Comparison of conventional and real-time RT-PCR for the quantitation of jun protooncogene mRNA and analysis of junB mRNA expression in synovial membranes and isolated synovial fibroblasts from rheumatoid arthritis patients

AP-1 dependent genes, e.g., matrix-metallo-proteinases, are involved in the pathogenesis of rheumatoid arthritis (RA). Therefore, the transcription factor AP-1 and its subunits, proteins of the Jun and Fos proto-oncogene families, are interesting targets for analysis in RA. In this study, we analyze...

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Veröffentlicht in:	Zeitschrift für Rheumatologie 2003-08, Vol.62 (4), p.378-389
Hauptverfasser:	Huber, René, Kunisch, Elke, Glück, Brigitte, Egerer, Renate, Sickinger, Stefan, Kinne, Raimund W
Format:	Artikel
Sprache:	eng ; ger
Schlagworte:	Arthritis, Rheumatoid - genetics Fibroblasts - chemistry Gene Expression Regulation - genetics Genes, jun - genetics Genetic Testing - methods Humans Proto-Oncogene Proteins c-jun - genetics Reference Values Reproducibility of Results Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - isolation & purification Sensitivity and Specificity Synovial Membrane - chemistry
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