Pharmacological activity of phenazepam and flunitrazepam in ultralow doses

Experiments on male outbred albino rats showed that benzodiazepine tranquilizers phenazepam and flunitrazepam in ultralow doses (10(-9)-10(-15) mol/kg) produced an anxiolytic effect in the conflict situation test. This effect was not accompanied by myorelaxing and sedative side effects typical of st...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2003, Vol.135 Suppl 7, p.39-41
Hauptverfasser:	Molodavkin, G M, Voronina, T A, Chernyavskaya, L I, Burlakova, E B, Khorseva, N I, Seredenin, S B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology Behavior, Animal - drug effects Benzodiazepines - pharmacology Dose-Response Relationship, Drug Flunitrazepam - pharmacology Male Medazepam - pharmacology Rats Tranquilizing Agents - pharmacology
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Zusammenfassung:	Experiments on male outbred albino rats showed that benzodiazepine tranquilizers phenazepam and flunitrazepam in ultralow doses (10(-9)-10(-15) mol/kg) produced an anxiolytic effect in the conflict situation test. This effect was not accompanied by myorelaxing and sedative side effects typical of standard doses of tranquilizers.
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1024710225445