Expression of angiogenic factors in neurofibromas
: We studied the expression of angiogenic factors (vascular endothelial growth factor, basic fibroblast growth factor, platelet‐derived growth factor and hepatocyte growth factor) in cutaneous neurofibroma samples from patients with neurofibromatosis‐1. Immunohistochemical staining and the reverse...
Gespeichert in:
| Veröffentlicht in: | Experimental dermatology 2003-08, Vol.12 (4), p.412-417 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 417 |
|---|---|
| container_issue | 4 |
| container_start_page | 412 |
| container_title | Experimental dermatology |
| container_volume | 12 |
| creator | Kawachi, Yasuhiro Xu, Xuezhu Ichikawa, Eiko Imakado, Sumihisa Otsuka, Fujio |
| description | : We studied the expression of angiogenic factors (vascular endothelial growth factor, basic fibroblast growth factor, platelet‐derived growth factor and hepatocyte growth factor) in cutaneous neurofibroma samples from patients with neurofibromatosis‐1. Immunohistochemical staining and the reverse transcribed polymerase chain reaction (RT‐PCR) method demonstrated that vascular endothelial and basic fibroblast growths factor are highly expressed in neurofibroma cells at both the protein and mRNA level. These data suggest that vascular endothelial and basic fibroblast growth factors may contribute to both the angiogenesis and hypervascularity of neurofibromas. |
| doi_str_mv | 10.1034/j.1600-0625.2003.00062.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73593584</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73593584</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5922-148b017152c895bfc40b0610d2571ff5f5504e605f4fcd8b00574a55ef7958f53</originalsourceid><addsrcrecordid>eNqNkcFu2zAMhoViQ5t2fYXBl-1mj5JF2wJ2GZIsHRB0PbRYboKsSIEyx8qkBE3efnITtNeeREDfTxIfCckoFBRK_m1d0Aogh4phwQDKAiDVxeGCjF4_PpARCKjyqga8ItcxrgFoXdZ4Sa4oEyUwUY8InR62wcTofJ95m6l-5fzK9E5nVumdDzFzfdabffDWtcFvVPxEPlrVRXN7fm_I08_p4_gun_-e_Rr_mOcaBWM55U2b5lFkuhHYWs2hhYrCkmFNrUWLCNxUgJZbvUwsYM0VorG1wMZieUO-nvpug_-3N3EnNy5q03WqN34fZV2iKLHhCWxOoA4-xmCs3Aa3UeEoKchBl1zLwYocrMhBl3zRJQ8p-vk8Y99uzPItePaTgC9nQEWtOhtUr11847jgjaAscd9P3LPrzPHdC8jpYpKKFM9PcRd35vAaV-GvrIaTyT_3MzlfzB7ni8mDnJX_AU1fkww</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73593584</pqid></control><display><type>article</type><title>Expression of angiogenic factors in neurofibromas</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Kawachi, Yasuhiro ; Xu, Xuezhu ; Ichikawa, Eiko ; Imakado, Sumihisa ; Otsuka, Fujio</creator><creatorcontrib>Kawachi, Yasuhiro ; Xu, Xuezhu ; Ichikawa, Eiko ; Imakado, Sumihisa ; Otsuka, Fujio</creatorcontrib><description>: We studied the expression of angiogenic factors (vascular endothelial growth factor, basic fibroblast growth factor, platelet‐derived growth factor and hepatocyte growth factor) in cutaneous neurofibroma samples from patients with neurofibromatosis‐1. Immunohistochemical staining and the reverse transcribed polymerase chain reaction (RT‐PCR) method demonstrated that vascular endothelial and basic fibroblast growths factor are highly expressed in neurofibroma cells at both the protein and mRNA level. These data suggest that vascular endothelial and basic fibroblast growth factors may contribute to both the angiogenesis and hypervascularity of neurofibromas.</description><identifier>ISSN: 0906-6705</identifier><identifier>EISSN: 1600-0625</identifier><identifier>DOI: 10.1034/j.1600-0625.2003.00062.x</identifier><identifier>PMID: 12930297</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>angiogenic factors ; Angiogenic Proteins - genetics ; Angiogenic Proteins - metabolism ; Base Sequence ; basic fibroblast growth factor ; Biological and medical sciences ; DNA, Complementary - genetics ; Fibroblast Growth Factor 2 - genetics ; Fibroblast Growth Factor 2 - metabolism ; Hepatocyte Growth Factor - genetics ; Hepatocyte Growth Factor - metabolism ; Humans ; Medical sciences ; neurofibroma ; Neurofibroma - genetics ; Neurofibroma - metabolism ; Neurofibromatosis 1 - genetics ; Neurofibromatosis 1 - metabolism ; Neurofibromatosis 2 - genetics ; Neurofibromatosis 2 - metabolism ; Neurology ; Proto-Oncogene Proteins c-sis - genetics ; Proto-Oncogene Proteins c-sis - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Skin Neoplasms - genetics ; Skin Neoplasms - metabolism ; Tumors of the nervous system. Phacomatoses ; vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - genetics ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>Experimental dermatology, 2003-08, Vol.12 (4), p.412-417</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5922-148b017152c895bfc40b0610d2571ff5f5504e605f4fcd8b00574a55ef7958f53</citedby><cites>FETCH-LOGICAL-c5922-148b017152c895bfc40b0610d2571ff5f5504e605f4fcd8b00574a55ef7958f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1034%2Fj.1600-0625.2003.00062.