Presynaptic proteins in the prefrontal cortex of patients with schizophrenia and rats with abnormal prefrontal development

Dysfunction of the prefrontal cortex in schizophrenia may be associated with abnormalities in synaptic structure and/or function and reflected in altered concentrations of proteins in presynaptic terminals and involved in synaptic plasticity (synaptobrevin/ vesicle-associated membrane protein (VAMP)...

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Veröffentlicht in:	Molecular psychiatry 2003-09, Vol.8 (9), p.797-810
Hauptverfasser:	Halim, N D, Weickert, C S, McClintock, B W, Hyde, T M, Weinberger, D R, Kleinman, J E, Lipska, B K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adult and adolescent clinical studies Aged Aged, 80 and over Animal models Animals Behavioral Sciences Biological and medical sciences Biological Psychology Biomarkers - analysis Brain research Carrier Proteins - analysis Case-Control Studies Disease Models, Animal Female GAP-43 protein GAP-43 Protein - analysis Hippocampus - chemistry Hippocampus - physiology Humans Immunoblotting Immunoreactivity Male Matched-Pair Analysis Medical sciences Medicine Medicine & Public Health Membrane proteins Membrane Proteins - analysis Mental disorders Middle Aged Nerve Net - chemistry Nerve Tissue Proteins - analysis Neurosciences original-research-article Pharmacotherapy Prefrontal cortex Prefrontal Cortex - abnormalities Prefrontal Cortex - chemistry Prefrontal Cortex - physiopathology Presynaptic plasticity Presynaptic Terminals - chemistry Proteins Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Qa-SNARE Proteins R-SNARE Proteins Rats Rats, Sprague-Dawley Rodents Schizophrenia Schizophrenia - physiopathology SNAP-25 protein SNARE Proteins Structure-function relationships Synapses Synaptic plasticity Synaptobrevin Synaptophysin Synaptophysin - analysis Synaptosomal-Associated Protein 25 Syntaxin Vesicular Transport Proteins
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