Genetic constraints in the induction of the immune response to ehrlich ascites tumor in mice
A single injection of irradiated Ehrlich ascites tumor (EAT) cells induces immunity in normal mice but fails to do so in T-cell-deficient-thymectomized, lethally irradiated, bone marrow-reconstituted (TIR) mice. TIR mice injected with normal syngeneic T cells develop an immune response to EAT when i...
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| Veröffentlicht in: | Cell. Immunol.; (United States) 1981-07, Vol.62 (1), p.93-100 |
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| creator | Marǔsić, Matko Perkins, Eugene H. |
| description | A single injection of irradiated Ehrlich ascites tumor (EAT) cells induces immunity in normal mice but fails to do so in T-cell-deficient-thymectomized, lethally irradiated, bone marrow-reconstituted (TIR) mice. TIR mice injected with normal syngeneic T cells develop an immune response to EAT when injected with irradiated EAT cells and reject a subsequent tumor cell challenge. In the present studies allogeneic T cells were unable to protect against EAT in TIR recipients even if harvested from donors tolerant to the recipient's transplantation antigens and injected into the TIR mice tolerant to the transplantation antigens of the injected T cells. Tolerance was produced by establishing long-term radiation chimeras of the P → F
1 type. Semiallogeneic T cells also failed to afford protection against EAT in TIR recipients. Whereas tolerance to other parental-strain transplantation antigens did not reverse the inability of parental T cells (cells from P → F
1 chimeric donors) to protect against EAT in F
1 TIR mice, it did enable F
1 T cells to afford protection in P → F
1 TIR mice. |
| doi_str_mv | 10.1016/0008-8749(81)90302-6 |
| format | Article |
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1 type. Semiallogeneic T cells also failed to afford protection against EAT in TIR recipients. Whereas tolerance to other parental-strain transplantation antigens did not reverse the inability of parental T cells (cells from P → F
1 chimeric donors) to protect against EAT in F
1 TIR mice, it did enable F
1 T cells to afford protection in P → F
1 TIR mice.</description><identifier>ISSN: 0008-8749</identifier><identifier>EISSN: 1090-2163</identifier><identifier>DOI: 10.1016/0008-8749(81)90302-6</identifier><identifier>PMID: 6973411</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>560152 - Radiation Effects on Animals- Animals ; ANIMAL CELLS ; ANIMALS ; Antibody Formation ; ASCITES TUMOR CELLS ; BIOLOGICAL MATERIALS ; BIOLOGICAL VARIABILITY ; BLOOD ; BLOOD CELLS ; BODY FLUIDS ; BONE MARROW CELLS ; Carcinoma, Ehrlich Tumor - immunology ; CHIMERAS ; CONNECTIVE TISSUE CELLS ; ELECTROMAGNETIC RADIATION ; Female ; GENETIC VARIABILITY ; H-2 Antigens - genetics ; IMMUNITY ; IMMUNOSUPPRESSION ; IONIZING RADIATIONS ; IRRADIATION ; LETHAL IRRADIATION ; LEUKOCYTES ; Lymphocyte Cooperation ; LYMPHOCYTES ; Male ; MAMMALS ; MATERIALS ; MICE ; Mice, Inbred C57BL - genetics ; Mice, Inbred CBA - genetics ; MOSAICISM ; Phenotype ; Radiation Chimera ; RADIATION CHIMERAS ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIATIONS ; RADIOINDUCTION ; RODENTS ; SOMATIC CELLS ; T-Lymphocytes - immunology ; TUMOR CELLS ; VERTEBRATES ; X RADIATION</subject><ispartof>Cell. Immunol.; (United States), 1981-07, Vol.62 (1), p.93-100</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c333t-6e9ae87d2076d09d5ce362bb9dc7de5939cbe00b60ad526c7d818227109459ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0008-8749(81)90302-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6973411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6229289$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Marǔsić, Matko</creatorcontrib><creatorcontrib>Perkins, Eugene H.