Genetic constraints in the induction of the immune response to ehrlich ascites tumor in mice

A single injection of irradiated Ehrlich ascites tumor (EAT) cells induces immunity in normal mice but fails to do so in T-cell-deficient-thymectomized, lethally irradiated, bone marrow-reconstituted (TIR) mice. TIR mice injected with normal syngeneic T cells develop an immune response to EAT when i...

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Veröffentlicht in:	Cell. Immunol.; (United States) 1981-07, Vol.62 (1), p.93-100
Hauptverfasser:	Marǔsić, Matko, Perkins, Eugene H.
Format:	Artikel
Sprache:	eng
Schlagworte:	560152 - Radiation Effects on Animals- Animals ANIMAL CELLS ANIMALS Antibody Formation ASCITES TUMOR CELLS BIOLOGICAL MATERIALS BIOLOGICAL VARIABILITY BLOOD BLOOD CELLS BODY FLUIDS BONE MARROW CELLS Carcinoma, Ehrlich Tumor - immunology CHIMERAS CONNECTIVE TISSUE CELLS ELECTROMAGNETIC RADIATION Female GENETIC VARIABILITY H-2 Antigens - genetics IMMUNITY IMMUNOSUPPRESSION IONIZING RADIATIONS IRRADIATION LETHAL IRRADIATION LEUKOCYTES Lymphocyte Cooperation LYMPHOCYTES Male MAMMALS MATERIALS MICE Mice, Inbred C57BL - genetics Mice, Inbred CBA - genetics MOSAICISM Phenotype Radiation Chimera RADIATION CHIMERAS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOINDUCTION RODENTS SOMATIC CELLS T-Lymphocytes - immunology TUMOR CELLS VERTEBRATES X RADIATION
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