,000 protein associated with a small subunit distinct from β2-microglobulin. The OKT10 antigen is not restricted to T cells and is found on all T and B lymphoblastoid cell lines tested. The third protein is a β2-microglobulin-associated glycoprotein of Mr43,000 that is serologically distinct from the OKT6 (NA1/34), OKT10, and HLA antigens. It is found on some, but not all, T cell lines but is absent from any other hematopoeitic cell lines tested.</description><subject>Antibodies</subject><subject>Antigen-Antibody Complex</subject><subject>Antigens</subject><subject>Antigens, Surface</subject><subject>beta 2-Microglobulin - immunology</subject><subject>Cell lines</subject><subject>cell surface</subject><subject>Clone Cells - immunology</subject><subject>Electrophoresis</subject><subject>Epitopes</subject><subject>Gels</subject><subject>Glycoproteins - immunology</subject><subject>histocompatibility antigens</subject><subject>HLA A antigens</subject><subject>HLA Antigens</subject><subject>Humans</subject><subject>Immunoprecipitation</subject><subject>lymphocytes T</subject><subject>Macromolecular Substances</subject><subject>man</subject><subject>Molecular Weight</subject><subject>Monoclonal antibodies</subject><subject>Protein Conformation</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb2P0zAchi0EOsrByoCE5Om2BH9_DAylAopU6STumK1fEqeXU-oU20Hw3-OqpSoLTB7e57Fe-0XoNSU1JZq_2wdItTa1qrmR5glaUGJppYQlT9GCEKYrI5h4jl6k9EgIsdKQK3SlqNLWsgW6Xc87CPger_w44rs59tB6vAx52PqQ8AcPcQhbDPgux7nNc4QRf_Uj5GEK6WHY4zzh9WZ5Nl6iZz2Myb86ndfo26eP96t1tbn9_GW13FStMDpXnGnaKUY6I5RhHeMgoVe8oUz1TelGBRCpemBcNayDtilsI8qjSEuYAsOv0fvjvfu52fmu9SGXam4fhx3EX26Cwf2dhOHBbacfjlOrNCv-zcmP0_fZp-x2Q2rLH0Dw05yc5tIKyf4PUsmslEQUsD6CbZxSir4_l6HEHaZyh6mcNk65w1RFeHv5hDN-2uYiP3h_0kv_5l-56-dxzP5nLuCbI_iY8hQvalmu-W8xr6-t</recordid><startdate>19810601</startdate><enddate>19810601</enddate><creator>Cotner, Tom</creator><creator>Mashimo, Hiroshi</creator><creator>Kung, Patrick C.</creator><creator>Goldstein, Gideon</creator><creator>Strominger, Jack L.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19810601</creationdate><title>Human T Cell Surface Antigens Bearing a Structural Relationship to HLA Antigens</title><author>Cotner, Tom ; Mashimo, Hiroshi ; Kung, Patrick C. ; Goldstein, Gideon ; Strominger, Jack L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-3271d620d84682d23a5af63b126fb16714a056fa236b2dacb620b44900c026a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Antibodies</topic><topic>Antigen-Antibody Complex</topic><topic>Antigens</topic><topic>Antigens, Surface</topic><topic>beta 2-Microglobulin - immunology</topic><topic>Cell lines</topic><topic>cell surface</topic><topic>Clone Cells - immunology</topic><topic>Electrophoresis</topic><topic>Epitopes</topic><topic>Gels</topic><topic>Glycoproteins - immunology</topic><topic>histocompatibility antigens</topic><topic>HLA A antigens</topic><topic>HLA Antigens</topic><topic>Humans</topic><topic>Immunoprecipitation</topic><topic>lymphocytes T</topic><topic>Macromolecular Substances</topic><topic>man</topic><topic>Molecular Weight</topic><topic>Monoclonal antibodies</topic><topic>Protein Conformation</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cotner, Tom</creatorcontrib><creatorcontrib>Mashimo, Hiroshi</creatorcontrib><creatorcontrib>Kung, Patrick C.</creatorcontrib><creatorcontrib>Goldstein, Gideon</creatorcontrib><creatorcontrib>Strominger, Jack L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cotner, Tom</au><au>Mashimo, Hiroshi</au><au>Kung, Patrick C.</au><au>Goldstein, Gideon</au><au>Strominger, Jack L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human T Cell Surface Antigens Bearing a Structural Relationship to HLA Antigens</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1981-06-01</date><risdate>1981</risdate><volume>78</volume><issue>6</issue><spage>3858</spage><epage>3862</epage><pages>3858-3862</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Three cell surface antigens that are structurally related to the human major histocompatibility antigens (called HLA antigens) have been characterized from the leukemic T cell line MOLT-4. One antigen is a glycoprotein of Mr49,000 recognized by two monoclonal antibodies, OKT6 and NA1/34, and is associated with a Mr12,000 subunit that crossreacts serologically with β2-microglobulin but can be distinguished from it by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. A second antigen, defined by the monoclonal antibody OKT10, is a Mr46,000 protein associated with a small subunit distinct from β2-microglobulin. The OKT10 antigen is not restricted to T cells and is found on all T and B lymphoblastoid cell lines tested. The third protein is a β2-microglobulin-associated glycoprotein of Mr43,000 that is serologically distinct from the OKT6 (NA1/34), OKT10, and HLA antigens. It is found on some, but not all, T cell lines but is absent from any other hematopoeitic cell lines tested.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>6167992</pmid><doi>10.1073/pnas.78.6.3858</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Antibodies Antigen-Antibody Complex Antigens Antigens, Surface beta 2-Microglobulin - immunology Cell lines cell surface Clone Cells - immunology Electrophoresis Epitopes Gels Glycoproteins - immunology histocompatibility antigens HLA A antigens HLA Antigens Humans Immunoprecipitation lymphocytes T Macromolecular Substances man Molecular Weight Monoclonal antibodies Protein Conformation T lymphocytes T-Lymphocytes - immunology |
| title | Human T Cell Surface Antigens Bearing a Structural Relationship to HLA Antigens |
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