</creatorcontrib><creatorcontrib>Oak Ridge National Lab., TN</creatorcontrib><title>Genetic constraints in the induction of the immune response to ehrlich ascites tumor in mice</title><title>Cell. Immunol.; (United States)</title><addtitle>Cell Immunol</addtitle><description>A single injection of irradiated Ehrlich ascites tumor (EAT) cells induces immunity in normal mice but fails to do so in T-cell-deficient-thymectomized, lethally irradiated, bone marrow-reconstituted (TIR) mice. TIR mice injected with normal syngeneic T cells develop an immune response to EAT when injected with irradiated EAT cells and reject a subsequent tumor cell challenge. In the present studies allogeneic T cells were unable to protect against EAT in TIR recipients even if harvested from donors tolerant to the recipient's transplantation antigens and injected into the TIR mice tolerant to the transplantation antigens of the injected T cells. Tolerance was produced by establishing long-term radiation chimeras of the P → F
1 type. Semiallogeneic T cells also failed to afford protection against EAT in TIR recipients. Whereas tolerance to other parental-strain transplantation antigens did not reverse the inability of parental T cells (cells from P → F
1 chimeric donors) to protect against EAT in F
1 TIR mice, it did enable F
1 T cells to afford protection in P → F
1 TIR mice.</description><subject>560152 - Radiation Effects on Animals- Animals</subject><subject>ANIMAL CELLS</subject><subject>ANIMALS</subject><subject>Antibody Formation</subject><subject>ASCITES TUMOR CELLS</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BIOLOGICAL VARIABILITY</subject><subject>BLOOD</subject><subject>BLOOD CELLS</subject><subject>BODY FLUIDS</subject><subject>BONE MARROW CELLS</subject><subject>Carcinoma, Ehrlich Tumor - immunology</subject><subject>CHIMERAS</subject><subject>CONNECTIVE TISSUE CELLS</subject><subject>ELECTROMAGNETIC RADIATION</subject><subject>Female</subject><subject>GENETIC VARIABILITY</subject><subject>H-2 Antigens - genetics</subject><subject>IMMUNITY</subject><subject>IMMUNOSUPPRESSION</subject><subject>IONIZING RADIATIONS</subject><subject>IRRADIATION</subject><subject>LETHAL IRRADIATION</subject><subject>LEUKOCYTES</subject><subject>Lymphocyte Cooperation</subject><subject>LYMPHOCYTES</subject><subject>Male</subject><subject>MAMMALS</subject><subject>MATERIALS</subject><subject>MICE</subject><subject>Mice, Inbred C57BL - genetics</subject><subject>Mice, Inbred CBA - genetics</subject><subject>MOSAICISM</subject><subject>Phenotype</subject><subject>Radiation Chimera</subject><subject>RADIATION CHIMERAS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIATIONS</subject><subject>RADIOINDUCTION</subject><subject>RODENTS</subject><subject>SOMATIC CELLS</subject><subject>T-Lymphocytes - immunology</subject><subject>TUMOR CELLS</subject><subject>VERTEBRATES</subject><subject>X RADIATION</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFr3DAQhUVpSTfb_IMGRA-hOTgdSbZsXQJhadJCIJf2FhC2NMsqrKWtJBfy7yPHS445Dcy8efPmI-QrgysGTP4AgK7q2lp979ilAgG8kh_IioGCijMpPpLVm-QzOU3pCYCxWsEJOZGqFTVjK_J4hx6zM9QEn3Lsnc-JOk_zDkuxk8kueBq2S2McJ480YjoUNdIcKO7i3pkd7ZNxGRPN0xjibDA6g1_Ip22_T3h2rGvy9_bnn82v6v7h7vfm5r4yQohcSVQ9dq3l0EoLyjYGheTDoKxpLTZKKDMgwCChtw2XpdmxjvO2fFo3qrdiTb4tviFlp1-TmF15yKPJWnKueKeK6GIRHWL4N2HKenTJ4H7fewxT0q1oFDQl0JrUi9DEkFLErT5EN_bxWTPQM3k9Y9UzVt0x_Upey7J2fvSfhhHt29IRdZlfL3MsJP47jHNQ9Aati3NOG9z7B14AcSmSYg</recordid><startdate>19810715</startdate><enddate>19810715</enddate><creator>Marǔsić, Matko</creator><creator>Perkins, Eugene H.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19810715</creationdate><title>Genetic constraints in the induction of the immune response to ehrlich ascites tumor in mice</title><author>Marǔsić, Matko ; Perkins, Eugene H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-6e9ae87d2076d09d5ce362bb9dc7de5939cbe00b60ad526c7d818227109459ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>560152 - Radiation Effects on Animals- Animals</topic><topic>ANIMAL CELLS</topic><topic>ANIMALS</topic><topic>Antibody Formation</topic><topic>ASCITES TUMOR CELLS</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BIOLOGICAL VARIABILITY</topic><topic>BLOOD</topic><topic>BLOOD CELLS</topic><topic>BODY FLUIDS</topic><topic>BONE MARROW CELLS</topic><topic>Carcinoma, Ehrlich Tumor - immunology</topic><topic>CHIMERAS</topic><topic>CONNECTIVE TISSUE