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1600-0625.2003.00062.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14948912$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12930297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawachi, Yasuhiro</creatorcontrib><creatorcontrib>Xu, Xuezhu</creatorcontrib><creatorcontrib>Ichikawa, Eiko</creatorcontrib><creatorcontrib>Imakado, Sumihisa</creatorcontrib><creatorcontrib>Otsuka, Fujio</creatorcontrib><title>Expression of angiogenic factors in neurofibromas</title><title>Experimental dermatology</title><addtitle>Exp Dermatol</addtitle><description>: We studied the expression of angiogenic factors (vascular endothelial growth factor, basic fibroblast growth factor, platelet‐derived growth factor and hepatocyte growth factor) in cutaneous neurofibroma samples from patients with neurofibromatosis‐1. Immunohistochemical staining and the reverse transcribed polymerase chain reaction (RT‐PCR) method demonstrated that vascular endothelial and basic fibroblast growths factor are highly expressed in neurofibroma cells at both the protein and mRNA level. These data suggest that vascular endothelial and basic fibroblast growth factors may contribute to both the angiogenesis and hypervascularity of neurofibromas.</description><subject>angiogenic factors</subject><subject>Angiogenic Proteins - genetics</subject><subject>Angiogenic Proteins - metabolism</subject><subject>Base Sequence</subject><subject>basic fibroblast growth factor</subject><subject>Biological and medical sciences</subject><subject>DNA, Complementary - genetics</subject><subject>Fibroblast Growth Factor 2 - genetics</subject><subject>Fibroblast Growth Factor 2 - metabolism</subject><subject>Hepatocyte Growth Factor - genetics</subject><subject>Hepatocyte Growth Factor - metabolism</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>neurofibroma</subject><subject>Neurofibroma - genetics</subject><subject>Neurofibroma - metabolism</subject><subject>Neurofibromatosis 1 - genetics</subject><subject>Neurofibromatosis 1 - metabolism</subject><subject>Neurofibromatosis 2 - genetics</subject><subject>Neurofibromatosis 2 - metabolism</subject><subject>Neurology</subject><subject>Proto-Oncogene Proteins c-sis - genetics</subject><subject>Proto-Oncogene Proteins c-sis - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Skin Neoplasms - genetics</subject><subject>Skin Neoplasms - metabolism</subject><subject>Tumors of the nervous system. Phacomatoses</subject><subject>vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>0906-6705</issn><issn>1600-0625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu2zAMhoViQ5t2fYXBl-1mj5JF2wJ2GZIsHRB0PbRYboKsSIEyx8qkBE3efnITtNeeREDfTxIfCckoFBRK_m1d0Aogh4phwQDKAiDVxeGCjF4_PpARCKjyqga8ItcxrgFoXdZ4Sa4oEyUwUY8InR62wcTofJ95m6l-5fzK9E5nVumdDzFzfdabffDWtcFvVPxEPlrVRXN7fm_I08_p4_gun_-e_Rr_mOcaBWM55U2b5lFkuhHYWs2hhYrCkmFNrUWLCNxUgJZbvUwsYM0VorG1wMZieUO-nvpug_-3N3EnNy5q03WqN34fZV2iKLHhCWxOoA4-xmCs3Aa3UeEoKchBl1zLwYocrMhBl3zRJQ8p-vk8Y99uzPItePaTgC9nQEWtOhtUr11847jgjaAscd9P3LPrzPHdC8jpYpKKFM9PcRd35vAaV-GvrIaTyT_3MzlfzB7ni8mDnJX_AU1fkww</recordid><startdate>200308</startdate><enddate>200308</enddate><creator>Kawachi, Yasuhiro</creator><creator>Xu, Xuezhu</creator><creator>Ichikawa, Eiko</creator><creator>Imakado, Sumihisa</creator><creator>Otsuka, Fujio</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200308</creationdate><title>Expression of angiogenic factors in neurofibromas</title><author>Kawachi, Yasuhiro ; Xu, Xuezhu ; Ichikawa, Eiko ; Imakado, Sumihisa ; Otsuka, Fujio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5922-148b017152c895bfc40b0610d2571ff5f5504e605f4fcd8b00574a55ef7958f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>angiogenic factors</topic><topic>Angiogenic Proteins - genetics</topic><topic>Angiogenic Proteins - metabolism</topic><topic>Base Sequence</topic><topic>basic fibroblast growth factor</topic><topic>Biological and medical sciences</topic><topic>DNA, Complementary - genetics</topic><topic>Fibroblast Growth Factor 2 - genetics</topic><topic>Fibroblast Growth Factor 2 - metabolism</topic><topic>Hepatocyte Growth Factor - genetics</topic><topic>Hepatocyte Growth Factor - metabolism</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>neurofibroma</topic><topic>Neurofibroma - genetics</topic><topic>Neurofibroma - metabolism</topic><topic>Neurofibromatosis 1 - genetics</topic><topic>Neurofibromatosis 1 - metabolism</topic><topic>Neurofibromatosis 2 - genetics</topic><topic>Neurofibromatosis 2 - metabolism</topic><topic>Neurology</topic><topic>Proto-Oncogene Proteins c-sis - genetics</topic><topic>Proto-Oncogene Proteins c-sis - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Skin Neoplasms - genetics</topic><topic>Skin Neoplasms - metabolism</topic><topic>Tumors of the nervous system. Phacomatoses</topic><topic>vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawachi, Yasuhiro</creatorcontrib><creatorcontrib>Xu, Xuezhu</creatorcontrib><creatorcontrib>Ichikawa, Eiko</creatorcontrib><creatorcontrib>Imakado, Sumihisa</creatorcontrib><creatorcontrib>Otsuka, Fujio</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawachi, Yasuhiro</au><au>Xu, Xuezhu</au><au>Ichikawa, Eiko</au><au>Imakado, Sumihisa</au><au>Otsuka, Fujio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of angiogenic factors in neurofibromas</atitle><jtitle>Experimental dermatology</jtitle><addtitle>Exp Dermatol</addtitle><date>2003-08</date><risdate>2003</risdate><volume>12</volume><issue>4</issue><spage>412</spage><epage>417</epage><pages>412-417</pages><issn>0906-6705</issn><eissn>1600-0625</eissn><abstract>: We studied the expression of angiogenic factors (vascular endothelial growth factor, basic fibroblast growth factor, platelet‐derived growth factor and hepatocyte growth factor) in cutaneous neurofibroma samples from patients with neurofibromatosis‐1. Immunohistochemical staining and the reverse transcribed polymerase chain reaction (RT‐PCR) method demonstrated that vascular endothelial and basic fibroblast growths factor are highly expressed in neurofibroma cells at both the protein and mRNA level. These data suggest that vascular endothelial and basic fibroblast growth factors may contribute to both the angiogenesis and hypervascularity of neurofibromas.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>12930297</pmid><doi>10.1034/j.1600-0625.2003.00062.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0906-6705 |
| ispartof | Experimental dermatology, 2003-08, Vol.12 (4), p.412-417 |
| issn | 0906-6705 1600-0625 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73593584 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | angiogenic factors Angiogenic Proteins - genetics Angiogenic Proteins - metabolism Base Sequence basic fibroblast growth factor Biological and medical sciences DNA, Complementary - genetics Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - metabolism Hepatocyte Growth Factor - genetics Hepatocyte Growth Factor - metabolism Humans Medical sciences neurofibroma Neurofibroma - genetics Neurofibroma - metabolism Neurofibromatosis 1 - genetics Neurofibromatosis 1 - metabolism Neurofibromatosis 2 - genetics Neurofibromatosis 2 - metabolism Neurology Proto-Oncogene Proteins c-sis - genetics Proto-Oncogene Proteins c-sis - metabolism Reverse Transcriptase Polymerase Chain Reaction Skin Neoplasms - genetics Skin Neoplasms - metabolism Tumors of the nervous system. Phacomatoses vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism |
| title | Expression of angiogenic factors in neurofibromas |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T19%3A36%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20angiogenic%20factors%20in%20neurofibromas&rft.jtitle=Experimental%20dermatology&rft.au=Kawachi,%20Yasuhiro&rft.date=2003-08&rft.volume=12&rft.issue=4&rft.spage=412&rft.epage=417&rft.pages=412-417&rft.issn=0906-6705&rft.eissn=1600-0625&rft_id=info:doi/10.1034/j.1600-0625.2003.00062.x&rft_dat=%3Cproquest_cross%3E73593584%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73593584&rft_id=info:pmid/12930297&rfr_iscdi=true |