Antigen-specific densensitization in a rabbit model of acute hypersensitivity pneumonitis

Rabbits that had been prepared to develop acute alveolitis after aerosol challenge with simple protein antigens did not develop chronic alveolitis but rather gradually recovered despite continued challenge. Immunologic accompaniments of waning disease were compared in this model to those associated...

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Veröffentlicht in:Journal of allergy and clinical immunology 1981-09, Vol.68 (3), p.226-234
Hauptverfasser: Richerson, Hal B., Richards, David W., Swanson, Priscilla A., Butler, John E., Suelzer, Michael T.
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container_end_page 234
container_issue 3
container_start_page 226
container_title Journal of allergy and clinical immunology
container_volume 68
creator Richerson, Hal B.
Richards, David W.
Swanson, Priscilla A.
Butler, John E.
Suelzer, Michael T.
description Rabbits that had been prepared to develop acute alveolitis after aerosol challenge with simple protein antigens did not develop chronic alveolitis but rather gradually recovered despite continued challenge. Immunologic accompaniments of waning disease were compared in this model to those associated with intravenous injections of antigen causing “desensitization”. We also studied the effects of aerosol challenge prior to systemic immunization, antigen specificity, and the duration of desensitization by aerosolized and intravenous antigen. We found that repeated aerosol or intravenous challenges produced antigen-specific desensitization in this model, and the effect lasted several weeks. Prior exposure to aerosolized antigen was not protective. Neither aerosol nor intravenous desensitization maneuvers abrogated antigen-specific lymphocyte blastogenesis, although an early transient fall did occur. Humoral responses were boosted. These findings suggest that chronic alveolitis is prevented in this model by specific desensitization, without the induction of true tolerance or of nonspecific anergy. Such immunoregulation may result from development of antigen-specific blockade or blocking factors (e.g., lymphokines), antigen-antibody complexes, or suppressor cells affecting specific effector cells. Evaluation of these mechanisms may have implications for diagnosis and prognosis in human hypersensitivity pneumonitis.
doi_str_mv 10.1016/0091-6749(81)90188-3
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Immunologic accompaniments of waning disease were compared in this model to those associated with intravenous injections of antigen causing “desensitization”. We also studied the effects of aerosol challenge prior to systemic immunization, antigen specificity, and the duration of desensitization by aerosolized and intravenous antigen. We found that repeated aerosol or intravenous challenges produced antigen-specific desensitization in this model, and the effect lasted several weeks. Prior exposure to aerosolized antigen was not protective. Neither aerosol nor intravenous desensitization maneuvers abrogated antigen-specific lymphocyte blastogenesis, although an early transient fall did occur. Humoral responses were boosted. These findings suggest that chronic alveolitis is prevented in this model by specific desensitization, without the induction of true tolerance or of nonspecific anergy. 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Evaluation of these mechanisms may have implications for diagnosis and prognosis in human hypersensitivity pneumonitis.</description><subject>Acute Disease</subject><subject>Administration, Intranasal</subject><subject>Alveolitis, Extrinsic Allergic - immunology</subject><subject>Animals</subject><subject>Antigens - administration &amp; dosage</subject><subject>Cattle</subject><subject>Desensitization, Immunologic</subject><subject>Disease Models, Animal</subject><subject>Epitopes</subject><subject>Female</subject><subject>gamma-Globulins - immunology</subject><subject>Immunoglobulin A - biosynthesis</subject><subject>Injections, Intravenous</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Ovalbumin - immunology</subject><subject>Rabbits</subject><subject>Time Factors</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMouq7-A4WcRA_VfLRpchEW8QsEL3rwFNJ0opFtWpN2Yf31dt3iURgYXuadd5gHoRNKLimh4ooQRTNR5upc0gtFqJQZ30EzSlSZCcmKXTT7sxygw5Q-yai5VPtoX1BRCsJm6G0Rev8OIUsdWO-8xTWENJbv_bfpfRuwD9jgaKrK97hpa1ji1mFjhx7wx7qDOLlXvl_jLsDQtGGU6QjtObNMcDz1OXq9u325ecienu8fbxZPmeVU8gyMJEBMrYRgpjJWKSIKYLWjVtVKQeEsGFWwsrBEMGcskYzkNM-J48xVBZ-js21uF9uvAVKvG58sLJcmQDskXfJCMcbpaMy3RhvblCI43UXfmLjWlOgNUb3BpTe4tKT6l6jm49rplD9UDdR_SxPCcX69ncP45MpD1Ml6CBZqH8H2um79_wd-AG-qhtg</recordid><startdate>198109</startdate><enddate>198109</enddate><creator>Richerson, Hal B.</creator><creator>Richards, David W.</creator><creator>Swanson, Priscilla A.</creator><creator>Butler, John E.</creator><creator>Suelzer, Michael T.</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198109</creationdate><title>Antigen-specific densensitization in a rabbit model of acute hypersensitivity pneumonitis</title><author>Richerson, Hal B. ; Richards, David W. ; Swanson, Priscilla A. ; Butler, John E. ; Suelzer, Michael T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3183-ea80e0ad9662abac99065e2df1c9d99e5fcea95275c062fac082041440f32fb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Acute Disease</topic><topic>Administration, Intranasal</topic><topic>Alveolitis, Extrinsic Allergic - immunology</topic><topic>Animals</topic><topic>Antigens - administration &amp; dosage</topic><topic>Cattle</topic><topic>Desensitization, Immunologic</topic><topic>Disease Models, Animal</topic><topic>Epitopes</topic><topic>Female</topic><topic>gamma-Globulins - immunology</topic><topic>Immunoglobulin A - biosynthesis</topic><topic>Injections, Intravenous</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Ovalbumin - immunology</topic><topic>Rabbits</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Richerson, Hal B.</creatorcontrib><creatorcontrib>Richards, David W.</creatorcontrib><creatorcontrib>Swanson, Priscilla A.</creatorcontrib><creatorcontrib>Butler, John E.</creatorcontrib><creatorcontrib>Suelzer, Michael T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Richerson, Hal B.</au><au>Richards, David W.</au><au>Swanson, Priscilla A.</au><au>Butler, John E.</au><au>Suelzer, Michael T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antigen-specific densensitization in a rabbit model of acute hypersensitivity pneumonitis</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>1981-09</date><risdate>1981</risdate><volume>68</volume><issue>3</issue><spage>226</spage><epage>234</epage><pages>226-234</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><abstract>Rabbits that had been prepared to develop acute alveolitis after aerosol challenge with simple protein antigens did not develop chronic alveolitis but rather gradually recovered despite continued challenge. 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source MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals
subjects Acute Disease
Administration, Intranasal
Alveolitis, Extrinsic Allergic - immunology
Animals
Antigens - administration & dosage
Cattle
Desensitization, Immunologic
Disease Models, Animal
Epitopes
Female
gamma-Globulins - immunology
Immunoglobulin A - biosynthesis
Injections, Intravenous
Lymphocyte Activation
Male
Ovalbumin - immunology
Rabbits
Time Factors
title Antigen-specific densensitization in a rabbit model of acute hypersensitivity pneumonitis
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