CELLS</topic><topic>ELECTROMAGNETIC RADIATION</topic><topic>Female</topic><topic>GENETIC VARIABILITY</topic><topic>H-2 Antigens - genetics</topic><topic>IMMUNITY</topic><topic>IMMUNOSUPPRESSION</topic><topic>IONIZING RADIATIONS</topic><topic>IRRADIATION</topic><topic>LETHAL IRRADIATION</topic><topic>LEUKOCYTES</topic><topic>Lymphocyte Cooperation</topic><topic>LYMPHOCYTES</topic><topic>Male</topic><topic>MAMMALS</topic><topic>MATERIALS</topic><topic>MICE</topic><topic>Mice, Inbred C57BL - genetics</topic><topic>Mice, Inbred CBA - genetics</topic><topic>MOSAICISM</topic><topic>Phenotype</topic><topic>Radiation Chimera</topic><topic>RADIATION CHIMERAS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIATIONS</topic><topic>RADIOINDUCTION</topic><topic>RODENTS</topic><topic>SOMATIC CELLS</topic><topic>T-Lymphocytes - immunology</topic><topic>TUMOR CELLS</topic><topic>VERTEBRATES</topic><topic>X RADIATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marǔsić, Matko</creatorcontrib><creatorcontrib>Perkins, Eugene H.</creatorcontrib><creatorcontrib>Oak Ridge National Lab., TN</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Cell. Immunol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marǔsić, Matko</au><au>Perkins, Eugene H.</au><aucorp>Oak Ridge National Lab., TN</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic constraints in the induction of the immune response to ehrlich ascites tumor in mice</atitle><jtitle>Cell. Immunol.; (United States)</jtitle><addtitle>Cell Immunol</addtitle><date>1981-07-15</date><risdate>1981</risdate><volume>62</volume><issue>1</issue><spage>93</spage><epage>100</epage><pages>93-100</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><abstract>A single injection of irradiated Ehrlich ascites tumor (EAT) cells induces immunity in normal mice but fails to do so in T-cell-deficient-thymectomized, lethally irradiated, bone marrow-reconstituted (TIR) mice. TIR mice injected with normal syngeneic T cells develop an immune response to EAT when injected with irradiated EAT cells and reject a subsequent tumor cell challenge. In the present studies allogeneic T cells were unable to protect against EAT in TIR recipients even if harvested from donors tolerant to the recipient's transplantation antigens and injected into the TIR mice tolerant to the transplantation antigens of the injected T cells. Tolerance was produced by establishing long-term radiation chimeras of the P → F
1 type. Semiallogeneic T cells also failed to afford protection against EAT in TIR recipients. Whereas tolerance to other parental-strain transplantation antigens did not reverse the inability of parental T cells (cells from P → F
1 chimeric donors) to protect against EAT in F
1 TIR mice, it did enable F
1 T cells to afford protection in P → F
1 TIR mice.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>6973411</pmid><doi>10.1016/0008-8749(81)90302-6</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-8749 |
| ispartof | Cell. Immunol.; (United States), 1981-07, Vol.62 (1), p.93-100 |
| issn | 0008-8749 1090-2163 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73590533 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 560152 - Radiation Effects on Animals- Animals ANIMAL CELLS ANIMALS Antibody Formation ASCITES TUMOR CELLS BIOLOGICAL MATERIALS BIOLOGICAL VARIABILITY BLOOD BLOOD CELLS BODY FLUIDS BONE MARROW CELLS Carcinoma, Ehrlich Tumor - immunology CHIMERAS CONNECTIVE TISSUE CELLS ELECTROMAGNETIC RADIATION Female GENETIC VARIABILITY H-2 Antigens - genetics IMMUNITY IMMUNOSUPPRESSION IONIZING RADIATIONS IRRADIATION LETHAL IRRADIATION LEUKOCYTES Lymphocyte Cooperation LYMPHOCYTES Male MAMMALS MATERIALS MICE Mice, Inbred C57BL - genetics Mice, Inbred CBA - genetics MOSAICISM Phenotype Radiation Chimera RADIATION CHIMERAS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOINDUCTION RODENTS SOMATIC CELLS T-Lymphocytes - immunology TUMOR CELLS VERTEBRATES X RADIATION |
| title | Genetic constraints in the induction of the immune response to ehrlich ascites tumor in mice |
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