Dacarbazine causes transcriptional up-regulation of interleukin 8 and vascular endothelial growth factor in melanoma cells: a possible escape mechanism from chemotherapy

The incidence of cutaneous malignant melanoma in the United States has increased more than any other cancer in recent years. Chemotherapy for metastatic melanoma is disappointing, there being anecdotal cases of complete remission. Dacarbazine (DTIC) is considered the gold standard for treatment, hav...

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Veröffentlicht in:	Molecular cancer therapeutics 2003-08, Vol.2 (8), p.753-763
Hauptverfasser:	Lev, Dina Chelouche, Ruiz, Maribelis, Mills, Lisa, McGary, Eric C, Price, Janet E, Bar-Eli, Menashe
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Dacarbazine - pharmacology Dose-Response Relationship, Drug Drug Resistance, Neoplasm Humans Interleukin-8 - genetics Interleukin-8 - metabolism Melanoma - metabolism Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism Transcription Factor AP-1 - metabolism Transcription, Genetic Transfection Up-Regulation Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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